Role of the extracellular matrix in regulating stem cell fate

Fiona M Watt; Wilhelm T S Huck

doi:10.1038/nrm3620

Role of the extracellular matrix in regulating stem cell fate

Fiona M Watt, Wilhelm T S Huck

Gene Therapy and Regenerative Medicine

Research output: Contribution to journal › Article › peer-review

723 Citations (Scopus)

Abstract

The field of stem cells and regenerative medicine offers considerable promise as a means of delivering new treatments for a wide range of diseases. In order to maximize the effectiveness of cell-based therapies - whether stimulating expansion of endogenous cells or transplanting cells into patients - it is essential to understand the environmental (niche) signals that regulate stem cell behaviour. One of those signals is from the extracellular matrix (ECM). New technologies have offered insights into how stem cells sense signals from the ECM and how they respond to these signals at the molecular level, which ultimately regulate their fate.

Original language	English
Pages (from-to)	467-473
Number of pages	7
Journal	NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume	14
Issue number	8
DOIs	https://doi.org/10.1038/nrm3620
Publication status	Published - Aug 2013

Keywords

Animals
Cell Communication
Cell Differentiation
Cell Lineage
Extracellular Matrix
Humans
Membrane Fluidity
Models, Biological
Stem Cell Niche
Stem Cells

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10.1038/nrm3620

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KW - Animals

KW - Cell Communication

KW - Cell Differentiation

KW - Cell Lineage

KW - Extracellular Matrix

KW - Humans

KW - Membrane Fluidity

KW - Models, Biological

KW - Stem Cell Niche

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Role of the extracellular matrix in regulating stem cell fate

Abstract

Keywords

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