Schizophrenia moderates the relationship between white matter integrity and cognition

Luis F.S. Castro-de-Araujo; Mathew Allin; Marco M. Picchioni; Colm Mcdonald; Christos Pantelis; Richard A.A. Kanaan

doi:10.1016/j.schres.2018.03.033

Schizophrenia moderates the relationship between white matter integrity and cognition

Luis F.S. Castro-de-Araujo, Mathew Allin, Marco M. Picchioni, Colm Mcdonald, Christos Pantelis, Richard A.A. Kanaan

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

137 Downloads (Pure)

Abstract

Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities.

Original language	English
Pages (from-to)	250-256
Number of pages	7
Journal	Schizophrenia Research
Volume	199
Early online date	28 Mar 2018
DOIs	https://doi.org/10.1016/j.schres.2018.03.033
Publication status	Published - 1 Sept 2018

Keywords

Cognitive tests
Linear models
Statistical models

Access to Document

10.1016/j.schres.2018.03.033Licence: CC BY

Schizophrenia moderates the relationship_CASTRO-DE-ARAUJO_Accepted18March2018_GOLD VoR (CC BY)Final published version, 908 KBLicence: CC BY

http://www.sciencedirect.com/science/article/pii/S0920996418301865

Cite this

@article{44c809e605c64fe0a339e308e2ed89a8,

title = "Schizophrenia moderates the relationship between white matter integrity and cognition",

abstract = "Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities.",

keywords = "Cognitive tests, Linear models, Statistical models",

author = "Castro-de-Araujo, {Luis F.S.} and Mathew Allin and Picchioni, {Marco M.} and Colm Mcdonald and Christos Pantelis and Kanaan, {Richard A.A.}",

year = "2018",

month = sep,

day = "1",

doi = "10.1016/j.schres.2018.03.033",

language = "English",

volume = "199",

pages = "250--256",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

}

TY - JOUR

T1 - Schizophrenia moderates the relationship between white matter integrity and cognition

AU - Castro-de-Araujo, Luis F.S.

AU - Allin, Mathew

AU - Picchioni, Marco M.

AU - Mcdonald, Colm

AU - Pantelis, Christos

AU - Kanaan, Richard A.A.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities.

AB - Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities.

KW - Cognitive tests

KW - Linear models

KW - Statistical models

U2 - 10.1016/j.schres.2018.03.033

DO - 10.1016/j.schres.2018.03.033

M3 - Article

SN - 0920-9964

VL - 199

SP - 250

EP - 256

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Schizophrenia moderates the relationship between white matter integrity and cognition

Abstract

Keywords

Access to Document

Fingerprint

Cite this