Roles of histone deacetylases in angiogenic cellular processes

Dario Ummarino; Yi Li; Lingfang Zeng

doi:10.2174/22115528112019990003

Roles of histone deacetylases in angiogenic cellular processes

Dario Ummarino, Yi Li, Lingfang Zeng^*

^*Corresponding author for this work

Cardiovascular Sciences

King's College London

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Histone Deacetylase enzymes (HDACs) are commonly known as epigenetic regulators of gene transcription, with indispensable roles in all biological processes. However, their activity is not limited solely to the chromatin modification but also to the deacetylation of cytoplasmic proteins and to act as signal transducers, with important implications in cell type-specific functions. This mini-review focuses on the roles of HDACs in angiogenesis, a process where a complex coordination of different cellular events, such as cell migration, survival, proliferation and differentiation, is required for the sprouting of blood vessels. Specific HDAC inhibitors have already been proved to be effective in the treatment of different tumors, indicating the importance of this family of enzymes as therapeutic targets in angiogenesis-related disorders.

Original language	English
Pages (from-to)	60-66
Number of pages	7
Journal	Current Angiogenesis
Volume	2
Issue number	1
DOIs	https://doi.org/10.2174/22115528112019990003
Publication status	Published - 1 Jan 2013

Keywords

Angiogenesis
Endothelial cells
HDACs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/22115528112019990003

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abstract = "Histone Deacetylase enzymes (HDACs) are commonly known as epigenetic regulators of gene transcription, with indispensable roles in all biological processes. However, their activity is not limited solely to the chromatin modification but also to the deacetylation of cytoplasmic proteins and to act as signal transducers, with important implications in cell type-specific functions. This mini-review focuses on the roles of HDACs in angiogenesis, a process where a complex coordination of different cellular events, such as cell migration, survival, proliferation and differentiation, is required for the sprouting of blood vessels. Specific HDAC inhibitors have already been proved to be effective in the treatment of different tumors, indicating the importance of this family of enzymes as therapeutic targets in angiogenesis-related disorders.",

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AU - Li, Yi

AU - Zeng, Lingfang

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N2 - Histone Deacetylase enzymes (HDACs) are commonly known as epigenetic regulators of gene transcription, with indispensable roles in all biological processes. However, their activity is not limited solely to the chromatin modification but also to the deacetylation of cytoplasmic proteins and to act as signal transducers, with important implications in cell type-specific functions. This mini-review focuses on the roles of HDACs in angiogenesis, a process where a complex coordination of different cellular events, such as cell migration, survival, proliferation and differentiation, is required for the sprouting of blood vessels. Specific HDAC inhibitors have already been proved to be effective in the treatment of different tumors, indicating the importance of this family of enzymes as therapeutic targets in angiogenesis-related disorders.

AB - Histone Deacetylase enzymes (HDACs) are commonly known as epigenetic regulators of gene transcription, with indispensable roles in all biological processes. However, their activity is not limited solely to the chromatin modification but also to the deacetylation of cytoplasmic proteins and to act as signal transducers, with important implications in cell type-specific functions. This mini-review focuses on the roles of HDACs in angiogenesis, a process where a complex coordination of different cellular events, such as cell migration, survival, proliferation and differentiation, is required for the sprouting of blood vessels. Specific HDAC inhibitors have already been proved to be effective in the treatment of different tumors, indicating the importance of this family of enzymes as therapeutic targets in angiogenesis-related disorders.

KW - Angiogenesis

KW - Endothelial cells

KW - HDACs

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M3 - Review article

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ER -

Roles of histone deacetylases in angiogenic cellular processes

Abstract

Keywords

UN SDGs

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