Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1

Audrey Melvin, Claire Adams, Catherine Flanagan, Lisa Gaff, Barbara Gratton, Fiona Gribble, Geoffrey Roberts, Robert K. Semple, Stephen O'Rahilly, Francesco Rubino, Anna Stears, David B. Savage

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
122 Downloads (Pure)


Context: Familial partial lipodystrophy type 1 (FPLD1) is an extreme form of central adiposity, with peripheral lipodystrophy associated with severe manifestations of the metabolic syndrome, often poorly responsive to standard therapeutic approaches. Body mass index in FPLD1 varies but, in many cases, is below the level at which metabolic surgery is usually considered as a therapeutic option.

Design: We detailed the metabolic response to gastric bypass surgery of three patients with FPLD1, refractory to medical therapy.

Results: Roux-en-Y gastric bypass (RYGB) was associated with weight loss and substantial improvements in glycemic control and insulin sensitivity. All three patients were able to stop using insulin. Glucose tolerance testing in one patient demonstrated an increase in L-cell-derived gut hormone responses postoperatively.

Conclusion: RYGB surgery substantially improved glycemic control in three patients with FPLD1, two of whom had body mass indices below 30 kg/m2. RYGB should be considered in patients with partial lipodystrophy and refractory metabolic disease.

Original languageEnglish
Pages (from-to)3616-3620
Number of pages5
JournalThe Journal of clinical endocrinology and metabolism
Issue number10
Early online date26 Jul 2017
Publication statusPublished - 1 Oct 2017


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