Abstract
Leucocytes migrate into and out of blood vessels at multiple points during their development and maturation, and during immune surveillance. In response to tissue damage and infection, they are rapidly recruited through the endothelium lining blood vessels into the tissues. Leukaemia cells also move in and out of the bloodstream during leukaemia progression. Rho GTPases are intracellular signalling proteins that regulate cytoskeletal dynamics and are key coordinators of cell migration. Here, we describe how different members of the Rho GTPase family act in leucocytes and leukaemia cells to regulate steps of transendothelial migration. We discuss how inhibitors of Rho signalling could be used to reduce leucocyte or leukaemia cell entry into tissues.
| Original language | English |
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| Article number | 20130013 |
| Pages (from-to) | N/A |
| Number of pages | 6 |
| Journal | Philosophical Transactions of the Royal Society of London Series B: Biological Sciences |
| Volume | 368 |
| Issue number | 1629 |
| DOIs | |
| Publication status | Published - 5 Nov 2013 |