Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study

Ismail M. Osmanov; Ekaterina Spiridonova; Polina Bobkova; Aysylu Gamirova; Anastasia Shikhaleva; Margarita Andreeva; Oleg Blyuss; Yasmin El-Taravi; Audrey DunnGalvin; Pasquale Comberiati; Diego G. Peroni; Christian Apfelbacher; Jon Genuneit; Lyudmila Mazankova; Alexandra Miroshina; Evgeniya Chistyakova; Elmira Samitova; Svetlana Borzakova; Elena Bondarenko; Anatoliy A. Korsunskiy; Irina Konova; Sarah Wulf Hanson; Gail Carson; Louise Sigfrid; Janet T. Scott; Matthew Greenhawt; Elizabeth A. Whittaker; Elena Garralda; Olivia, V Swann; Danilo Buonsenso; Dasha E. Nicholls; Frances Simpson; Christina Jones; Malcolm G. Semple; John O. Warner; Theo Vos; Piero Olliaro; Daniel Munblit

doi:10.1183/13993003.01341-2021

Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study

Ismail M. Osmanov, Ekaterina Spiridonova, Polina Bobkova, Aysylu Gamirova, Anastasia Shikhaleva, Margarita Andreeva, Oleg Blyuss, Yasmin El-Taravi, Audrey DunnGalvin, Pasquale Comberiati, Diego G. Peroni, Christian Apfelbacher, Jon Genuneit, Lyudmila Mazankova, Alexandra Miroshina, Evgeniya Chistyakova, Elmira Samitova, Svetlana Borzakova, Elena Bondarenko, Anatoliy A. KorsunskiyIrina Konova, Sarah Wulf Hanson, Gail Carson, Louise Sigfrid, Janet T. Scott, Matthew Greenhawt, Elizabeth A. Whittaker, Elena Garralda, Olivia, V Swann, Danilo Buonsenso, Dasha E. Nicholls, Frances Simpson, Christina Jones, Malcolm G. Semple, John O. Warner, Theo Vos, Piero Olliaro, Daniel Munblit

Care in Long Term Conditions

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Abstract

Background The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.

Methods This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.

Results 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3–15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (OR 2.74, 95% CI 1.37–5.75) and “12–18 years” (OR 2.68, 95% CI 1.41–5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04–2.67).

Conclusions A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

Original language	English
Journal	European Respiratory Journal
Volume	59
Issue number	2
DOIs	https://doi.org/10.1183/13993003.01341-2021
Publication status	Published - 1 Feb 2022

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Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort studyFinal published version, 926 KBLicence: CC BY

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Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., Blyuss, O., El-Taravi, Y., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Mazankova, L., Miroshina, A., Chistyakova, E., Samitova, E., Borzakova, S., Bondarenko, E., ... Munblit, D. (2022). Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. European Respiratory Journal, 59(2). https://doi.org/10.1183/13993003.01341-2021

@article{7cdfbaa23bf2498c800082ec530c64b3,

title = "Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study",

abstract = "Background The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.Methods This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.Results 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3–15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (OR 2.74, 95% CI 1.37–5.75) and “12–18 years” (OR 2.68, 95% CI 1.41–5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04–2.67).Conclusions A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.",

author = "Osmanov, {Ismail M.} and Ekaterina Spiridonova and Polina Bobkova and Aysylu Gamirova and Anastasia Shikhaleva and Margarita Andreeva and Oleg Blyuss and Yasmin El-Taravi and Audrey DunnGalvin and Pasquale Comberiati and Peroni, {Diego G.} and Christian Apfelbacher and Jon Genuneit and Lyudmila Mazankova and Alexandra Miroshina and Evgeniya Chistyakova and Elmira Samitova and Svetlana Borzakova and Elena Bondarenko and Korsunskiy, {Anatoliy A.} and Irina Konova and Hanson, {Sarah Wulf} and Gail Carson and Louise Sigfrid and Scott, {Janet T.} and Matthew Greenhawt and Whittaker, {Elizabeth A.} and Elena Garralda and Swann, {Olivia, V} and Danilo Buonsenso and Nicholls, {Dasha E.} and Frances Simpson and Christina Jones and Semple, {Malcolm G.} and Warner, {John O.} and Theo Vos and Piero Olliaro and Daniel Munblit",

year = "2022",

month = feb,

day = "1",

doi = "10.1183/13993003.01341-2021",

language = "English",

volume = "59",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "2",

}

Osmanov, IM, Spiridonova, E, Bobkova, P, Gamirova, A, Shikhaleva, A, Andreeva, M, Blyuss, O, El-Taravi, Y, DunnGalvin, A, Comberiati, P, Peroni, DG, Apfelbacher, C, Genuneit, J, Mazankova, L, Miroshina, A, Chistyakova, E, Samitova, E, Borzakova, S, Bondarenko, E, Korsunskiy, AA, Konova, I, Hanson, SW, Carson, G, Sigfrid, L, Scott, JT, Greenhawt, M, Whittaker, EA, Garralda, E, Swann, OV, Buonsenso, D, Nicholls, DE, Simpson, F, Jones, C, Semple, MG, Warner, JO, Vos, T, Olliaro, P & Munblit, D 2022, 'Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study', European Respiratory Journal, vol. 59, no. 2. https://doi.org/10.1183/13993003.01341-2021

TY - JOUR

T1 - Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study

AU - Osmanov, Ismail M.

AU - Spiridonova, Ekaterina

AU - Bobkova, Polina

AU - Gamirova, Aysylu

AU - Shikhaleva, Anastasia

AU - Andreeva, Margarita

AU - Blyuss, Oleg

AU - El-Taravi, Yasmin

AU - DunnGalvin, Audrey

AU - Comberiati, Pasquale

AU - Peroni, Diego G.

AU - Apfelbacher, Christian

AU - Genuneit, Jon

AU - Mazankova, Lyudmila

AU - Miroshina, Alexandra

AU - Chistyakova, Evgeniya

AU - Samitova, Elmira

AU - Borzakova, Svetlana

AU - Bondarenko, Elena

AU - Korsunskiy, Anatoliy A.

AU - Konova, Irina

AU - Hanson, Sarah Wulf

AU - Carson, Gail

AU - Sigfrid, Louise

AU - Scott, Janet T.

AU - Greenhawt, Matthew

AU - Whittaker, Elizabeth A.

AU - Garralda, Elena

AU - Swann, Olivia, V

AU - Buonsenso, Danilo

AU - Nicholls, Dasha E.

AU - Simpson, Frances

AU - Jones, Christina

AU - Semple, Malcolm G.

AU - Warner, John O.

AU - Vos, Theo

AU - Olliaro, Piero

AU - Munblit, Daniel

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Background The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.Methods This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.Results 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3–15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (OR 2.74, 95% CI 1.37–5.75) and “12–18 years” (OR 2.68, 95% CI 1.41–5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04–2.67).Conclusions A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

AB - Background The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.Methods This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.Results 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3–15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (OR 2.74, 95% CI 1.37–5.75) and “12–18 years” (OR 2.68, 95% CI 1.41–5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04–2.67).Conclusions A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

U2 - 10.1183/13993003.01341-2021

DO - 10.1183/13993003.01341-2021

M3 - Article

SN - 0903-1936

VL - 59

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 2

ER -

Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study

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