Role of polarized cell divisions in zebrafish neural tube formation

TY - JOUR

T1 - Role of polarized cell divisions in zebrafish neural tube formation

AU - Clarke, Jon

PY - 2009/4

Y1 - 2009/4

N2 - Development of epithelial cell polarity and morphogenesis of a central lumen are essential prerequisites for the formation of the vertebrate neural tube. In teleost fish embryos this first involves the formation of a solid neural rod structure that then undergoes a process of cavitation to form a lumen. This process is initiated from a neural plate that has a distinct organization compared to other vertebrates, and involves complex cell intercalations and rearrangements. A key element is a mode of polarized cell division that generates daughters with mirror-image apico-basal polarity. These mirror-symmetric divisions have powerful morphogenetic influence because when they occur in ectopic locations they orchestrate the development of ectopic apical and basal specializations and the development of ectopic neural tubes.

AB - Development of epithelial cell polarity and morphogenesis of a central lumen are essential prerequisites for the formation of the vertebrate neural tube. In teleost fish embryos this first involves the formation of a solid neural rod structure that then undergoes a process of cavitation to form a lumen. This process is initiated from a neural plate that has a distinct organization compared to other vertebrates, and involves complex cell intercalations and rearrangements. A key element is a mode of polarized cell division that generates daughters with mirror-image apico-basal polarity. These mirror-symmetric divisions have powerful morphogenetic influence because when they occur in ectopic locations they orchestrate the development of ectopic apical and basal specializations and the development of ectopic neural tubes.

KW - Animals

KW - Cell Polarity

KW - Neurons

KW - Neural Tube

KW - Epithelium

KW - Zebrafish

KW - Cell Division

U2 - 10.1016/j.conb.2009.04.010

DO - 10.1016/j.conb.2009.04.010

M3 - Article

C2 - 19447605

SN - 1873-6882

VL - 19

SP - 134

EP - 138

JO - CURRENT OPINION IN NEUROBIOLOGY

JF - CURRENT OPINION IN NEUROBIOLOGY

IS - 2

ER -