Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

TY - JOUR

T1 - Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

AU - Schoppet, M

AU - Shanahan, C M

PY - 2008/5

Y1 - 2008/5

N2 - Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PPi), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PPi by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels

AB - Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PPi), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PPi by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels

U2 - 10.1038/ki.2008.104

DO - 10.1038/ki.2008.104

M3 - Editorial

VL - 73

SP - 989

EP - 991

JO - Kidney International

JF - Kidney International

IS - 9

ER -