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Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

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Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. / Escot, Sophie; Willnow, David; Naumann, Heike Anita; DiFrancescantonio, Silvia; Spagnoli, Francesca Maria.

In: Nature Communications, Vol. 9, 5082, 2018.

Research output: Contribution to journalArticle

Harvard

Escot, S, Willnow, D, Naumann, HA, DiFrancescantonio, S & Spagnoli, FM 2018, 'Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors', Nature Communications, vol. 9, 5082. https://doi.org/10.1038/s41467-018-07474-6

APA

Escot, S., Willnow, D., Naumann, H. A., DiFrancescantonio, S., & Spagnoli, F. M. (2018). Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nature Communications, 9, [5082]. https://doi.org/10.1038/s41467-018-07474-6

Vancouver

Escot S, Willnow D, Naumann HA, DiFrancescantonio S, Spagnoli FM. Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nature Communications. 2018;9. 5082. https://doi.org/10.1038/s41467-018-07474-6

Author

Escot, Sophie ; Willnow, David ; Naumann, Heike Anita ; DiFrancescantonio, Silvia ; Spagnoli, Francesca Maria. / Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. In: Nature Communications. 2018 ; Vol. 9.

Bibtex Download

@article{4912a669aa244aaa8aa1f1ac69c0e8a8,
title = "Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors",
abstract = "A complex interplay of intrinsic factors and extrinsic signalling pathways controls both cell lineage commitment and maintenance of cell identity. Loss of defined cellular states is the cause of many different cancers, including pancreatic cancer. Recent findings suggest a clinical role for the conserved SLIT/ROBO signalling pathway in pancreatic cancer. However, whilst this pathway has been extensively studied in many processes, a role for Slit and Robo genes in pancreas cell identity and plasticity has not been established yet. Here, we identify Slit/Robo signalling as a key regulator of pancreatic progenitor identity. We find that Robo1 and Robo2 are required for preserving pancreatic cell identity shortly after fate induction and, subsequently, for expansion of the pancreatic progenitor pool in the mouse. Furthermore, we show that Robo receptors control the expression of Tead transcription factors as well as its downstream transcriptional activity. Our work identifies an interplay between Slit/Robo pathway and Tead intrinsic regulators, functioning as gatekeeper of pancreatic cell identity.",
author = "Sophie Escot and David Willnow and Naumann, {Heike Anita} and Silvia DiFrancescantonio and Spagnoli, {Francesca Maria}",
year = "2018",
doi = "10.1038/s41467-018-07474-6",
language = "English",
volume = "9",
journal = "Nat Commun",
issn = "2041-1723",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

AU - Escot, Sophie

AU - Willnow, David

AU - Naumann, Heike Anita

AU - DiFrancescantonio, Silvia

AU - Spagnoli, Francesca Maria

PY - 2018

Y1 - 2018

N2 - A complex interplay of intrinsic factors and extrinsic signalling pathways controls both cell lineage commitment and maintenance of cell identity. Loss of defined cellular states is the cause of many different cancers, including pancreatic cancer. Recent findings suggest a clinical role for the conserved SLIT/ROBO signalling pathway in pancreatic cancer. However, whilst this pathway has been extensively studied in many processes, a role for Slit and Robo genes in pancreas cell identity and plasticity has not been established yet. Here, we identify Slit/Robo signalling as a key regulator of pancreatic progenitor identity. We find that Robo1 and Robo2 are required for preserving pancreatic cell identity shortly after fate induction and, subsequently, for expansion of the pancreatic progenitor pool in the mouse. Furthermore, we show that Robo receptors control the expression of Tead transcription factors as well as its downstream transcriptional activity. Our work identifies an interplay between Slit/Robo pathway and Tead intrinsic regulators, functioning as gatekeeper of pancreatic cell identity.

AB - A complex interplay of intrinsic factors and extrinsic signalling pathways controls both cell lineage commitment and maintenance of cell identity. Loss of defined cellular states is the cause of many different cancers, including pancreatic cancer. Recent findings suggest a clinical role for the conserved SLIT/ROBO signalling pathway in pancreatic cancer. However, whilst this pathway has been extensively studied in many processes, a role for Slit and Robo genes in pancreas cell identity and plasticity has not been established yet. Here, we identify Slit/Robo signalling as a key regulator of pancreatic progenitor identity. We find that Robo1 and Robo2 are required for preserving pancreatic cell identity shortly after fate induction and, subsequently, for expansion of the pancreatic progenitor pool in the mouse. Furthermore, we show that Robo receptors control the expression of Tead transcription factors as well as its downstream transcriptional activity. Our work identifies an interplay between Slit/Robo pathway and Tead intrinsic regulators, functioning as gatekeeper of pancreatic cell identity.

U2 - 10.1038/s41467-018-07474-6

DO - 10.1038/s41467-018-07474-6

M3 - Article

VL - 9

JO - Nat Commun

JF - Nat Commun

SN - 2041-1723

M1 - 5082

ER -

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