Risk factors for the development of bronchopulmonary dysplasia: the role of antenatal infection and inflammation

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    Abstract

    Bronchopulmonary dysplasia, chronic oxygen dependency, is a common adverse outcome of very premature birth. It has important implications for health resource utilization, since affected children require frequent readmissions to hospital in the first 2 years after birth and, even as adolescents, have lung function abnormalities and troublesome respiratory symptoms. The current population of very prematurely born infants may develop chronic oxygen dependency in the absence of severe, acute respiratory distress, so-called 'new' bronchopulmonary dysplasia. This appears to be the result of impaired antenatal lung growth; antenatal infection and inflammation make the premature infant's lungs more vulnerable to injury.
    Original languageEnglish
    Article numberN/A
    Pages (from-to)247-254
    Number of pages8
    JournalExpert review of respiratory medicine
    Volume1
    Issue number2
    DOIs
    Publication statusPublished - Oct 2007

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