Risk of relapse of multiple myeloma following kidney transplantation

Sapna Shah*, Maria Ibrahim, Michael Delaney, Steve Schey, Ceri Bygrave, Matthew Streetly, Reuben Benjamin

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Background. Autologous stem cell transplantation (ASCT) and novel therapies have improved the prognosis for patients with multiple myeloma (MM). For those who undergo ASCT while on dialysis, a similar survival compared with the overall MM population has been reported. Therefore, for patients achieving remission following ASCT, kidney transplantation is an attractive option, offering an improved quality of life and significant economic advantage. Method. This case series investigates the outcome of five patients who underwent an ASCT for MM with subsequent kidney transplantation between 2006 and 2012. Results. Four patients presented with end-stage renal disease (ESRD) and one progressed to ESRD shortly after diagnosis. Induction chemotherapy regimens with novel agents including thalidomide and bortezomib were utilized. Following attainment of very good partial remission or complete remission, high-dose melphalan ASCTs were performed after a median of 10months. Kidney transplantation (living donor n=3, deceased donor n=2) with tacrolimus-based immunosuppression regimens was completed at a median of 27months after ASCT. Patients 1 and 3 experienced relapse of myeloma at 6 and 16 months after kidney transplantation. Patients 2, 4 and 5 remain alive at 55months (median) after kidney transplantation with no evidence of relapse. Conclusion. Forty percent of our cohort experienced a relapse in MM within 2 years of kidney transplantation. Deathcensored graft survival and patient survival were 80% at 4 years. Our study adds to the growing literature supporting kidney transplantation following successful ASCT for MM and is useful when counselling patients regarding renal and haematological outcomes.

    Original languageEnglish
    Article numbersfy137
    Pages (from-to)216-223
    Number of pages8
    JournalClinical Kidney Journal
    Volume12
    Issue number2
    Early online date25 Jan 2019
    DOIs
    Publication statusPublished - Apr 2019

    Keywords

    • Autologous stem cell transplantation
    • Kidney transplantation
    • Multiple myeloma
    • Outcome

    Fingerprint

    Dive into the research topics of 'Risk of relapse of multiple myeloma following kidney transplantation'. Together they form a unique fingerprint.

    Cite this