Schizophrenia during pregnancy Paola Dazzan

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose of review
A diagnosis of schizophrenia has significant implications for women of childbearing age, pregnant or
considering a pregnancy, ranging from sexual health, psychopharmacological treatment, to the occurrence
of negative pregnancy and foetal outcomes. We provide a short narrative review of recent papers focusing
on these issues.
Recent findings
Although pregnancy rates have been increasing in women with a diagnosis of schizophrenia, they also
tend to have altogether fewer pregnancies and fewer live births than women without this diagnosis, and
also higher rates of induced abortions.
Use of antipsychotics in pregnancy has also increased, and evidence suggests lack of significant
contraindications for their use in this period. However, drug levels monitoring may be recommended across
the three trimesters, as levels may change in relation to pregnancy-related physiology.
Monitoring of physical health is an increasingly crucial issue, given higher risk of gestational diabetes,
negative obstetric and infant outcomes in these women.
Summary
There is an urgent need to generate valid and reproducible research that could help implement appropriate
treatment protocols and relapse-prevention approaches, and interventions based on strong pharmaceutical
targets for the benefit of pregnant women with a diagnosis of schizophrenia, their families and their
children.
Keywords
antipsychotics, perinatal, pregnancy, schizophrenia
Original languageEnglish
JournalCurrent opinion in psychiatry
Publication statusAccepted/In press - 11 Feb 2022

Keywords

  • antipsychotics, perinatal, pregnancy, schizophrenia

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