Robust registration between cardiac MRI images and atlas for segmentation propagation - art. no. 691408

X. Zhuang, D. J. Hawkes, William Crum, R. Boubertakh, S. Uribe, D. Atkinson, P. Batchelor, T. Schaeffter, R. Razavi, D. L. G. Hill

Research output: Chapter in Book/Report/Conference proceedingConference paper


We propose a new framework to propagate the labels in a heart atlas to the cardiac MRI images for ventricle segmentations based on image registrations. The method employs the anatomical information from the atlas as priors to constrain the initialisation between the atlas and die MRI images using region based registrations. After the initialisation which minimises the possibility of local misalignments, a fluid registration is applied to fine-tune the labelling in the atlas to the detail in the MRI images. The heart shape from the atlas does not have to be representative of that of the segmented MRI images in terms of morphological variations of the heart in this framework. In the experiments, a cadaver heart atlas and a normal heart atlas were used to register to in-vivo data for ventricle segmentation propagations. The results have shown that the segmentations based on the proposed method are visually acceptable, accurate (surface distance against manual segmentations is 1.0 +/- 1.0 mm in healthy volunteer data, and 1.6 +/- 1.8 mm in patient data), and reproducible (0.7 +/- 1.0 mm) for in-vivo cardiac MRI images. The experiments also show that the new initialisation method can correct the local misalignments and help to avoid producing unrealistic deformations in the nonrigid registrations with 21% quantitative improvement of the segmentation accuracy.

Original languageEnglish
Title of host publicationMEDICAL IMAGING 2008
Subtitle of host publication17-19 February 2008, San Diego, California, USA / Image processing
EditorsJM Reinhardt, JPW Pluim
Place of PublicationBELLINGHAM
Number of pages11
ISBN (Print)9780819470980
Publication statusPublished - 2008
EventMedical Imaging 2008 Conference - San Diego
Duration: 17 Feb 200819 Feb 2008


ConferenceMedical Imaging 2008 Conference
CitySan Diego


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