Role of helix-loop-helix proteins during differentiation of erythroid cells

Archana Anantharaman; I-Ju Lin; Joeva Barrow; Shermi Y Liang; Jude Masannat; John Strouboulis; Suming Huang; Jörg Bungert

doi:10.1128/MCB.01186-10

Role of helix-loop-helix proteins during differentiation of erythroid cells

Archana Anantharaman, I-Ju Lin, Joeva Barrow, Shermi Y Liang, Jude Masannat, John Strouboulis, Suming Huang, Jörg Bungert

Comprehensive Cancer Centre

University of Florida

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

Original language	English
Pages (from-to)	1332-43
Number of pages	12
Journal	Molecular and Cellular Biology
Volume	31
Issue number	7
DOIs	https://doi.org/10.1128/MCB.01186-10
Publication status	Published - Apr 2011

Keywords

Animals
Cell Differentiation/genetics
Erythroid Cells/cytology
Gene Expression Regulation
Globins/genetics
Helix-Loop-Helix Motifs
Humans
Transcription Factors/chemistry

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10.1128/MCB.01186-10

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title = "Role of helix-loop-helix proteins during differentiation of erythroid cells",

abstract = "Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.",

keywords = "Animals, Cell Differentiation/genetics, Erythroid Cells/cytology, Gene Expression Regulation, Globins/genetics, Helix-Loop-Helix Motifs, Humans, Transcription Factors/chemistry",

author = "Archana Anantharaman and I-Ju Lin and Joeva Barrow and Liang, {Shermi Y} and Jude Masannat and John Strouboulis and Suming Huang and J{\"o}rg Bungert",

year = "2011",

month = apr,

doi = "10.1128/MCB.01186-10",

language = "English",

volume = "31",

pages = "1332--43",

journal = "Molecular and Cellular Biology",

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T1 - Role of helix-loop-helix proteins during differentiation of erythroid cells

AU - Anantharaman, Archana

AU - Lin, I-Ju

AU - Barrow, Joeva

AU - Liang, Shermi Y

AU - Masannat, Jude

AU - Strouboulis, John

AU - Huang, Suming

AU - Bungert, Jörg

PY - 2011/4

Y1 - 2011/4

N2 - Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

AB - Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

KW - Animals

KW - Cell Differentiation/genetics

KW - Erythroid Cells/cytology

KW - Gene Expression Regulation

KW - Globins/genetics

KW - Helix-Loop-Helix Motifs

KW - Humans

KW - Transcription Factors/chemistry

U2 - 10.1128/MCB.01186-10

DO - 10.1128/MCB.01186-10

M3 - Review article

C2 - 21282467

SN - 0270-7306

VL - 31

SP - 1332

EP - 1343

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

IS - 7

ER -

Role of helix-loop-helix proteins during differentiation of erythroid cells

Abstract

Keywords

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