RNA modifications shed new light on DNA's older brother

TY - JOUR

T1 - RNA modifications shed new light on DNA's older brother

AU - Murison, Keir H.

AU - Holland, Michelle L.

N1 - Publisher Copyright: © 2017 Biochemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2017

Y1 - 2017

N2 - Epigenetics, which literally means 'on top of genetics', is a term that describes factors that influence gene expression and are mitotically heritable, but potentially reversible. Recently, N6- methyladenosine (m6A) has been identified as a reversible RNA modification that is widespread in mRNA. This is just one of hundreds of modifications to RNA. These exciting findings led to the birth of 'epitranscriptomics'- the study of reversible RNA modifications. We discuss specific examples of how epigenetic and epitranscriptomic, mechanisms interact to collectively modify genomic output and highlight how these two intertwined forms of gene regulation contribute to homeostasis and stress adaptation.

AB - Epigenetics, which literally means 'on top of genetics', is a term that describes factors that influence gene expression and are mitotically heritable, but potentially reversible. Recently, N6- methyladenosine (m6A) has been identified as a reversible RNA modification that is widespread in mRNA. This is just one of hundreds of modifications to RNA. These exciting findings led to the birth of 'epitranscriptomics'- the study of reversible RNA modifications. We discuss specific examples of how epigenetic and epitranscriptomic, mechanisms interact to collectively modify genomic output and highlight how these two intertwined forms of gene regulation contribute to homeostasis and stress adaptation.

UR - http://www.scopus.com/inward/record.url?scp=85030547079&partnerID=8YFLogxK

U2 - 10.1042/bio03905016

DO - 10.1042/bio03905016

M3 - Article

AN - SCOPUS:85030547079

SN - 0954-982X

VL - 39

SP - 16

EP - 19

JO - Biochemist

JF - Biochemist

IS - 5

ER -