Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges

Irene Cattaneo; Alexander D. Kalian; Matteo R. Di Nicola; Bruno Dujardin; Sara Levorato; Luc Mohimont; Alexis V. Nathanail; Edoardo Carnessechi; Maria Chiara Astuto; Jose V. Tarazona; George E.N. Kass; Antoine K.Djien Liem; Tobin Robinson; Paola Manini; Christer Hogstrand; Paul S. Price; Jean Lou C.M. Dorne

doi:10.3390/toxins15010040

Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges

Irene Cattaneo, Alexander D. Kalian, Matteo R. Di Nicola, Bruno Dujardin, Sara Levorato, Luc Mohimont, Alexis V. Nathanail, Edoardo Carnessechi, Maria Chiara Astuto, Jose V. Tarazona, George E.N. Kass, Antoine K.Djien Liem, Tobin Robinson, Paola Manini, Christer Hogstrand, Paul S. Price, Jean Lou C.M. Dorne^*

^*Corresponding author for this work

Institute of Pharmaceutical Science

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Human health and animal health risk assessment of combined exposure to multiple chemicals use the same steps as single-substance risk assessment, namely problem formulation, exposure assessment, hazard assessment and risk characterisation. The main unique feature of combined RA is the assessment of combined exposure, toxicity and risk. Recently, the Scientific Committee of the European Food Safety Authority (EFSA) published two relevant guidance documents. The first one “Harmonised methodologies for the human health, animal health and ecological risk assessment of combined exposure to multiple chemicals” provides principles and explores methodologies for all steps of risk assessment together with a reporting table. This guidance supports also the default assumption that dose addition is applied for combined toxicity of the chemicals unless evidence for response addition or interactions (antagonism or synergism) is available. The second guidance document provides an account of the scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods, i.e., exposure-driven and risk-based approaches. This manuscript describes such principles, provides a brief description of EFSA’s guidance documents, examples of applications in the human health and animal health area and concludes with a discussion on future challenges in this field.

Original language	English
Article number	40
Journal	Toxins
Volume	15
Issue number	1
DOIs	https://doi.org/10.3390/toxins15010040
Publication status	Published - Jan 2023

Keywords

animal health
assessment groups
combined exposure
component-based approach
future challenges
harmonised methodologies
human health
multiple chemicals
risk assessment

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10.3390/toxins15010040

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Cattaneo, I., Kalian, A. D., Di Nicola, M. R., Dujardin, B., Levorato, S., Mohimont, L., Nathanail, A. V., Carnessechi, E., Astuto, M. C., Tarazona, J. V., Kass, G. E. N., Liem, A. K. D., Robinson, T., Manini, P., Hogstrand, C., Price, P. S., & Dorne, J. L. C. M. (2023). Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges. Toxins, 15(1), Article 40. https://doi.org/10.3390/toxins15010040

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title = "Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges",

abstract = "Human health and animal health risk assessment of combined exposure to multiple chemicals use the same steps as single-substance risk assessment, namely problem formulation, exposure assessment, hazard assessment and risk characterisation. The main unique feature of combined RA is the assessment of combined exposure, toxicity and risk. Recently, the Scientific Committee of the European Food Safety Authority (EFSA) published two relevant guidance documents. The first one “Harmonised methodologies for the human health, animal health and ecological risk assessment of combined exposure to multiple chemicals” provides principles and explores methodologies for all steps of risk assessment together with a reporting table. This guidance supports also the default assumption that dose addition is applied for combined toxicity of the chemicals unless evidence for response addition or interactions (antagonism or synergism) is available. The second guidance document provides an account of the scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods, i.e., exposure-driven and risk-based approaches. This manuscript describes such principles, provides a brief description of EFSA{\textquoteright}s guidance documents, examples of applications in the human health and animal health area and concludes with a discussion on future challenges in this field.",

keywords = "animal health, assessment groups, combined exposure, component-based approach, future challenges, harmonised methodologies, human health, multiple chemicals, risk assessment",

author = "Irene Cattaneo and Kalian, {Alexander D.} and {Di Nicola}, {Matteo R.} and Bruno Dujardin and Sara Levorato and Luc Mohimont and Nathanail, {Alexis V.} and Edoardo Carnessechi and Astuto, {Maria Chiara} and Tarazona, {Jose V.} and Kass, {George E.N.} and Liem, {Antoine K.Djien} and Tobin Robinson and Paola Manini and Christer Hogstrand and Price, {Paul S.} and Dorne, {Jean Lou C.M.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jan,

doi = "10.3390/toxins15010040",

language = "English",

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Cattaneo, I, Kalian, AD, Di Nicola, MR, Dujardin, B, Levorato, S, Mohimont, L, Nathanail, AV, Carnessechi, E, Astuto, MC, Tarazona, JV, Kass, GEN, Liem, AKD, Robinson, T, Manini, P, Hogstrand, C, Price, PS & Dorne, JLCM 2023, 'Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges', Toxins, vol. 15, no. 1, 40. https://doi.org/10.3390/toxins15010040

TY - JOUR

T1 - Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority

T2 - Principles, Guidance Documents, Applications and Future Challenges

AU - Cattaneo, Irene

AU - Kalian, Alexander D.

AU - Di Nicola, Matteo R.

AU - Dujardin, Bruno

AU - Levorato, Sara

AU - Mohimont, Luc

AU - Nathanail, Alexis V.

AU - Carnessechi, Edoardo

AU - Astuto, Maria Chiara

AU - Tarazona, Jose V.

AU - Kass, George E.N.

AU - Liem, Antoine K.Djien

AU - Robinson, Tobin

AU - Manini, Paola

AU - Hogstrand, Christer

AU - Price, Paul S.

AU - Dorne, Jean Lou C.M.

PY - 2023/1

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N2 - Human health and animal health risk assessment of combined exposure to multiple chemicals use the same steps as single-substance risk assessment, namely problem formulation, exposure assessment, hazard assessment and risk characterisation. The main unique feature of combined RA is the assessment of combined exposure, toxicity and risk. Recently, the Scientific Committee of the European Food Safety Authority (EFSA) published two relevant guidance documents. The first one “Harmonised methodologies for the human health, animal health and ecological risk assessment of combined exposure to multiple chemicals” provides principles and explores methodologies for all steps of risk assessment together with a reporting table. This guidance supports also the default assumption that dose addition is applied for combined toxicity of the chemicals unless evidence for response addition or interactions (antagonism or synergism) is available. The second guidance document provides an account of the scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods, i.e., exposure-driven and risk-based approaches. This manuscript describes such principles, provides a brief description of EFSA’s guidance documents, examples of applications in the human health and animal health area and concludes with a discussion on future challenges in this field.

AB - Human health and animal health risk assessment of combined exposure to multiple chemicals use the same steps as single-substance risk assessment, namely problem formulation, exposure assessment, hazard assessment and risk characterisation. The main unique feature of combined RA is the assessment of combined exposure, toxicity and risk. Recently, the Scientific Committee of the European Food Safety Authority (EFSA) published two relevant guidance documents. The first one “Harmonised methodologies for the human health, animal health and ecological risk assessment of combined exposure to multiple chemicals” provides principles and explores methodologies for all steps of risk assessment together with a reporting table. This guidance supports also the default assumption that dose addition is applied for combined toxicity of the chemicals unless evidence for response addition or interactions (antagonism or synergism) is available. The second guidance document provides an account of the scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods, i.e., exposure-driven and risk-based approaches. This manuscript describes such principles, provides a brief description of EFSA’s guidance documents, examples of applications in the human health and animal health area and concludes with a discussion on future challenges in this field.

KW - animal health

KW - assessment groups

KW - combined exposure

KW - component-based approach

KW - future challenges

KW - harmonised methodologies

KW - human health

KW - multiple chemicals

KW - risk assessment

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U2 - 10.3390/toxins15010040

DO - 10.3390/toxins15010040

M3 - Review article

C2 - 36668860

AN - SCOPUS:85146779318

SN - 2072-6651

VL - 15

JO - Toxins

JF - Toxins

IS - 1

M1 - 40

ER -

Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges

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Keywords

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