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Schizophrenia moderates the relationship between white matter integrity and cognition

Research output: Contribution to journalArticle

Luis F.S. Castro-de-Araujo, Mathew Allin, Marco M. Picchioni, Colm Mcdonald, Christos Pantelis, Richard A.A. Kanaan

Original languageEnglish
Pages (from-to)250-256
Number of pages7
JournalSchizophrenia Research
Early online date28 Mar 2018
Accepted/In press18 Mar 2018
E-pub ahead of print28 Mar 2018
Published1 Sep 2018


King's Authors


Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities.

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