Abstract
Complex fractionated atrial electrograms (CFAEs)
are often used as a clinical marker for re-entrant drivers
of atrial fibrillation. However, outcomes of clinical ablation
procedures based on CFAEs are controversial and the mechanistic
links between fractionation, re-entrant activity and
the characteristics of the atrial substrate are not completely
understood. We explore such links by simulating electrograms
arising from both normal and re-entrant electrical activity
in atrial tissue models. 2D and 3D tissue geometries with a
range of conditions for intracellular coupling and myofiber
orientation fields were studied. Electrograms were fractionated
in the presence of complex atrial fiber fields and in 3D irregular
geometries, due to far-field excitations. The complexity of the
local electrical activity was not a strong determinant of the
degree of fractionation. These results suggest that electrogram
fractionation is more strongly linked to atrial substrate characteristics
(including tissue geometry, fiber orientation and degree
of intercelullar coupling) than to the electrical activation pattern
sustaining atrial fibrillation.
Original language | English |
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Title of host publication | Annual International Conference of the IEEE Engineering in Medicine & Biology Society |
Publisher | Institute of Electrical and Electronics Engineers ( IEEE ) |
Pages | 1587-1590 |
Number of pages | 4 |
Volume | 2014 |
ISBN (Print) | 9781424479276 |
DOIs | |
Publication status | Published - Sept 2014 |
Event | 36th Annual International Conference of the IEEE Engineering in Medicine & Biology - Chicago, IL, United States Duration: 26 Aug 2014 → 30 Aug 2014 |
Conference
Conference | 36th Annual International Conference of the IEEE Engineering in Medicine & Biology |
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Country/Territory | United States |
City | Chicago, IL |
Period | 26/08/2014 → 30/08/2014 |