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Science forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nicholas G D Masca, Elizabeth M A Hensor, Victoria R Cornelius, Francesca M Buffa, Helen M Marriott, James M Eales, Michael P Messenger, Amy E Anderson, Chris Boot, Catey Bunce, Robert D Goldin, Jessica Harris, Rod F Hinchliffe, Hiba Junaid, Shaun Kingston, Carmen Martin-Ruiz, Christopher P Nelson, Janet Peacock, Paul T Seed, Bethany Shinkins & 4 more Karl J Staples, Jamie Toombs, Adam K A Wright, M Dawn Teare

Original languageEnglish
Title of host publicationeLife
Pagese05519
DOIs
Publication statusPublished - 2015

Publication series

NameeLife
Volume4

King's Authors

Abstract

Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, reduce irreproducibility. The framework is intended for using during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.

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