Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

Lucie Giblin, Fergus P. McCarthy, Carolyn Gill, Paul T. Seed, Kate Bramham, Anna Brockbank, Lucy C. Chappell, Andrew H. Shennan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks’ gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsia requiring delivery within 14 days (specificity 95.0% (95% CI 91.7–97.2%), positive predictive value 50 (95% CI 30.6–69.4%), positive likelihood ratio 10.7 (5.8–20).

Original languageEnglish
Pages (from-to)35-37
Number of pages3
JournalPregnancy Hypertension
Volume21
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Diagnostic
  • PlGF
  • Pre-eclampsia
  • Test performance

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