Role of reactive oxygen species in myocardial remodeling

TY - JOUR

T1 - Role of reactive oxygen species in myocardial remodeling

AU - Zhang, Min

AU - Shah, Ajay M.

PY - 2007/3

Y1 - 2007/3

N2 - Adverse cardiac remodeling is a fundamental process in the progression to chronic heart failure. Although the mechanisms underlying cardiac remodeling are multi-factorial, a significant body of evidence points to the crucial roles of increased reactive oxygen species. This article reviews recent advances in delineating the different sources of production for reactive oxygen species (namely mitochondria, xanthine oxidase, uncoupled nitric oxide synthases, and NADPH oxidases) that may be involved in cardiac remodeling and the aspects of the remodeling process that they affect. These data could suggest new ways of targeting redox pathways for the prevention and treatment of adverse cardiac remodeling

AB - Adverse cardiac remodeling is a fundamental process in the progression to chronic heart failure. Although the mechanisms underlying cardiac remodeling are multi-factorial, a significant body of evidence points to the crucial roles of increased reactive oxygen species. This article reviews recent advances in delineating the different sources of production for reactive oxygen species (namely mitochondria, xanthine oxidase, uncoupled nitric oxide synthases, and NADPH oxidases) that may be involved in cardiac remodeling and the aspects of the remodeling process that they affect. These data could suggest new ways of targeting redox pathways for the prevention and treatment of adverse cardiac remodeling

U2 - 10.1007/s11897-007-0022-5

DO - 10.1007/s11897-007-0022-5

M3 - Article

VL - 4

SP - 26

EP - 30

JO - Current Heart Failure Reports

JF - Current Heart Failure Reports

IS - 1

ER -