Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Dieter Schrenk; Margherita Bignami; Laurent Bodin; James Kevin Chipman; Jesús del Mazo; Bettina Grasl-Kraupp; Christer Hogstrand; Laurentius (Ron) Hoogenboom; Jean-Charles Leblanc; Carlo Stefano Nebbia; Elsa Nielsen; Evangelia Ntzani; Salomon Sand; Tanja Schwerdtle; Christiane Vleminckx; Heather Wallace; Jürgen Gropp; Gunther Antonissen; Guido Rychen; José Ángel Gómez Ruiz; Matteo Lorenzo Innocenti; Elena Rovesti; Annette Petersen

doi:10.2903/j.efsa.2023.8375

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean-Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Jürgen Gropp, Gunther Antonissen, Guido Rychen, José Ángel Gómez RuizMatteo Lorenzo Innocenti, Elena Rovesti, Annette Petersen

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10 Citations (Scopus)

Abstract

Abstract In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01?mg OTA/kg feed, for chickens for fattening and hens 0.03?mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.

Original language	English
Pages (from-to)	e08375
Journal	EFSA Journal
Volume	21
Issue number	11
DOIs	https://doi.org/10.2903/j.efsa.2023.8375
Publication status	Published - 2023

Keywords

ochratoxin A
OTA
feed
exposure
toxicity
animal health risk assessment

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10.2903/j.efsa.2023.8375

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Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L., Leblanc, J.-C., Nebbia, C. S., Nielsen, E., Ntzani, E., Sand, S., Schwerdtle, T., Vleminckx, C., Wallace, H., Gropp, J., Antonissen, G., Rychen, G., ... Petersen, A. (2023). Risks for animal health related to the presence of ochratoxin A (OTA) in feed. EFSA Journal, 21(11), e08375. https://doi.org/10.2903/j.efsa.2023.8375

@article{b5831762e9ed4d7aac9a9f460d08afb5,

title = "Risks for animal health related to the presence of ochratoxin A (OTA) in feed",

abstract = "Abstract In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01?mg OTA/kg feed, for chickens for fattening and hens 0.03?mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.",

keywords = "ochratoxin A, OTA, feed, exposure, toxicity, animal health risk assessment",

author = "Dieter Schrenk and Margherita Bignami and Laurent Bodin and Chipman, {James Kevin} and {del Mazo}, Jes{\'u}s and Bettina Grasl-Kraupp and Christer Hogstrand and Hoogenboom, {Laurentius (Ron)} and Jean-Charles Leblanc and Nebbia, {Carlo Stefano} and Elsa Nielsen and Evangelia Ntzani and Salomon Sand and Tanja Schwerdtle and Christiane Vleminckx and Heather Wallace and J{\"u}rgen Gropp and Gunther Antonissen and Guido Rychen and {G{\'o}mez Ruiz}, {Jos{\'e} {\'A}ngel} and Innocenti, {Matteo Lorenzo} and Elena Rovesti and Annette Petersen",

year = "2023",

doi = "10.2903/j.efsa.2023.8375",

language = "English",

volume = "21",

pages = "e08375",

journal = "EFSA Journal",

issn = "1831-4732",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "11",

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Schrenk, D, Bignami, M, Bodin, L, Chipman, JK, del Mazo, J, Grasl-Kraupp, B, Hogstrand, C, Hoogenboom, L, Leblanc, J-C, Nebbia, CS, Nielsen, E, Ntzani, E, Sand, S, Schwerdtle, T, Vleminckx, C, Wallace, H, Gropp, J, Antonissen, G, Rychen, G, Gómez Ruiz, JÁ, Innocenti, ML, Rovesti, E & Petersen, A 2023, 'Risks for animal health related to the presence of ochratoxin A (OTA) in feed', EFSA Journal, vol. 21, no. 11, pp. e08375. https://doi.org/10.2903/j.efsa.2023.8375

TY - JOUR

T1 - Risks for animal health related to the presence of ochratoxin A (OTA) in feed

AU - Schrenk, Dieter

AU - Bignami, Margherita

AU - Bodin, Laurent

AU - Chipman, James Kevin

AU - del Mazo, Jesús

AU - Grasl-Kraupp, Bettina

AU - Hogstrand, Christer

AU - Hoogenboom, Laurentius (Ron)

AU - Leblanc, Jean-Charles

AU - Nebbia, Carlo Stefano

AU - Nielsen, Elsa

AU - Ntzani, Evangelia

AU - Sand, Salomon

AU - Schwerdtle, Tanja

AU - Vleminckx, Christiane

AU - Wallace, Heather

AU - Gropp, Jürgen

AU - Antonissen, Gunther

AU - Rychen, Guido

AU - Gómez Ruiz, José Ángel

AU - Innocenti, Matteo Lorenzo

AU - Rovesti, Elena

AU - Petersen, Annette

PY - 2023

Y1 - 2023

N2 - Abstract In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01?mg OTA/kg feed, for chickens for fattening and hens 0.03?mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.

AB - Abstract In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01?mg OTA/kg feed, for chickens for fattening and hens 0.03?mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.

KW - ochratoxin A

KW - OTA

KW - feed

KW - exposure

KW - toxicity

KW - animal health risk assessment

U2 - 10.2903/j.efsa.2023.8375

DO - 10.2903/j.efsa.2023.8375

M3 - Article

SN - 1831-4732

VL - 21

SP - e08375

JO - EFSA Journal

JF - EFSA Journal

IS - 11

ER -

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Abstract

Keywords

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