Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina Faso

TY - JOUR

T1 - Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina Faso

AU - Koukounari, Artemis

AU - Gabrielli, Albis F

AU - Toure, Seydou

AU - Bosque-Oliva, Elisa

AU - Zhang, Yaobi

AU - Sellin, Bertrand

AU - Donnelly, Christl A

AU - Fenwick, Alan

AU - Webster, Joanne P

PY - 2007/9/1

Y1 - 2007/9/1

N2 - BACKGROUND: In sub-Saharan Africa, 112 million people are infected with Schistosoma haematobium, with the most intense infections in children 5-15 years old. METHODS: We describe a longitudinal epidemiological study that evaluates the relationship between S. haematobium infection and associated morbidity in children before and after the large-scale administration of praziquantel for schistosomiasis and albendazole for soil-transmitted helminths. RESULTS: At baseline, higher intensities of S. haematobium infection were observed in children with anemia and/or severe microhematuria, but there was no apparent association between the risk of undernutrition and intensity of S. haematobium infection. Significant reductions in the prevalence and intensity of S. haematobium infection 1 year after treatment were, however, observed. Children who benefited the most from anthelmintic treatment in terms of increased hemoglobin concentrations were those who had anemia at baseline and those with highly positive microhematuria scores at baseline. CONCLUSIONS: This study suggests that even a single round of mass chemotherapy can have a substantial impact on S. haematobium infection and its associated morbidity in children.

AB - BACKGROUND: In sub-Saharan Africa, 112 million people are infected with Schistosoma haematobium, with the most intense infections in children 5-15 years old. METHODS: We describe a longitudinal epidemiological study that evaluates the relationship between S. haematobium infection and associated morbidity in children before and after the large-scale administration of praziquantel for schistosomiasis and albendazole for soil-transmitted helminths. RESULTS: At baseline, higher intensities of S. haematobium infection were observed in children with anemia and/or severe microhematuria, but there was no apparent association between the risk of undernutrition and intensity of S. haematobium infection. Significant reductions in the prevalence and intensity of S. haematobium infection 1 year after treatment were, however, observed. Children who benefited the most from anthelmintic treatment in terms of increased hemoglobin concentrations were those who had anemia at baseline and those with highly positive microhematuria scores at baseline. CONCLUSIONS: This study suggests that even a single round of mass chemotherapy can have a substantial impact on S. haematobium infection and its associated morbidity in children.

KW - Adolescent

KW - Anemia

KW - Burkina Faso

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Feces

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Praziquantel

KW - Schistosomiasis haematobia

KW - Schistosomicides

U2 - 10.1086/520515

DO - 10.1086/520515

M3 - Article

C2 - 17674306

SN - 0022-1899

VL - 196

SP - 659

EP - 669

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

M1 - N/A

ER -