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Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study

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Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study. / MacCabe, James; Lambe, M.P.; Cnattingius, S.; Torrång, A.; Sham, P.C.; David, A.S.; Murray, R.M.; Hultman, C.M.

In: Psychological Medicine, Vol. 38, No. 8, 08.2008, p. 1133-1140.

Research output: Contribution to journalArticle

Harvard

MacCabe, J, Lambe, MP, Cnattingius, S, Torrång, A, Sham, PC, David, AS, Murray, RM & Hultman, CM 2008, 'Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study', Psychological Medicine, vol. 38, no. 8, pp. 1133-1140. https://doi.org/10.1017/S0033291707002048

APA

MacCabe, J., Lambe, M. P., Cnattingius, S., Torrång, A., Sham, P. C., David, A. S., ... Hultman, C. M. (2008). Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study. Psychological Medicine, 38(8), 1133-1140. https://doi.org/10.1017/S0033291707002048

Vancouver

MacCabe J, Lambe MP, Cnattingius S, Torrång A, Sham PC, David AS et al. Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study. Psychological Medicine. 2008 Aug;38(8):1133-1140. https://doi.org/10.1017/S0033291707002048

Author

MacCabe, James ; Lambe, M.P. ; Cnattingius, S. ; Torrång, A. ; Sham, P.C. ; David, A.S. ; Murray, R.M. ; Hultman, C.M. / Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study. In: Psychological Medicine. 2008 ; Vol. 38, No. 8. pp. 1133-1140.

Bibtex Download

@article{545fb13eb49d46b686b746f18ce77540,
title = "Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study",
abstract = "Background. There is abundant evidence that schizophrenia is associated with cognitive deficits in childhood. However, previous studies investigating school performance have been inconclusive. Furthermore, there are several biological and social factors that could confound the association. We investigated whether school performance at age 16 is associated with risk of adult schizophrenia and other psychoses in a large national cohort, while controlling for multiple confounders. Method. Using a national sample of 907011 individuals born in Sweden between 1973 and 1983, we used Cox regression to assess whether scholastic achievement at age 15-16 predicted hospital admission for psychosis between ages 17 and 31, adjusting for potential confounders. Results. Poor school performance was associated with increased rates of schizophrenia [hazard ratio (HR) 3.9, 95{\%}, confidence interval (Cl) 2.8-5.3], schizo-affective disorder (HR 4.2, 95 {\%} CI 1.9-9.1) and other psychoses (HR 3.0, 95{\%} CI 2.3-4.0). Receiving the lowest (E) grade was significantly associated with risk for schizophrenia and other psychoses in every school subject. There was no evidence of confounding by migrant status, low birthweight, hypoxia, parental education level or socio-economic group. Conclusions. Poor school performance across all domains is strongly associated with risk for schizophrenia and other psychoses.",
author = "James MacCabe and M.P. Lambe and S. Cnattingius and A. Torr{\aa}ng and P.C. Sham and A.S. David and R.M. Murray and C.M. Hultman",
year = "2008",
month = "8",
doi = "10.1017/S0033291707002048",
language = "English",
volume = "38",
pages = "1133--1140",
journal = "Psychological Medicine",
issn = "0033-2917",
number = "8",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study

AU - MacCabe, James

AU - Lambe, M.P.

AU - Cnattingius, S.

AU - Torrång, A.

AU - Sham, P.C.

AU - David, A.S.

AU - Murray, R.M.

AU - Hultman, C.M.

PY - 2008/8

Y1 - 2008/8

N2 - Background. There is abundant evidence that schizophrenia is associated with cognitive deficits in childhood. However, previous studies investigating school performance have been inconclusive. Furthermore, there are several biological and social factors that could confound the association. We investigated whether school performance at age 16 is associated with risk of adult schizophrenia and other psychoses in a large national cohort, while controlling for multiple confounders. Method. Using a national sample of 907011 individuals born in Sweden between 1973 and 1983, we used Cox regression to assess whether scholastic achievement at age 15-16 predicted hospital admission for psychosis between ages 17 and 31, adjusting for potential confounders. Results. Poor school performance was associated with increased rates of schizophrenia [hazard ratio (HR) 3.9, 95%, confidence interval (Cl) 2.8-5.3], schizo-affective disorder (HR 4.2, 95 % CI 1.9-9.1) and other psychoses (HR 3.0, 95% CI 2.3-4.0). Receiving the lowest (E) grade was significantly associated with risk for schizophrenia and other psychoses in every school subject. There was no evidence of confounding by migrant status, low birthweight, hypoxia, parental education level or socio-economic group. Conclusions. Poor school performance across all domains is strongly associated with risk for schizophrenia and other psychoses.

AB - Background. There is abundant evidence that schizophrenia is associated with cognitive deficits in childhood. However, previous studies investigating school performance have been inconclusive. Furthermore, there are several biological and social factors that could confound the association. We investigated whether school performance at age 16 is associated with risk of adult schizophrenia and other psychoses in a large national cohort, while controlling for multiple confounders. Method. Using a national sample of 907011 individuals born in Sweden between 1973 and 1983, we used Cox regression to assess whether scholastic achievement at age 15-16 predicted hospital admission for psychosis between ages 17 and 31, adjusting for potential confounders. Results. Poor school performance was associated with increased rates of schizophrenia [hazard ratio (HR) 3.9, 95%, confidence interval (Cl) 2.8-5.3], schizo-affective disorder (HR 4.2, 95 % CI 1.9-9.1) and other psychoses (HR 3.0, 95% CI 2.3-4.0). Receiving the lowest (E) grade was significantly associated with risk for schizophrenia and other psychoses in every school subject. There was no evidence of confounding by migrant status, low birthweight, hypoxia, parental education level or socio-economic group. Conclusions. Poor school performance across all domains is strongly associated with risk for schizophrenia and other psychoses.

U2 - 10.1017/S0033291707002048

DO - 10.1017/S0033291707002048

M3 - Article

VL - 38

SP - 1133

EP - 1140

JO - Psychological Medicine

T2 - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 8

ER -

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