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Role of the lysophosphatidylinositol/GPR55 axis in cancer

Research output: Contribution to journalReview articlepeer-review

Marco Falasca, Riccardo Ferro

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalAdvances in biological regulation
Volume60
Early online date28 Oct 2015
DOIs
Accepted/In press2 Oct 2015
E-pub ahead of print28 Oct 2015
PublishedJan 2016

King's Authors

Abstract

Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI. Several investigations have demonstrated that the signalling pathways activated by LPI through its receptor GPR55 play a pivotal role in different cancer type. This review focuses on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential therapeutic exploitation.

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