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Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies

Research output: Contribution to journalArticlepeer-review

Abdullah Fahad A. Alshamrani, Orlando Santoro, Timothy J. Prior, Mohammed A. Alamri, Graeme J. Stasiuk, Mark R.J. Elsegood, Carl Redshaw

Original languageEnglish
Pages (from-to)8302-8306
Number of pages5
JournalDalton Transactions
Volume50
Issue number24
DOIs
Published28 Jun 2021

Bibliographical note

Funding Information: The EPSRC (PRIF grant EP/S025537/1) and the Whitelaw Frater Cancer Trust are thanked for financial support. The Saudi Cultural Bureau is thanked for sponsorship (of AFA and MA). GJS would like to thank both the Medical Research Council (MR/T002573/1) and the Engineering and Physical Sciences Research Council (EP/V027549/1 and EP/T026367/1) for financial support. We also thank the EPSRC National Crystallographic Service Centre at Southampton for data. Publisher Copyright: © The Royal Society of Chemistry 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

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Abstract

Interaction of [Sc(OR)3] (R = iPr or triflate) withp-tert-butylcalix[n]arenes, wheren= 4, 6, or 8, affords a number of intriguing structural motifs, which are relatively non-toxic (cytotoxicity evaluated against cell lines HCT116 and HT-29) and a number were capable of the ring opening polymerization (ROP) of cyclohexene oxide.

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