Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

Aina Brunet; Chrysostomos Tornari; Akunnah Ezebuiro; Robert Kennedy; Steve E.J. Connor; Richard Oakley; Jean Pierre Jeannon; Asit Arora; Aleix Rovira; Ricard Simo

doi:10.1177/01945998211033523

Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

Aina Brunet^*, Chrysostomos Tornari, Akunnah Ezebuiro, Robert Kennedy, Steve E.J. Connor, Richard Oakley, Jean Pierre Jeannon, Asit Arora, Aleix Rovira, Ricard Simo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study Design: Case series with chart review. Setting: Department of Otorhinolaryngology, Head and Neck Surgery, Guy’s Hospital, London, United Kingdom. Methods: A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results: Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion: Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI.

Original language	English
Journal	Otolaryngology - Head and Neck Surgery (United States)
DOIs	https://doi.org/10.1177/01945998211033523 https://doi.org/doi.org/10.1177/01945998211033523
Publication status	Published - 2021

Keywords

laryngeal squamous cell carcinoma
laryngectomy
thyroid gland

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{6d5674a4b4004808945eb01ac596582e,

title = "Role of Thyroidectomy in Recurrent Laryngeal Carcinoma",

abstract = "Objective: Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study Design: Case series with chart review. Setting: Department of Otorhinolaryngology, Head and Neck Surgery, Guy{\textquoteright}s Hospital, London, United Kingdom. Methods: A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results: Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion: Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI.",

keywords = "laryngeal squamous cell carcinoma, laryngectomy, thyroid gland",

author = "Aina Brunet and Chrysostomos Tornari and Akunnah Ezebuiro and Robert Kennedy and Connor, {Steve E.J.} and Richard Oakley and Jeannon, {Jean Pierre} and Asit Arora and Aleix Rovira and Ricard Simo",

note = "Funding Information: Funding source: Robert Kennedy is funded by the National Institute for Health Research (NIHR) (Academic Clinical Lectureship) for this research project. The views expressed are those of the author and not necessarily those of the NHS, the NIHR, the Department of Health and Social Care, or Public Health England. Publisher Copyright: {\textcopyright} American Academy of Otolaryngology–Head and Neck Surgery Foundation 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

doi = "10.1177/01945998211033523",

language = "English",

journal = "Otolaryngology - Head and Neck Surgery (United States)",

issn = "0194-5998",

publisher = "Sage Publications",

}

TY - JOUR

T1 - Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

AU - Brunet, Aina

AU - Tornari, Chrysostomos

AU - Ezebuiro, Akunnah

AU - Kennedy, Robert

AU - Connor, Steve E.J.

AU - Oakley, Richard

AU - Jeannon, Jean Pierre

AU - Arora, Asit

AU - Rovira, Aleix

AU - Simo, Ricard

N1 - Funding Information: Funding source: Robert Kennedy is funded by the National Institute for Health Research (NIHR) (Academic Clinical Lectureship) for this research project. The views expressed are those of the author and not necessarily those of the NHS, the NIHR, the Department of Health and Social Care, or Public Health England. Publisher Copyright: © American Academy of Otolaryngology–Head and Neck Surgery Foundation 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Objective: Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study Design: Case series with chart review. Setting: Department of Otorhinolaryngology, Head and Neck Surgery, Guy’s Hospital, London, United Kingdom. Methods: A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results: Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion: Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI.

AB - Objective: Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study Design: Case series with chart review. Setting: Department of Otorhinolaryngology, Head and Neck Surgery, Guy’s Hospital, London, United Kingdom. Methods: A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results: Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion: Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI.

KW - laryngeal squamous cell carcinoma

KW - laryngectomy

KW - thyroid gland

UR - http://www.scopus.com/inward/record.url?scp=85112781390&partnerID=8YFLogxK

U2 - 10.1177/01945998211033523

DO - 10.1177/01945998211033523

M3 - Article

AN - SCOPUS:85112781390

SN - 0194-5998

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

ER -

Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

Abstract

Keywords

UN SDGs

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