Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases: Saliva and gastrointestinal diseases

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Objectives The early diagnosis and monitoring of Crohn’s disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG+CD). Subjects Unstimulated whole mouth saliva was collected from 93 subjects and analysed and immunoglobulin A (IgA), lactoferrin (LF) and myeloperoxidase (MPO) determined by ELISA. Markers of oxidative stress and antioxidant status were assayed spectrophotometrically. Results IgA was significantly (p<0.03) higher in experimental groups versus the control group. LF was significantly (P<0.01) higher in OFG+CD compared to CTRL and CD. Ferric reducing antioxidant power was lower (P≤0.009) in all experimental groups and advanced glycation end products were higher (P≤0.01) in CD and OFG+CD patients. Conclusion Oxidative stress is increased in saliva in CD and OFG. Although MPO, a product of inflammatory cells, was not significantly increased, there were increases in other innate immune markers, IgA and LF; which are also secreted by salivary glands. This study suggests that saliva might be utilized in monitoring CD and OFG but further longitudinal studies focused on analysing a panel of salivary markers are needed.
Original languageEnglish
Article number
JournalOral Diseases
Publication statusAccepted/In press - 25 Jun 2020

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