TY - JOUR
T1 - Role of axonal transport in neurodegenerative diseases
AU - De Vos, K J
AU - Grierson, A J
AU - Ackerley, S
AU - Miller, C C J
PY - 2008
Y1 - 2008
N2 - Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease
AB - Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease
U2 - 10.1146/annurev.neuro.31.061307.090711
DO - 10.1146/annurev.neuro.31.061307.090711
M3 - Literature review
VL - 31
SP - 151
EP - 173
JO - Annual Review of Neuroscience
JF - Annual Review of Neuroscience
ER -
