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Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration

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Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration. / Contessi Negrini, N; Angelova Volponi, A; Higgins, C A et al.

In: Materials Today Bio, Vol. 10, 100107, 03.2021.

Research output: Contribution to journalReview articlepeer-review

Harvard

Contessi Negrini, N, Angelova Volponi, A, Higgins, CA, Sharpe, PT & Celiz, AD 2021, 'Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration', Materials Today Bio, vol. 10, 100107. https://doi.org/10.1016/j.mtbio.2021.100107

APA

Contessi Negrini, N., Angelova Volponi, A., Higgins, C. A., Sharpe, P. T., & Celiz, A. D. (2021). Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration. Materials Today Bio, 10, [100107]. https://doi.org/10.1016/j.mtbio.2021.100107

Vancouver

Contessi Negrini N, Angelova Volponi A, Higgins CA, Sharpe PT, Celiz AD. Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration. Materials Today Bio. 2021 Mar;10. 100107. https://doi.org/10.1016/j.mtbio.2021.100107

Author

Contessi Negrini, N ; Angelova Volponi, A ; Higgins, C A et al. / Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration. In: Materials Today Bio. 2021 ; Vol. 10.

Bibtex Download

@article{da8e082ebccc41fd8a52a89315358d6a,
title = "Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration",
abstract = "Tissue engineering (TE) is a multidisciplinary research field aiming at the regeneration, restoration, or replacement of damaged tissues and organs. Classical TE approaches combine scaffolds, cells and soluble factors to fabricate constructs mimicking the native tissue to be regenerated. However, to date, limited success in clinical translations has been achieved by classical TE approaches, because of the lack of satisfactory biomorphological and biofunctional features of the obtained constructs. Developmental TE has emerged as a novel TE paradigm to obtain tissues and organs with correct biomorphology and biofunctionality by mimicking the morphogenetic processes leading to the tissue/organ generation in the embryo. Ectodermal appendages, for instance, develop in vivo by sequential interactions between epithelium and mesenchyme, in a process known as secondary induction. A fine artificial replication of these complex interactions can potentially lead to the fabrication of the tissues/organs to be regenerated. Successful developmental TE applications have been reported, in vitro and in vivo, for ectodermal appendages such as teeth, hair follicles and glands. Developmental TE strategies require an accurate selection of cell sources, scaffolds and cell culture configurations to allow for the correct replication of the in vivo morphogenetic cues. Herein, we describe and discuss the emergence of this TE paradigm by reviewing the achievements obtained so far in developmental TE 3D scaffolds for teeth, hair follicles, and salivary and lacrimal glands, with particular focus on the selection of biomaterials and cell culture configurations.",
keywords = "Cell coculture, Developmental, Epithelial-mesenchymal interaction, Gland regeneration, Hair follicle regeneration, tissue engineering, Tooth regeneration",
author = "{Contessi Negrini}, N and {Angelova Volponi}, A and Higgins, {C A} and Sharpe, {P T} and Celiz, {A D}",
note = "Funding Information: Confidence in Collaboration in Advanced Therapies Award - Project CiC007 (AC), UKRI Future Leaders Fellowship MR/S034757/1 (AC). Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.mtbio.2021.100107",
language = "English",
volume = "10",
journal = "Materials Today Bio",
issn = "2590-0064",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration

AU - Contessi Negrini, N

AU - Angelova Volponi, A

AU - Higgins, C A

AU - Sharpe, P T

AU - Celiz, A D

N1 - Funding Information: Confidence in Collaboration in Advanced Therapies Award - Project CiC007 (AC), UKRI Future Leaders Fellowship MR/S034757/1 (AC). Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - Tissue engineering (TE) is a multidisciplinary research field aiming at the regeneration, restoration, or replacement of damaged tissues and organs. Classical TE approaches combine scaffolds, cells and soluble factors to fabricate constructs mimicking the native tissue to be regenerated. However, to date, limited success in clinical translations has been achieved by classical TE approaches, because of the lack of satisfactory biomorphological and biofunctional features of the obtained constructs. Developmental TE has emerged as a novel TE paradigm to obtain tissues and organs with correct biomorphology and biofunctionality by mimicking the morphogenetic processes leading to the tissue/organ generation in the embryo. Ectodermal appendages, for instance, develop in vivo by sequential interactions between epithelium and mesenchyme, in a process known as secondary induction. A fine artificial replication of these complex interactions can potentially lead to the fabrication of the tissues/organs to be regenerated. Successful developmental TE applications have been reported, in vitro and in vivo, for ectodermal appendages such as teeth, hair follicles and glands. Developmental TE strategies require an accurate selection of cell sources, scaffolds and cell culture configurations to allow for the correct replication of the in vivo morphogenetic cues. Herein, we describe and discuss the emergence of this TE paradigm by reviewing the achievements obtained so far in developmental TE 3D scaffolds for teeth, hair follicles, and salivary and lacrimal glands, with particular focus on the selection of biomaterials and cell culture configurations.

AB - Tissue engineering (TE) is a multidisciplinary research field aiming at the regeneration, restoration, or replacement of damaged tissues and organs. Classical TE approaches combine scaffolds, cells and soluble factors to fabricate constructs mimicking the native tissue to be regenerated. However, to date, limited success in clinical translations has been achieved by classical TE approaches, because of the lack of satisfactory biomorphological and biofunctional features of the obtained constructs. Developmental TE has emerged as a novel TE paradigm to obtain tissues and organs with correct biomorphology and biofunctionality by mimicking the morphogenetic processes leading to the tissue/organ generation in the embryo. Ectodermal appendages, for instance, develop in vivo by sequential interactions between epithelium and mesenchyme, in a process known as secondary induction. A fine artificial replication of these complex interactions can potentially lead to the fabrication of the tissues/organs to be regenerated. Successful developmental TE applications have been reported, in vitro and in vivo, for ectodermal appendages such as teeth, hair follicles and glands. Developmental TE strategies require an accurate selection of cell sources, scaffolds and cell culture configurations to allow for the correct replication of the in vivo morphogenetic cues. Herein, we describe and discuss the emergence of this TE paradigm by reviewing the achievements obtained so far in developmental TE 3D scaffolds for teeth, hair follicles, and salivary and lacrimal glands, with particular focus on the selection of biomaterials and cell culture configurations.

KW - Cell coculture

KW - Developmental

KW - Epithelial-mesenchymal interaction

KW - Gland regeneration

KW - Hair follicle regeneration

KW - tissue engineering

KW - Tooth regeneration

UR - http://www.scopus.com/inward/record.url?scp=85103621932&partnerID=8YFLogxK

U2 - 10.1016/j.mtbio.2021.100107

DO - 10.1016/j.mtbio.2021.100107

M3 - Review article

C2 - 33889838

AN - SCOPUS:85103621932

VL - 10

JO - Materials Today Bio

JF - Materials Today Bio

SN - 2590-0064

M1 - 100107

ER -

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