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Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze

Research output: Contribution to journalLiterature review

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Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans : an fMRI study using a virtual reality analogue of the Morris Water Maze. / Antonova, Elena; Parslow, David; Brammer, Michael; Simmons, Andrew; Williams, Steven; Dawson, Gerard R.; Morris, Robin.

In: Journal of Psychopharmacology, Vol. 25, No. 9, N/A, 09.2011, p. 1256-1265.

Research output: Contribution to journalLiterature review

Harvard

Antonova, E, Parslow, D, Brammer, M, Simmons, A, Williams, S, Dawson, GR & Morris, R 2011, 'Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze', Journal of Psychopharmacology, vol. 25, no. 9, N/A, pp. 1256-1265. https://doi.org/10.1177/0269881110379285

APA

Antonova, E., Parslow, D., Brammer, M., Simmons, A., Williams, S., Dawson, G. R., & Morris, R. (2011). Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze. Journal of Psychopharmacology, 25(9), 1256-1265. [N/A]. https://doi.org/10.1177/0269881110379285

Vancouver

Antonova E, Parslow D, Brammer M, Simmons A, Williams S, Dawson GR et al. Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze. Journal of Psychopharmacology. 2011 Sep;25(9):1256-1265. N/A. https://doi.org/10.1177/0269881110379285

Author

Antonova, Elena ; Parslow, David ; Brammer, Michael ; Simmons, Andrew ; Williams, Steven ; Dawson, Gerard R. ; Morris, Robin. / Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans : an fMRI study using a virtual reality analogue of the Morris Water Maze. In: Journal of Psychopharmacology. 2011 ; Vol. 25, No. 9. pp. 1256-1265.

Bibtex Download

@article{3479694d74b34fc5b04ec252e2b65aeb,
title = "Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze",
abstract = "The role of the septohippocampal cholinergic system in memory disorders is well established. The effects of cholinergic challenge in animals have been extensively studied using the Morris Water Maze (MWM) which engages allocentric spatial memory. The present study investigated the effect of the centrally active muscarinic antagonist scopolamine on allocentric spatial memory in humans using a virtual reality analogue of the MWM task, the Arena task. Twenty right-handed healthy male adults with a mean age of 28 years (range 23-35 years) were studied using functional MRI in a randomized double-blind cross-over design with scopolamine bromide (0.4 mg i.m.) or placebo (saline) administered 70-90 min before the beginning of the functional scan. Scopolamine induced a significant reduction in the activation of the hippocampus/parahippocampal gyrus compared with placebo. Furthermore, there was dissociation between hippocampus-based and striatal-based memory systems, which were significantly more activated in the placebo and scopolamine conditions, respectively. The activation of the striatal system under scopolamine challenge was accompanied by the activation of the amygdala. In conclusion, the study extends the well-documented finding in animals of the attenuating effect of scopolamine on hippocampal activity during allocentric spatial memory to humans. Furthermore, the results call for further investigation of the dissociation between the hippocampal and neostriatal memory systems during allocentric spatial processing under cholinergic blockade in humans.",
author = "Elena Antonova and David Parslow and Michael Brammer and Andrew Simmons and Steven Williams and Dawson, {Gerard R.} and Robin Morris",
year = "2011",
month = "9",
doi = "10.1177/0269881110379285",
language = "English",
volume = "25",
pages = "1256--1265",
journal = "Journal of Psychopharmacology",
issn = "0269-8811",
publisher = "SAGE Publications Ltd STM",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans

T2 - an fMRI study using a virtual reality analogue of the Morris Water Maze

AU - Antonova, Elena

AU - Parslow, David

AU - Brammer, Michael

AU - Simmons, Andrew

AU - Williams, Steven

AU - Dawson, Gerard R.

AU - Morris, Robin

PY - 2011/9

Y1 - 2011/9

N2 - The role of the septohippocampal cholinergic system in memory disorders is well established. The effects of cholinergic challenge in animals have been extensively studied using the Morris Water Maze (MWM) which engages allocentric spatial memory. The present study investigated the effect of the centrally active muscarinic antagonist scopolamine on allocentric spatial memory in humans using a virtual reality analogue of the MWM task, the Arena task. Twenty right-handed healthy male adults with a mean age of 28 years (range 23-35 years) were studied using functional MRI in a randomized double-blind cross-over design with scopolamine bromide (0.4 mg i.m.) or placebo (saline) administered 70-90 min before the beginning of the functional scan. Scopolamine induced a significant reduction in the activation of the hippocampus/parahippocampal gyrus compared with placebo. Furthermore, there was dissociation between hippocampus-based and striatal-based memory systems, which were significantly more activated in the placebo and scopolamine conditions, respectively. The activation of the striatal system under scopolamine challenge was accompanied by the activation of the amygdala. In conclusion, the study extends the well-documented finding in animals of the attenuating effect of scopolamine on hippocampal activity during allocentric spatial memory to humans. Furthermore, the results call for further investigation of the dissociation between the hippocampal and neostriatal memory systems during allocentric spatial processing under cholinergic blockade in humans.

AB - The role of the septohippocampal cholinergic system in memory disorders is well established. The effects of cholinergic challenge in animals have been extensively studied using the Morris Water Maze (MWM) which engages allocentric spatial memory. The present study investigated the effect of the centrally active muscarinic antagonist scopolamine on allocentric spatial memory in humans using a virtual reality analogue of the MWM task, the Arena task. Twenty right-handed healthy male adults with a mean age of 28 years (range 23-35 years) were studied using functional MRI in a randomized double-blind cross-over design with scopolamine bromide (0.4 mg i.m.) or placebo (saline) administered 70-90 min before the beginning of the functional scan. Scopolamine induced a significant reduction in the activation of the hippocampus/parahippocampal gyrus compared with placebo. Furthermore, there was dissociation between hippocampus-based and striatal-based memory systems, which were significantly more activated in the placebo and scopolamine conditions, respectively. The activation of the striatal system under scopolamine challenge was accompanied by the activation of the amygdala. In conclusion, the study extends the well-documented finding in animals of the attenuating effect of scopolamine on hippocampal activity during allocentric spatial memory to humans. Furthermore, the results call for further investigation of the dissociation between the hippocampal and neostriatal memory systems during allocentric spatial processing under cholinergic blockade in humans.

U2 - 10.1177/0269881110379285

DO - 10.1177/0269881110379285

M3 - Literature review

VL - 25

SP - 1256

EP - 1265

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 9

M1 - N/A

ER -

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