TY - JOUR
T1 - Role of Cellular Metabolism during Candida-Host Interactions
AU - Pellon, Aize
AU - Begum, Neelu
AU - Nasab, Shervin Dokht Sadeghi
AU - Harzandi, Azadeh
AU - Shoaie, Saeed
AU - Moyes, David L.
N1 - Funding Information:
This review was supported by the Engineering and Physical Sciences Research Council (EPSRC) EP/S001301/1 and BBSRC grant-BB/S016899/1. D.L.M. and S.S. are further supported by Unilever and Sanofi.
Funding Information:
Funding: This review was supported by the Engineering and Physical Sciences Research Council (EPSRC) EP/S001301/1 and BBSRC grant -BB/S016899/1. D.L.M. and S.S. are further supported by Unilever and Sanofi.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2
Y1 - 2022/2
N2 - Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importance of metabolism and nutrient availability for fungi-host interactions have been highlighted. Upon activation, immune and other host cells reshape their metabolism to fulfil the energy-demanding process of generating an immune response. This includes macrophage upregulation of glucose uptake and processing via aerobic glycolysis. On the other side, Candida modulates its metabolic pathways to adapt to the usually hostile environment in the host, such as the lumen of phagolysosomes. Further understanding on metabolic interactions between host and fungal cells would potentially lead to novel/enhanced antifungal therapies to fight these infections. Therefore, this review paper focuses on how cellular metabolism, of both host cells and Candida, and the nutritional environment impact on the interplay between host and fungal cells.
AB - Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importance of metabolism and nutrient availability for fungi-host interactions have been highlighted. Upon activation, immune and other host cells reshape their metabolism to fulfil the energy-demanding process of generating an immune response. This includes macrophage upregulation of glucose uptake and processing via aerobic glycolysis. On the other side, Candida modulates its metabolic pathways to adapt to the usually hostile environment in the host, such as the lumen of phagolysosomes. Further understanding on metabolic interactions between host and fungal cells would potentially lead to novel/enhanced antifungal therapies to fight these infections. Therefore, this review paper focuses on how cellular metabolism, of both host cells and Candida, and the nutritional environment impact on the interplay between host and fungal cells.
KW - Candida albicans
KW - Epithelial cells
KW - Glucose
KW - Glycolysis
KW - Immunometabolism
KW - Macrophages
KW - Metabolism
KW - Moonlighting proteins
UR - http://www.scopus.com/inward/record.url?scp=85123979623&partnerID=8YFLogxK
U2 - 10.3390/pathogens11020184
DO - 10.3390/pathogens11020184
M3 - Review article
AN - SCOPUS:85123979623
SN - 2076-0817
VL - 11
JO - Pathogens
JF - Pathogens
IS - 2
M1 - 184
ER -