Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis

Research output: Contribution to journalLiterature reviewpeer-review

75 Citations (Scopus)

Abstract

Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from lysine residues of histone proteins, a modification that results in epigenetic modulation of gene expression. Although originally shown to be involved in cancer and neurological disease, HDACs are also found to play crucial roles in arteriosclerosis. This review summarizes the effects of HDACs and HDAC inhibitors on proliferation, migration, and apoptosis of endothelial and smooth muscle cells. In addition, an updated discussion of HDACs' recently discovered effects on stem cell differentiation and atherosclerosis is provided. Overall, HDACs appear to be promising therapeutic targets for the treatment of arteriosclerosis and other cardiovascular diseases.
Original languageEnglish
Pages (from-to)413 - 420
Number of pages8
JournalCardiovascular Research
Volume90
Issue number3
DOIs
Publication statusPublished - 1 Jun 2011

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