Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres

Mark N. Wallace; Christian J. Sumner; Joel I. Berger; Peter A. McNaughton; Alan R. Palmer

doi:10.1016/j.neulet.2021.135705

Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres

Mark N. Wallace^*, Christian J. Sumner, Joel I. Berger, Peter A. McNaughton, Alan R. Palmer

^*Corresponding author for this work

Wolfson SPaRC

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in at least one type of afferent auditory nerve fibre in anaesthetised guinea pigs. In control animals there was a bimodal distribution of spontaneous rates, but the position of the second mode was different depending upon whether the fibres responded best to high (> 4 kHz) or low (≤4 kHz) frequency tonal stimulation. The simplest and most reliable way of inducing tinnitus in experimental animals is to administer a high dose of sodium salicylate. The distribution of the spontaneous firing rates was different when salicylate (350 mg/kg) was administered, even when the sample was matched for the distribution of characteristic frequencies in the control population. The proportion of medium spontaneous rate fibres (MSR, 1≤ spikes/s ≤20) increased while the proportion of the highest, high spontaneous firing rate fibres (HSR, > 80 spikes/s) decreased following salicylate. The median rate fell from 64.7 spikes/s (control) to 35.4 spikes/s (salicylate); a highly significant change (Kruskal-Wallis test p < 0.001). When the changes were compared with various models of statistical probability, the most accurate model was one where most HSR fibres decreased their firing rate by 32 spikes/s. Thus, we have shown a reduction in the firing rate of HSR fibres that may be related to tinnitus.

Original language	English
Article number	135705
Journal	Neuroscience Letters
Volume	747
DOIs	https://doi.org/10.1016/j.neulet.2021.135705
Publication status	Published - 16 Mar 2021

Keywords

Ototoxicity
Phantom limb sensation
Temporary tinnitus
Tinnitus mechanisms
Vestibulocochlear nerve

Access to Document

10.1016/j.neulet.2021.135705

Cite this

@article{69d8eb93389e4a35be24400918523761,

title = "Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres",

abstract = "Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in at least one type of afferent auditory nerve fibre in anaesthetised guinea pigs. In control animals there was a bimodal distribution of spontaneous rates, but the position of the second mode was different depending upon whether the fibres responded best to high (> 4 kHz) or low (≤4 kHz) frequency tonal stimulation. The simplest and most reliable way of inducing tinnitus in experimental animals is to administer a high dose of sodium salicylate. The distribution of the spontaneous firing rates was different when salicylate (350 mg/kg) was administered, even when the sample was matched for the distribution of characteristic frequencies in the control population. The proportion of medium spontaneous rate fibres (MSR, 1≤ spikes/s ≤20) increased while the proportion of the highest, high spontaneous firing rate fibres (HSR, > 80 spikes/s) decreased following salicylate. The median rate fell from 64.7 spikes/s (control) to 35.4 spikes/s (salicylate); a highly significant change (Kruskal-Wallis test p < 0.001). When the changes were compared with various models of statistical probability, the most accurate model was one where most HSR fibres decreased their firing rate by 32 spikes/s. Thus, we have shown a reduction in the firing rate of HSR fibres that may be related to tinnitus.",

keywords = "Ototoxicity, Phantom limb sensation, Temporary tinnitus, Tinnitus mechanisms, Vestibulocochlear nerve",

author = "Wallace, {Mark N.} and Sumner, {Christian J.} and Berger, {Joel I.} and McNaughton, {Peter A.} and Palmer, {Alan R.}",

note = "Funding Information: This work was supported by the Medical Research Council grant [ MC_U135097127 ] and Action on Hearing Loss grant [ TRIH 2018 ] to CJS and PAM respectively. The funders had no role in study design, data collection and analysis, or decision to publish. Dr T.M. Shackleton developed customised software. Publisher Copyright: {\textcopyright} 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = mar,

day = "16",

doi = "10.1016/j.neulet.2021.135705",

language = "English",

volume = "747",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres

AU - Wallace, Mark N.

AU - Sumner, Christian J.

AU - Berger, Joel I.

AU - McNaughton, Peter A.

AU - Palmer, Alan R.

N1 - Funding Information: This work was supported by the Medical Research Council grant [ MC_U135097127 ] and Action on Hearing Loss grant [ TRIH 2018 ] to CJS and PAM respectively. The funders had no role in study design, data collection and analysis, or decision to publish. Dr T.M. Shackleton developed customised software. Publisher Copyright: © 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in at least one type of afferent auditory nerve fibre in anaesthetised guinea pigs. In control animals there was a bimodal distribution of spontaneous rates, but the position of the second mode was different depending upon whether the fibres responded best to high (> 4 kHz) or low (≤4 kHz) frequency tonal stimulation. The simplest and most reliable way of inducing tinnitus in experimental animals is to administer a high dose of sodium salicylate. The distribution of the spontaneous firing rates was different when salicylate (350 mg/kg) was administered, even when the sample was matched for the distribution of characteristic frequencies in the control population. The proportion of medium spontaneous rate fibres (MSR, 1≤ spikes/s ≤20) increased while the proportion of the highest, high spontaneous firing rate fibres (HSR, > 80 spikes/s) decreased following salicylate. The median rate fell from 64.7 spikes/s (control) to 35.4 spikes/s (salicylate); a highly significant change (Kruskal-Wallis test p < 0.001). When the changes were compared with various models of statistical probability, the most accurate model was one where most HSR fibres decreased their firing rate by 32 spikes/s. Thus, we have shown a reduction in the firing rate of HSR fibres that may be related to tinnitus.

AB - Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in at least one type of afferent auditory nerve fibre in anaesthetised guinea pigs. In control animals there was a bimodal distribution of spontaneous rates, but the position of the second mode was different depending upon whether the fibres responded best to high (> 4 kHz) or low (≤4 kHz) frequency tonal stimulation. The simplest and most reliable way of inducing tinnitus in experimental animals is to administer a high dose of sodium salicylate. The distribution of the spontaneous firing rates was different when salicylate (350 mg/kg) was administered, even when the sample was matched for the distribution of characteristic frequencies in the control population. The proportion of medium spontaneous rate fibres (MSR, 1≤ spikes/s ≤20) increased while the proportion of the highest, high spontaneous firing rate fibres (HSR, > 80 spikes/s) decreased following salicylate. The median rate fell from 64.7 spikes/s (control) to 35.4 spikes/s (salicylate); a highly significant change (Kruskal-Wallis test p < 0.001). When the changes were compared with various models of statistical probability, the most accurate model was one where most HSR fibres decreased their firing rate by 32 spikes/s. Thus, we have shown a reduction in the firing rate of HSR fibres that may be related to tinnitus.

KW - Ototoxicity

KW - Phantom limb sensation

KW - Temporary tinnitus

KW - Tinnitus mechanisms

KW - Vestibulocochlear nerve

UR - http://www.scopus.com/inward/record.url?scp=85100706558&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2021.135705

DO - 10.1016/j.neulet.2021.135705

M3 - Article

AN - SCOPUS:85100706558

SN - 0304-3940

VL - 747

JO - Neuroscience Letters

JF - Neuroscience Letters

M1 - 135705

ER -

Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this