King's College London

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Research Outputs

  1. 2018
  2. The fecal metabolome as a functional readout of the gut microbiome

    Zierer, J., Jackson, M. A., Kastenmüller, G., Mangino, M., Long, T., Telenti, A., Mohney, R. P., Small, K. S., Bell, J. T., Steves, C. J., Valdes, A. M., Spector, T. D. & Menni, C. 28 May 2018 In : Nature Genetics. 50, p. 790-795

    Research output: Contribution to journalArticle

  3. Gut microbial diversity is associated with lower arterial stiffness in women

    Menni, C., Lin, C., Cecelja, M., Mangino, M., Matey-Hernandez, M. L., Keehn, L., Mohney, R. P., Steves, C. J., Spector, T. D., Kuo, C-F., Chowienczyk, P. & Valdes, A. M. 9 May 2018 In : European Heart Journal.

    Research output: Contribution to journalArticle

  4. Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

    Visconti, A. , Duffy, D. , Liu, F. , Zhu, G. , Wu, W. , Chen, Y. , Hysi, P. , Zeng, C. , Sanna, M. , Iles, M. M. , Kanetsky, P. A. , Demenais, F. , Hamer, M. A. , Uitterlinden, A. G. , Ikram, M. A. , Nijsten, T. E. C. , Martin, N. G. , Kayser, M. , Spector, T. D. , Han, J. & 2 others Bataille, V. & Falchi, M. 8 May 2018 In : Nature Communications. 1684

    Research output: Contribution to journalArticle

  5. Use of dietary indices to control for diet in human gut microbiota studies

    Bowyer, R. C. E., Jackson, M. A., Pallister, T., Skinner, J., Spector, T. D., Welch, A. A. & Steves, C. J. 25 Apr 2018 In : Microbiome. 6, 1, p. 77

    Research output: Contribution to journalArticle

  6. Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability

    Hysi, P. , Valdes, A. M. , Liu, F. , Furlotte, N. A. , Evans, D. M. , Bataille, V. , Visconti, A. , Hemani, G. , McMahon, G. , Ring, S. M. , Smith, G. D. , Duffy, D. L. , Zhu, G. , Gordon, S. D. , Medland, S. E. , Danae Lin, B. , Willemsen, G. , Hottenga, J-J. , Vuckovic, D. , Girotto, G. & 23 others Gandin, I., Sala, C., Brumat, M., Gasparini, P., Daniela, T., Cocca, M., Robino, A., Yazar, S., Hewitt, A. W., Chen, Y., Zeng, C., Uitterlinden, A. G., Ikram, M. A., Hamer, M. A., van Duijn, C. M., Nijsten, T. E. C., Mackey, D. A., Falchi, M., Boomsma, D. I., Martin, N. G., Hinds, D. A., Kayser, M. & Spector, T. D. 16 Apr 2018 In : Nature Genetics.

    Research output: Contribution to journalLetter

  7. Definitive zygosity scores in the peas in the pod questionnaire is a sensitive and accurate assessment of the zygosity of adult twins

    Jarrar, Z. A., Ward, K. J., Mangino, M., Cherkas, L. F., Gill, R., Gillham-Nasenya, I., Yarand, D., Hart, D., Hammond, C. J. & Spector, T. D. Apr 2018 In : TWIN RESEARCH AND HUMAN GENETICS. 21, 2, p. 146-154

    Research output: Contribution to journalArticle

  8. Metabolomic pathways to osteoporosis in middle-aged women: a genome-metabolome-wide Mendelian randomization study

    Moayyeri, A., Cheung, C-L., Tan, K. C., Morris, J. A., Cerani, A., Mohney, R. P., Richard, J. B., Hammond, C., Spector, T. D. & Menni, C. Apr 2018 In : Journal of Bone and Mineral Research. 33, 4, p. 643-650

    Research output: Contribution to journalArticle

  9. Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated with Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts

    Menni, C., Gudelj, I., MacDonald-Dunlop, E., Mangino, M., Zierer, J., Bešić, E., Joshi, P., Trbojević-Akmačić, I., Chowienczyk, P. J., Spector, T. D., Wilson, J. F., Lauc, G. & Valdes, A. M. 16 Mar 2018 In : Circulation Research.

    Research output: Contribution to journalArticle

  10. Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

    Mullaney, J. A., Stephens, J. E., Costello, M. E., Fong, C., Geeling, B. E., Gavin, P. G., Wright, C. M., Spector, T. D., Brown, M. A. & Hamilton-Williams, E. E. 17 Feb 2018 In : Microbiome. 6, 1, 35

    Research output: Contribution to journalArticle

  11. Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

    Cohen, I. V., Cirulli, E. T., Mitchell, M. W., Jonsson, T. J., Yu, J., Shah, N., Spector, T. D., Guo, L., Venter, J. C. & Telenti, A. 15 Feb 2018 In : EBioMedicine.

    Research output: Contribution to journalArticle

  12. Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

    Viñuela, A., Brown, A. A., Buil, A., Tsai, P-C., Davies, M. N., Bell, J. T., Dermitzakis, E. T., Spector, T. D. & Small, K. S. 15 Feb 2018 In : Human Molecular Genetics. 27, 4, p. 732–741

    Research output: Contribution to journalArticle

  13. Detection of stable community structures within gut microbiota co-occurrence networks from different human populations

    Jackson, M. A., Bonder, M. J., Kuncheva, Z., Zierer, J., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., Bell, J. T., Spector, T. D. & Steves, C. J. 7 Feb 2018 In : PeerJ. 6, p. e4303

    Research output: Contribution to journalArticle

  14. Genetic and microbiome influence on lipid metabolism and dyslipidemia

    Matey-Hernandez, M. L., Williams, F. M. K., Potter, T., Valdes, A. M., Spector, T. D. & Menni, C. 1 Feb 2018 In : PHYSIOLOGICAL GENOMICS. 50, 2, p. 117-126 10 p.

    Research output: Contribution to journalArticle

  15. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

    Jiang, X. , O'Reilly, P. F. , Aschard, H. , Hsu, Y. H. , Richards, J. B. , Dupuis, J. , Ingelsson, E. , Karasik, D. , Pilz, S. , Berry, D. I. , Kestenbaum, B. , Zheng, J. , Luan, J. , Sofianopoulou, E. , Streeten, E. A. , Albanes, D. , Lutsey, P. L. , Yao, L. , Tang, W. , Econs, M. J. & 30 others Wallaschofski, H., Völzke, H., Zhou, A., Power, C., McCarthy, M. I., Michos, E. D., Boerwinkle, E., Weinstein, S. J., Freedman, N. D., Huang, W. Y., Van Schoor, N. M., Van Der Velde, N., Groot, L. C. P. G. M. D., Enneman, A., Cupples, L. A., Booth, S. L., Vasan, R. S., Liu, C. T., Zhou, Y., Ripatti, S., Ohlsson, C., Vandenput, L., Lorentzon, M., Eriksson, J. G., Shea, M. K., Houston, D. K., Kritchevsky, S. B., Liu, Y., Valdes, A. M. & Spector, T. 17 Jan 2018 In : Nature Communications. 9, 1, 260

    Research output: Contribution to journalArticle

  16. Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

    Zaghlool, S. B. , Mook-Kanamori, D. O. , Kader, S. , Stephan, N. , Halama, A. , Engelke, R. , Sarwath, H. , Al-Dous, E. K. , Mohamoud, Y. A. , Roemisch-Margl, W. , Adamski, J. , Kastenmüller, G. , Friedrich, N. , Visconti, A. , Tsai, P-C. , Spector, T. , Bell, J. , Falchi, M. , Wahl, A. , Waldenberger, M. & 7 others Peters, A., Gieger, C., Pezer, M., Lauc, G., Graumann, J., Malek, J. A. & Suhre, K. 8 Jan 2018 In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  17. Ensemble landmarking of 3D facial surface scans

    de Jong, M. A., Hysi, P., Spector, T., Niessen, W., Koudstaal, M. J., Wolvius, E. B., Kayser, M. & Böhringer, S. 8 Jan 2018 In : Scientific Reports. 8, 1, p. 12

    Research output: Contribution to journalArticle

  18. Meta-analysis of epigenome-wide association studies of cognitive abilities

    Marioni, R. E. , McRae, A. F. , Bressler, J. , Colicino, E. , Hannon, E. , Li, S. , Prada, D. , Smith, J. A. , Trevisi, L. , Tsai, P-C. , Vojinovic, D. , Simino, J. , Levy, D. , Liu, C. , Mendelson, M. , Satizabal, C. L. , Yang, Q. , Jhun, M. A. , Kardia, S. L. R. , Zhao, W. & 27 others Bandinelli, S., Ferrucci, L., Hernandez, D. G., Singleton, A. B., Harris, S. E., Starr, J. M., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y-H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I. J. 8 Jan 2018 In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  19. Genetics of the human face: Identification of large-effect single gene variants

    Crouch, D. J. M., Winney, B., Koppen, W. P., Christmas, W. J., Hutnik, K., Day, T., Meena, D., Boumertit, A., Hysi, P., Nessa, A., Spector, T. D., Kittler, J. & Bodmer, W. F. 4 Jan 2018 In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  20. Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

    Medina-Gomez, C. , Kemp, J. P. , Trajanoska, K. , Luan, J. , Chesi, A. , Ahluwalia, T. S. , Mook-Kanamori, D. O. , Ham, A. , Hartwig, F. P. , Evans, D. S. , Joro, R. , Nedeljkovic, I. , Zheng, H-F. , Zhu, K. , Atalay, M. , Liu, C-T. , Nethander, M. , Broer, L. , Porleifsson, G. , Mullin, B. H. & 69 others Handelman, S. K., Nalls, M. A., Jessen, L. E., Heppe, D. H. M., Richards, J. B., Wang, C., Chawes, B., Schraut, K. E., Amin, N., Wareham, N., Karasik, D., Van der Velde, N., Ikram, M. A., Zemel, B. S., Zhou, Y., Carlsson, C. J., Liu, Y., McGuigan, F. E., Boer, C. G., Bønnelykke, K., Ralston, S. H., Robbins, J. A., Walsh, J. P., Zillikens, M. C., Langenberg, C., Li-Gao, R., Williams, F. M. K., Harris, T. B., Akesson, K., Jackson, R. D., Sigurdsson, G., den Heijer, M., van der Eerden, B. C. J., van de Peppel, J., Spector, T. D., Pennell, C., Horta, B. L., Felix, J. F., Zhao, J. H., Wilson, S. G., de Mutsert, R., Bisgaard, H., Styrkársdóttir, U., Jaddoe, V. W., Orwoll, E., Lakka, T. A., Scott, R., Grant, S. F. A., Lorentzon, M., van Duijn, C. M., Wilson, J. F., Stefansson, K., Psaty, B. M., Kiel, D. P., Ohlsson, C., Ntzani, E., van Wijnen, A. J., Forgetta, V., Ghanbari, M., Logan, J. G., Williams, G. R., Bassett, J. H. D., Croucher, P. I., Evangelou, E., Uitterlinden, A. G., Ackert-Bicknell, C. L., Tobias, J. H., Evans, D. M. & Rivadeneira, F. 4 Jan 2018 In : American Journal of Human Genetics. 102, 1, p. 88-102 15 p.

    Research output: Contribution to journalArticle

  21. Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

    Beaumont, R. N. , Warrington, N. M. , Cavadino, A. , Tyrrell, J. , Nodzenski, M. , Horikoshi, M. , Geller, F. , Myhre, R. , Richmond, R. C. , Paternoster, L. , Bradfield, J. P. , Kreiner-Møller, E. , Huikari, V. , Metrustry, S. , Lunetta, K. L. , Painter, J. N. , Hottenga, J-J. , Allard, C. , Barton, S. J. , Espinosa, A. & 31 others Marsh, J. A., Potter, C., Zhang, G., Ang, W., Berry, D. J., Bouchard, L., Das, S., Hakonarson, H., Heikkinen, J., Helgeland, Ø., Hocher, B., Hofman, A., Inskip, H. M., Jones, S. E., Kogevinas, M., Lind, P. A., Marullo, L., Medland, S. E., Murray, A., Murray, J. C., Njølstad, P. R., Nohr, E. A., Reichetzeder, C., Ring, S. M., Ruth, K. S., Santa-Marina, L., Scholtens, D. M., Sebert, S., Sengpiel, V., Spector, T. D. & Early Growth Genetics (EGG) Consortium 3 Jan 2018 In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  22. Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

    Bell, C. G., Gao, F., Yuan, W., Roos, L., Acton, R. J., Xia, Y., Bell, J., Ward, K., Mangino, M., Hysi, P. G., Wang, J. & Spector, T. D. 2 Jan 2018 In : Nature communications. 9, 1, 13 p., 8

    Research output: Contribution to journalArticle

  23. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Turcot, V. , Lu, Y. , Highland, H. M. , Schurmann, C. , Justice, A. E. , Fine, R. S. , Bradfield, J. P. , Esko, T. , Giri, A. , Graff, M. , Guo, X. , Hendricks, A. E. , Karaderi, T. , Lempradl, A. , Locke, A. E. , Mahajan, A. , Marouli, E. , Sivapalaratnam, S. , Young, K. L. , Alfred, T. & 31 others Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Breen, G., Small, K. S., Spector, T. D. & CHD Exome+ Consortium Jan 2018 In : Nature Genetics. 50, 1, p. 26-41 16 p.

    Research output: Contribution to journalArticle

  24. Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress

    Metrustry, S. J., Karhunen, V., Edwards, M. H., Menni, C., Geisendorfer, T., Huber, A., Reichel, C., Dennison, E. M., Cooper, C., Spector, T., Jarvelin, M-R. & Valdes, A. M. 2018 In : PloS one. 13, 3, p. e0194316

    Research output: Contribution to journalArticle

  25. 2017
  26. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

    Jason, F. , Fuchsberger, C. , Mahajan, A. , Teslovich, T. M. , Agarwala, V. , Gaulton, K. J. , Caulkins, L. , Koesterer, R. , Ma, C. , Moutsianas, L. , McCarthy, D. J. , Rivas, M. A. , Perry, J. R. B. , Sim, X. , Blackwell, T. W. , Robertson, N. R. , Rayner, N. W. , Cingolani, P. , Locke, A. E. , Tajes, J. F. & 281 others Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., van de Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B-J., Kim, Y., Kim, Y. J., Kwon, M-S., Lee, J., Lee, S., Lin, K-H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B-G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S-H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C-Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C-C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S-T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., de Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A-C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J-Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E. S., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I. 19 Dec 2017 In : Scientific Data. 4, p. 170179

    Research output: Contribution to journalArticle

  27. Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair

    Liu, F. , Chen, Y. , Zhu, G. , Hysi, P. G. , Wu, S. , Adhikari, K. , Breslin, K. , Pospiech, E. , Hamer, M. A. , Peng, F. , Muralidharan, C. , Acuna-Alonzo, V. , Canizales-Quinteros, S. , Bedoya, G. , Gallo, C. , Poletti, G. , Rothhammer, F. , Bortolini, M. C. , Gonzalez-Jose, R. , Zeng, C. & 14 others Xu, S., Jin, L., Uitterlinden, A. G., Ikram, M. A., van Duijn, C. M., Nijsten, T., Walsh, S., Branicki, W., Wang, S., Ruiz-Linares, A., Spector, T. D., Martin, N. G., Medland, S. E. & Kayser, M. 6 Dec 2017 In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  28. Association of the resolvin precursor 17-HDHA, but not D-or E-series resolvins, with heat pain sensitivity and osteoarthritis pain in humans

    Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., Nessa, A., Williams, F. M. K., Spector, T. D., Doherty, M., Chapman, V. & Barrett, D. A. 1 Dec 2017 In : Scientific Reports. 7, 1, 10748

    Research output: Contribution to journalArticle

  29. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

    Macé, A. , Tuke, M. A. , Deelen, P. , Kristiansson, K. , Mattsson, H. , Nõukas, M. , Sapkota, Y. , Schick, U. , Porcu, E. , Rüeger, S. , McDaid, A. F. , Porteous, D. , Winkler, T. W. , Salvi, E. , Shrine, N. , Liu, X. , Ang, W. Q. , Zhang, W. , Feitosa, M. F. , Venturini, C. & 86 others Van Der Most, P. J., Rosengren, A., Wood, A. R., Beaumont, R. N., Jones, S. E., Ruth, K. S., Yaghootkar, H., Tyrrell, J., Havulinna, A. S., Boers, H., Mägi, R., Kriebel, J., Müller-Nurasyid, M., Perola, M., Nieminen, M., Lokki, M. L., Kähönen, M., Viikari, J. S., Geller, F., Lahti, J., Palotie, A., Koponen, P., Lundqvist, A., Rissanen, H., Bottinger, E. P., Afaq, S., Wojczynski, M. K., Lenzini, P., Nolte, I. M., Sparsø, T., Schupf, N., Christensen, K., Perls, T. T., Newman, A. B., Werge, T., Snieder, H., Spector, T. D., Chambers, J. C., Koskinen, S., Melbye, M., Raitakari, O. T., Lehtimäki, T., Tobin, M. D., Wain, L. V., Sinisalo, J., Peters, A., Meitinger, T., Martin, N. G., Wray, N. R., Montgomery, G. W., Medland, S. E., Swertz, M. A., Vartiainen, E., Borodulin, K., Männistö, S., Murray, A., Bochud, M., Jacquemont, S., Rivadeneira, F., Hansen, T. F., Oldehinkel, A. J., Mangino, M., Province, M. A., Deloukas, P., Kooner, J. S., Freathy, R. M., Pennell, C., Feenstra, B., Strachan, D. P., Lettre, G., Hirschhorn, J., Cusi, D., Heid, I. M., Hayward, C., Männik, K., Beckmann, J. S., Loos, R. J. F., Nyholt, D. R., Metspalu, A., Eriksson, J. G., Weedon, M. N., Salomaa, V., Franke, L., Reymond, A., Frayling, T. M. & Kutalik, Z. 1 Dec 2017 In : Nature Communications. 8, 1, 744

    Research output: Contribution to journalArticle

  30. Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

    Lukowski, S. W., Lloyd-Jones, L. R., Holloway, A., Kirsten, H., Hemani, G., Yang, J., Small, K., Zhao, J., Metspalu, A., Dermitzakis, E. T., Gibson, G., Spector, T. D., Thiery, J., Scholz, M., Montgomery, G. W., Esko, T., Visscher, P. M. & Powell, J. E. 1 Dec 2017 In : Nature Communications. 8, 1, 483

    Research output: Contribution to journalArticle

  31. Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome

    Pallister, T., Jackson, M. A., Martin, T. C., Zierer, J., Jennings, A., Mohney, R. P., MacGregor, A., Steves, C. J., Cassidy, A., Spector, T. D. & Menni, C. 1 Dec 2017 In : Scientific Reports. 7, 1, 13670

    Research output: Contribution to journalArticle

  32. Exome-wide association study of plasma lipids in >300,000 individuals

    Liu, D. J. , Peloso, G. M. , Yu, H. , Butterworth, A. S. , Wang, X. , Mahajan, A. , Saleheen, D. , Emdin, C. , Alam, D. , Alves, A. C. , Amouyel, P. , Di Angelantonio, E. , Arveiler, D. , Assimes, T. L. , Auer, P. L. , Baber, U. , Ballantyne, C. M. , Bang, L. E. , Benn, M. , Bis, J. C. & 31 others Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M-P., Ebeling, T., Eiriksdottir, G., Esko, T., Small, K. S., Spector, T. D. & Charge Diabetes Working Group Dec 2017 In : Nature Genetics. 49, 12, p. 1758-1766 9 p.

    Research output: Contribution to journalLetter

  33. Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker

    Cole, J. H., Poudel, R. P. K., Tsagkrasoulis, D., Caan, M. W. A., Steves, C., Spector, T. D. & Montana, G. Dec 2017 In : NeuroImage. 163, p. 115-124

    Research output: Contribution to journalArticle

  34. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

    Richard, M. A. , Huan, T. , Ligthart, S. , Gondalia, R. , Jhun, M. A. , Brody, J. A. , Irvin, M. R. , Marioni, R. , Shen, J. , Tsai, P-C. , Montasser, M. E. , Jia, Y. , Syme, C. , Salfati, E. L. , Boerwinkle, E. , Guan, W. , Mosley, T. H. , Bressler, J. , Morrison, A. C. , Liu, C. & 31 others Mendelson, M. M., Uitterlinden, A. G., van Meurs, J. B., Franco, O. H., Zhang, G., Li, Y., Stewart, J. D., Bis, J. C., Psaty, B. M., Chen, Y-D. I., Kardia, S. L. R., Zhao, W., Turner, S. T., Absher, D., Aslibekyan, S., Starr, J. M., McRae, A. F., Hou, L., Just, A. C., Schwartz, J. D., Vokonas, P. S., Menni, C., Spector, T. D., Shuldiner, A., Damcott, C. M., Rotter, J. I., Palmas, W., Liu, Y., Paus, T., Bell, J. T. & BIOS Consortium 30 Nov 2017 In : American Journal of Human Genetics.

    Research output: Contribution to journalArticle

  35. Epigenetic discrimination of identical twins from blood under the forensic scenario

    Vidaki, A., López, C. D., Carnero-Montoro, E., Ralf, A., Ward, K., Spector, T., Bell, J. T. & Kayser, M. Nov 2017 In : Forensic Science International-Genetics. 31, p. 67-80 14 p.

    Research output: Contribution to journalArticle

  36. Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues

    Brown, A. A., Viñuela, A., Delaneau, O., Spector, T. D., Small, K. S. & Dermitzakis, E. T. 23 Oct 2017 In : Nature Genetics. 49, 12, p. 1747-1751

    Research output: Contribution to journalLetter

  37. IgG glycosylation and DNA methylation are interconnected with smoking

    Wahl, A. , Kasela, S. , Monotoro, E. C. , van Iterson, M. , Štambuk, J. , Sharma, S. , van den Akker, E. , Klaric, L. , Benedetti, E. , Razdorov, G. , Trbojević-Akmačić, I. , Vučković, F. , Ugrina, I. , Beekman, M. , Deelen, J. , van Heemst, D. , Heijmans, B. T. , Consortium, B. I. O. S. , Wuhrer, M. , Plomp, R. & 14 others Keser, T., Šimurina, M., Pavić, T., Gudelj, I., Krištić, J., Grallert, H., Kunze, S., Peters, A., Bell, J. T., Spector, T. D., Milani, L., Eline Slagboom, P., Lauc, G. & Gieger, C. 18 Oct 2017 In : BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 1862, 3, p. 637-648

    Research output: Contribution to journalArticle

  38. A Comparison of Heritability Estimates by Classical Twin Modeling and Based on Genome-Wide Genetic Relatedness for Cardiac Conduction Traits

    Nolte, I. M., Jansweijer, J. A., Riese, H., Asselbergs, F. W., van der Harst, P., Spector, T. D., Pinto, Y. M., Snieder, H. & Jamshidi, Y. 17 Oct 2017 In : TWIN RESEARCH AND HUMAN GENETICS. p. 1-10 10 p.

    Research output: Contribution to journalArticle

  39. Differential DNA Methylation in Monozygotic Twins Discordant for Female Sexual Functioning

    Burri, A., Leupin, M., Spector, T. & Marinova, Z. 28 Sep 2017 In : JOURNAL OF SEXUAL MEDICINE. 14, 11, p. 1357-1364

    Research output: Contribution to journalArticle

  40. Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

    Shen, X., Klarić, L., Sharapov, S., Mangino, M., Ning, Z., Wu, D., Trbojević-Akmačić, I., Pučić-Baković, M., Rudan, I., Polašek, O., Hayward, C., Spector, T. D., Wilson, J. F., Lauc, G. & Aulchenko, Y. S. 6 Sep 2017 In : Nature Communications. 8, 1, 447

    Research output: Contribution to journalArticle

  41. Genome-Wide Association Reveals Pigmentation Genes Play a Role in Skin Aging

    Law, M. H. , Medland, S. E. , Zhu, G. , Yazar, S. , Viñuela, A. , Wallace, L. , Shekar, S. N. , Duffy, D. L. , Bataille, V. , Glass, D. , Spector, T. D. , Wood, D. , Gordon, S. D. , Barbour, J. M. , Henders, A. K. , Hewitt, A. W. , Montgomery, G. W. , Sturm, R. A. , Mackey, D. A. , Green, A. C. & 2 others Martin, N. G. & MacGregor, S. Sep 2017 In : Journal of Investigative Dermatology. 137, 9, p. 1887-1894

    Research output: Contribution to journalArticle

  42. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

    Wheeler, E. , Leong, A. , Liu, C-T. , Hivert, M-F. , Strawbridge, R. J. , Podmore, C. , Li, M. , Yao, J. , Sim, X. , Hong, J. , Chu, A. Y. , Zhang, W. , Wang, X. , Chen, P. , Maruthur, N. M. , Porneala, B. C. , Sharp, S. J. , Jia, Y. , Kabagambe, E. K. , Chang, L-C. & 31 others Chen, W-M., Elks, C. E., Evans, D. S., Fan, Q., Giulianini, F., Go, M. J., Hottenga, J-J., Hu, Y., Jackson, A. U., Kanoni, S., Kim, Y. J., Kleber, M. E., Ladenvall, C., Lecoeur, C., Lim, S-H., Lu, Y., Mahajan, A., Marzi, C., Nalls, M. A., Navarro, P., Nolte, I. M., Rose, L. M., Rybin, D. V., Sanna, S., Shi, Y., Stram, D. O., Takeuchi, F., Tan, S. P., van der Most, P. J., Spector, T. D. & EPIC-CVD Consortium Sep 2017 In : PL o S Medicine. 14, 9, p. e1002383

    Research output: Contribution to journalArticle

  43. Genetic and environmental influences on stability and change in baseline levels of C-reactive protein: A longitudinal twin study

    Sas, A. A., Vaez, A., Jamshidi, Y., Nolte, I. M., Kamali, Z., Spector, T. D., Riese, H. & Snieder, H. 31 Aug 2017 In : Atherosclerosis.

    Research output: Contribution to journalArticle

  44. Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

    Hollander, W. D. , Boer, C. G. , Hart, D. J. , Yau, M. S. , Ramos, Y. F. M. , Metrustry, S. , Broer, L. , Deelen, J. , Cupples, L. A. , Rivadeneira, F. , Kloppenburg, M. , Peters, M. , Spector, T. D. , Hofman, A. , Slagboom, P. E. , Nelissen, R. G. H. H. , Uitterlinden, A. G. , Felson, D. T. , Valdes, A. M. , Meulenbelt, I. & 1 others van Meurs, J. J. B. 30 Aug 2017 In : Annals of the rheumatic diseases. 76, 12, p. 2046-2053

    Research output: Contribution to journalArticle

  45. Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: An individual-based pooled analysis of 40 twin cohorts

    Silventoinen, K. , Jelenkovic, A. , Sund, R. , Yokoyama, Y. , Hur, Y. M. , Cozen, W. , Hwang, A. E. , Mack, T. M. , Honda, C. , Inui, F. , Iwatani, Y. , Watanabe, M. , Tomizawa, R. , Pietilainen, K. H. , Rissanen, A. , Siribaddana, S. H. , Hotopf, M. , Sumathipala, A. , Rijsdijk, F. , Tan, Q. & 82 others Zhang, D., Pang, Z., Piirtola, M., Aaltonen, S., Oncel, S. Y., Aliev, F., Rebato, E., Hjelmborg, J. B., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Cutler, T. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Song, Y. M., Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. U., Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Spector, T. D., Mangino, M., Lachance, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Huibregtse, B. M., Bartels, M., Van Beijsterveldt, C. E. M., Willemsen, G., Goldberg, J. H., Rasmussen, F., Tarnoki, A. D., Tarnoki, D. L., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Hopper, J. L., Sung, J., Maes, H. H., Turkheimer, E., Boomsma, D. I., Sørensen, T. I. A. & Kaprio, J. 1 Aug 2017 In : American Journal of Clinical Nutrition. 106, 2, p. 457-466 10 p.

    Research output: Contribution to journalArticle

  46. Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS

    Rosenberger, G., Liu, Y., Röst, H. L., Ludwig, C., Buil, A., Bensimon, A., Soste, M., Spector, T. D., Dermitzakis, E. T., Collins, B. C., Malmström, L. & Aebersold, R. 1 Aug 2017 In : Nature Biotechnology. 35, 8, p. 781-788 8 p.

    Research output: Contribution to journalArticle

  47. Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene

    Warner, S. C., Walsh, D. A., Laslett, L. L., Maciewicz, R. A., Soni, A., Hart, D. J., Zhang, W., Muir, K. R., Dennison, E. M., Leaverton, P., Rampersaud, E., Cooper, C., Spector, T. D., Cicuttini, F. M., Arden, N. K., Jones, G., Doherty, M. & Valdes, A. M. Aug 2017 In : European journal of pain (London, England). p. 1277-1284

    Research output: Contribution to journalArticle

  48. Metabolomic Profiling of Long-Term Weight Change: Role of Oxidative Stress and Urate Levels in Weight Gain

    Menni, C., Migaud, M., Kastenmüller, G., Pallister, T., Zierer, J., Peters, A., Mohney, R. P., Spector, T. D., Bagnardi, V., Gieger, C., Moore, S. C. & Valdes, A. M. 31 Jul 2017 In : Obesity. 25, 9, p. 1618-1624

    Research output: Contribution to journalArticle

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