Scube1 is expressed during facial development in the mouse

Guilherme Xavier; Paul T Sharpe; Martyn T Cobourne

doi:10.1002/jez.b.21260

Scube1 is expressed during facial development in the mouse

Guilherme Xavier, Paul T Sharpe, Martyn T Cobourne

Centre for Craniofacial & Regenerative Biology

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Scube1 encodes a secreted plasma membrane-associated protein characterized by a N-terminal signal peptide sequence, multiple EGF domains, a N-linked glycosylated spacer region and a C-terminal CUB region. Here, we describe expression of the mouse Scube1 gene during early craniofacial development. Transcripts were identified in the nervous system, within the ventral neural tube, telencephalon and trigeminal ganglion. In addition, strong regionally restricted expression was found in the facial processes, including the medial and lateral nasal processes, maxilla and mandible, and caudal pharyngeal arches. During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth. Together, these data suggest a potential role for Scube1 during early craniofacial development.

Original language	English
Pages (from-to)	518-524
Number of pages	7
Journal	JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
Volume	312B
Issue number	5
DOIs	https://doi.org/10.1002/jez.b.21260
Publication status	Published - 15 Jul 2009

Keywords

Animals
Brain
Cell Membrane
Embryonic Development
Face
Gene Expression Regulation, Developmental
In Situ Hybridization
Incisor
Intercellular Signaling Peptides and Proteins
Mandible
Maxilla
Mice
Molar
Neural Tube
RNA, Messenger
Skull

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10.1002/jez.b.21260

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title = "Scube1 is expressed during facial development in the mouse",

abstract = "Scube1 encodes a secreted plasma membrane-associated protein characterized by a N-terminal signal peptide sequence, multiple EGF domains, a N-linked glycosylated spacer region and a C-terminal CUB region. Here, we describe expression of the mouse Scube1 gene during early craniofacial development. Transcripts were identified in the nervous system, within the ventral neural tube, telencephalon and trigeminal ganglion. In addition, strong regionally restricted expression was found in the facial processes, including the medial and lateral nasal processes, maxilla and mandible, and caudal pharyngeal arches. During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth. Together, these data suggest a potential role for Scube1 during early craniofacial development.",

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AU - Sharpe, Paul T

AU - Cobourne, Martyn T

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AB - Scube1 encodes a secreted plasma membrane-associated protein characterized by a N-terminal signal peptide sequence, multiple EGF domains, a N-linked glycosylated spacer region and a C-terminal CUB region. Here, we describe expression of the mouse Scube1 gene during early craniofacial development. Transcripts were identified in the nervous system, within the ventral neural tube, telencephalon and trigeminal ganglion. In addition, strong regionally restricted expression was found in the facial processes, including the medial and lateral nasal processes, maxilla and mandible, and caudal pharyngeal arches. During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth. Together, these data suggest a potential role for Scube1 during early craniofacial development.

KW - Animals

KW - Brain

KW - Cell Membrane

KW - Embryonic Development

KW - Face

KW - Gene Expression Regulation, Developmental

KW - In Situ Hybridization

KW - Incisor

KW - Intercellular Signaling Peptides and Proteins

KW - Mandible

KW - Maxilla

KW - Mice

KW - Molar

KW - Neural Tube

KW - RNA, Messenger

KW - Skull

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DO - 10.1002/jez.b.21260

M3 - Article

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JO - JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

JF - JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

IS - 5

ER -

Scube1 is expressed during facial development in the mouse

Abstract

Keywords

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