Abstract
The heart contains not only cardiomyocytes but also other cell types such as endothelial cells and fibroblasts. Functional crosstalk among these cell types is important for normal cardiac function and is also involved in disease pathophysiology. Recent data indicate that redox signalling within and between endothelial cells and cardiomyocytes, both through direct and indirect mechanisms, is an important aspect of the functional communication between these cell types. Such signalling influences contractile function, cardiomyocyte growth, hypertrophy, angiogenesis, and fibrosis, and may play an important role in cardiac remodelling in disease.
| Original language | English |
|---|---|
| Pages (from-to) | 249-257 |
| Number of pages | 9 |
| Journal | Cardiovascular Research |
| Volume | 102 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 May 2014 |
Keywords
- Cardiomyocyte
- Endothelial cell
- Paracrine
- Redox signalling
- NADPH oxidase
- Nitric oxide
- NITRIC-OXIDE SYNTHASE
- END RULE PATHWAY
- PRESERVED EJECTION FRACTION
- LEFT-VENTRICULAR RELAXATION
- CHRONIC PRESSURE-OVERLOAD
- HEART-FAILURE
- NADPH OXIDASE
- OXIDATIVE STRESS
- REACTIVE OXYGEN
- GROWTH-FACTOR