TY - JOUR
T1 - RhoGTPase signalling at epithelial tight junctions
T2 - Bridging the GAP between polarity and cancer
AU - Zihni, Ceniz
AU - Terry, Stephen James
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The establishment and maintenance of epithelial polarity must be correctly controlled for normal development and homeostasis. Tight junctions (TJ) in vertebrates define apical and basolateral membrane domains in polarized epithelia via bi-directional, complex signalling pathways between TJ themselves and the cytoskeleton they are associated with. RhoGTPases are central to these processes and evidence suggests that their regulation is coordinated by interactions between GEFs and GAPs with junctional, cytoplasmic adapter proteins. In this InFocus review we determine that the expression, localization or stability of a variety of these adaptor proteins is altered in various cancers, potentially representing an important mechanistic link between loss of polarity and cancer. We focus here, on two well characterized RhoGTPases Cdc42 and RhoA who's GEFs and GAPs are predominantly localized to TJ via cytoplasmic adaptor proteins.
AB - The establishment and maintenance of epithelial polarity must be correctly controlled for normal development and homeostasis. Tight junctions (TJ) in vertebrates define apical and basolateral membrane domains in polarized epithelia via bi-directional, complex signalling pathways between TJ themselves and the cytoskeleton they are associated with. RhoGTPases are central to these processes and evidence suggests that their regulation is coordinated by interactions between GEFs and GAPs with junctional, cytoplasmic adapter proteins. In this InFocus review we determine that the expression, localization or stability of a variety of these adaptor proteins is altered in various cancers, potentially representing an important mechanistic link between loss of polarity and cancer. We focus here, on two well characterized RhoGTPases Cdc42 and RhoA who's GEFs and GAPs are predominantly localized to TJ via cytoplasmic adaptor proteins.
KW - Cancer
KW - GAP
KW - GEF
KW - RhoGTPase
KW - Signalling
UR - http://www.scopus.com/inward/record.url?scp=84928527127&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2015.02.020
DO - 10.1016/j.biocel.2015.02.020
M3 - Article
AN - SCOPUS:84928527127
SN - 1357-2725
VL - 64
SP - 120
EP - 125
JO - The international journal of biochemistry & cell biology
JF - The international journal of biochemistry & cell biology
ER -
