Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis

TY - JOUR

T1 - Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis

AU - Zhou, Boda

AU - Margariti, Andriana

AU - Zeng, Lingfang

AU - Xu, Qingbo

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from lysine residues of histone proteins, a modification that results in epigenetic modulation of gene expression. Although originally shown to be involved in cancer and neurological disease, HDACs are also found to play crucial roles in arteriosclerosis. This review summarizes the effects of HDACs and HDAC inhibitors on proliferation, migration, and apoptosis of endothelial and smooth muscle cells. In addition, an updated discussion of HDACs' recently discovered effects on stem cell differentiation and atherosclerosis is provided. Overall, HDACs appear to be promising therapeutic targets for the treatment of arteriosclerosis and other cardiovascular diseases.

AB - Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from lysine residues of histone proteins, a modification that results in epigenetic modulation of gene expression. Although originally shown to be involved in cancer and neurological disease, HDACs are also found to play crucial roles in arteriosclerosis. This review summarizes the effects of HDACs and HDAC inhibitors on proliferation, migration, and apoptosis of endothelial and smooth muscle cells. In addition, an updated discussion of HDACs' recently discovered effects on stem cell differentiation and atherosclerosis is provided. Overall, HDACs appear to be promising therapeutic targets for the treatment of arteriosclerosis and other cardiovascular diseases.

U2 - 10.1093/cvr/cvr003

DO - 10.1093/cvr/cvr003

M3 - Literature review

SN - 1755-3245

VL - 90

SP - 413

EP - 420

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -