@article{ada754fbc1904d338523e61714ccd719,
title = "RNA interference therapeutics for cardiac regeneration",
abstract = "There is an impelling need to develop new therapeutics for myocardial infarction and heart failure. A novel and exciting therapeutic possibility is to achieve cardiac regeneration through the stimulation of the endogenous capacity of cardiomyocytes to proliferate. Proof-of-concept evidence of microRNA-induced cardiac regeneration is available in both small and large animals using viral vectors. However, a clinically more applicable strategy is the development of lipid-mediated nanotechnologies for the administration of RNA therapeutics as synthetic molecules. The recent success of the Stable Nucleic Acid Lipid Particle (SNALP) platform for the generation of nanosized, efficient and non-inflammatory lipid nanoparticles paves the way to the development of injectable nanoformulations of microRNAs through cardiac catheterisation.",
author = "Josef Huntington and Manendra Pachauri and Hashim Ali and Mauro Giacca",
note = "Funding Information: This work was supported by the British Heart Foundation (BHF) Programme Grant RG/19/11/34633 ; the European Research Council (ERC) Advanced Grant 787971 {\textquoteleft}CuRE{\textquoteright}; the King{\textquoteright}s College London BHF Centre of Research Excellence grant RE/18/2/34213 ; by grants 825670 {\textquoteleft}CardioReGenix{\textquoteright} and 874764 {\textquoteleft}REANIMA{\textquoteright} from the European Commission Horizon 2020 programme, along with the continuous support of Fondazione CRTrieste, Trieste, Italy. Funding Information: This work was supported by the British Heart Foundation (BHF) Programme Grant RG/19/11/34633; the European Research Council (ERC) Advanced Grant 787971 ?CuRE?; the King's College London BHF Centre of Research Excellence grant RE/18/2/34213; by grants 825670 ?CardioReGenix? and 874764 ?REANIMA? from the European Commission Horizon 2020 programme, along with the continuous support of Fondazione CRTrieste, Trieste, Italy. Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = oct,
doi = "10.1016/j.gde.2021.05.007",
language = "English",
volume = "70",
pages = "48--53",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",
}
