King's College London

Research portal

Research Outputs

  1. 2019
  2. Ascorbic acid metabolites are involved in intraocular pressure control in the general population

    Hysi, P. G., Khawaja, A. P., Menni, C., Tamraz, B., Wareham, N., Khaw, K-T., Foster, P. J., Benet, L. Z., Spector, T. D. & Hammond, C. J. Jan 2019 In : Redox Biology. 20, p. 349-353

    Research output: Contribution to journalArticle

  3. 2018
  4. Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

    Bell, C. G., Gao, F., Yuan, W., Roos, L., Acton, R. J., Xia, Y., Bell, J., Ward, K., Mangino, M., Hysi, P. G., Wang, J. & Spector, T. D. 1 Dec 2018 In : Nature communications. 9, 1, 13 p., 8

    Research output: Contribution to journalArticle

  5. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

    CHARGE Inflammation Working Group, LifeLines Cohort Study, Rose, L. M. , Wu, Y. , Lin, H. , Macé, A. , Abbasi, A. , Smith, A. V. , Mueller, C. , Zhao, J. H. , Amini, M. , Wilson, J. F. , Jamshidi, Y. , Uher, R. , Hicks, A. , Morris, A. P. , Stacey, D. , Eriksson, J. , Chen, W-M. , Li, X. & 39 others Cheng, Y-C., Zhao, J. H., Huang, H., Liu, Y., Huang, J., Joshi, P. K., Lehne, B., Stott, D. J., Menni, C., Peters, A., Smit, J. H., Williams, S. R., Campbell, H., Chen, Y-DI., James, A. L., Smith, E. N., Larsson, A., Wang, Y., Scott, W. R., Evans, D. M., Madden, P. A. F., Lachance, G., Clarke, R., Harris, T. B., Scott, R. A., Hicks, A., Li, J. Z., Chambers, J. C., Martin, N. G., Scott, R. A., Whitfield, J. B., Spector, T. D., Eriksson, J., Wilson, J. F., Palmer, L. J., Murray, S. S., Evans, D. M., Schmidt, H. & Smith, G. D. 1 Nov 2018 In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

    Research output: Contribution to journalArticle

  6. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

    LifeLines Cohort Study 26 Oct 2018 In : Nature Communications. 9, 1, p. 4455

    Research output: Contribution to journalArticle

  7. Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 06 Biological Sciences 0604 Genetics

    Tsai, P. C. , Glastonbury, C. A. , Eliot, M. N. , Bollepalli, S. , Yet, I. , Castillo-Fernandez, J. E. , Carnero-Montoro, E. , Hardiman, T. , Martin, T. C. , Vickers, A. , Mangino, M. , Ward, K. , Pietiläinen, K. H. , Deloukas, P. , Spector, T. D. , Viñuela, A. , Loucks, E. B. , Ollikainen, M. , Kelsey, K. T. , Small, K. S. & 1 others Bell, J. T. 20 Oct 2018 In : Clinical Epigenetics. 10, 1, 126

    Research output: Contribution to journalArticle

  8. Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

    Cirulli, E. T., Guo, L., Leon Swisher, C., Shah, N., Huang, L., Napier, L. A., Kirkness, E. F., Spector, T. D., Caskey, C. T., Thorens, B., Venter, J. C. & Telenti, A. 11 Oct 2018 In : CELL METABOLISM.

    Research output: Contribution to journalArticle

  9. Genome-wide methylation analysis identifies ELOVL5 as an epigenetic biomarker for the risk of type 2 diabetes mellitus

    Hwang, J-Y., Lee, H. J., Go, M. J., Jang, H. B., Choi, N-H., Bae, J. B., Castillo-Fernandez, J. E., Bell, J. T., Spector, T. D., Lee, H-J. & Kim, B-J. 5 Oct 2018 In : Scientific Reports. 8, 1, p. 14862

    Research output: Contribution to journalArticle

  10. The narrow-sense and common single nucleotide polymorphism heritability of early repolarization

    Bastiaenen, R., Nolte, I. M., Munroe, P. B., Riese, H., Nelson, C., O'Connor, H., Gang, Y., Warren, H. R., Cabrera, C., Reinhard, W., Hengstenberg, C., Rijsdijk, F. V., Spector, T., Snieder, H., Samani, N. J., Jamshidi, Y. & Behr, E. R. 4 Oct 2018 In : International Journal of Cardiology.

    Research output: Contribution to journalArticle

  11. Relation of arterial stiffness to left ventricular structure and function in healthy women

    Zhang, J., Chowienczyk, P. J., Spector, T. D. & Jiang, B. 25 Sep 2018 In : Cardiovascular ultrasound. 16, 1, 7 p.

    Research output: Contribution to journalArticle

  12. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

    Million Veteran Program 17 Sep 2018 In : Nature Genetics. 50, 10, p. 1412-1425 14 p.

    Research output: Contribution to journalArticle

  13. A metagenome-wide association study of gut microbiota in asthma in UK adults

    Wang, Q., Li, F., Liang, B., Liang, Y., Chen, S., Mo, X., Ju, Y., Zhao, H., Jia, H., Spector, T. D., Xie, H. & Guo, R. 12 Sep 2018 In : BMC Microbiology. 18, 1, p. 114

    Research output: Contribution to journalArticle

  14. Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins

    Amin, V., Dunn, P. & Spector, T. Sep 2018 In : Economics and human biology. 31, p. 200-208 9 p.

    Research output: Contribution to journalArticle

  15. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

    23andMe Research Team, Pasman, J. A. , Verweij, K. J. H. , Gerring, Z. , Stringer, S. , Sanchez-Roige, S. , Treur, J. L. , Abdellaoui, A. , Nivard, M. G. , Baselmans, B. M. L. , Ong, J-S. , Ip, H. F. , van der Zee, M. D. , Bartels, M. , Day, F. R. , Fontanillas, P. , Elson, S. L. , de Wit, H. , Davis, L. K. , MacKillop, J. & 29 others Derringer, J. L., Branje, S. J. T., Hartman, C. A., Heath, A. C., van Lier, P. A. C., Madden, P. A. F., Mägi, R., Meeus, W., Montgomery, G. W., Oldehinkel, A. J., Pausova, Z., Ramos-Quiroga, J. A., Paus, T., Ribases, M., Kaprio, J., Boks, M. P. M., Bell, J. T., Spector, T. D., Gelernter, J., Boomsma, D. I., Martin, N. G., MacGregor, S., Perry, J. R. B., Palmer, A. A., Posthuma, D., Munafò, M. R., Gillespie, N. A., Derks, E. M. & Vink, J. M. Sep 2018 In : Nature Neuroscience. 21, 9, p. 1161-1170 10 p.

    Research output: Contribution to journalArticle

  16. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

    van Setten, J. , Brody, J. A. , Jamshidi, Y. , Swenson, B. R. , Butler, A. M. , Campbell, H. , Del Greco, F. M. , Evans, D. S. , Gibson, Q. , Gudbjartsson, D. F. , Kerr, K. F. , Krijthe, B. P. , Lyytikäinen, L-P. , Müller, C. , Müller-Nurasyid, M. , Nolte, I. M. , Padmanabhan, S. , Ritchie, M. D. , Robino, A. , Smith, A. V. & 106 others Steri, M., Tanaka, T., Teumer, A., Trompet, S., Ulivi, S., Verweij, N., Yin, X., Arnar, D. O., Asselbergs, F. W., Bader, J. S., Barnard, J., Bis, J., Blankenberg, S., Boerwinkle, E., Bradford, Y., Buckley, B. M., Chung, M. K., Crawford, D., den Hoed, M., Denny, J. C., Dominiczak, A. F., Ehret, G. B., Eijgelsheim, M., Ellinor, P. T., Felix, S. B., Franco, O. H., Franke, L., Harris, T. B., Holm, H., Ilaria, G., Iorio, A., Kähönen, M., Kolcic, I., Kors, J. A., Lakatta, E. G., Launer, L. J., Lin, H., Lin, H. J., Loos, R. J. F., Lubitz, S. A., Macfarlane, P. W., Magnani, J. W., Leach, I. M., Meitinger, T., Mitchell, B. D., Munzel, T., Papanicolaou, G. J., Peters, A., Pfeufer, A., Pramstaller, P. P., Raitakari, O. T., Rotter, J. I., Rudan, I., Samani, N. J., Schlessinger, D., Silva Aldana, C. T., Sinner, M. F., Smith, J. D., Snieder, H., Soliman, E. Z., Spector, T. D., Stott, D. J., Strauch, K., Tarasov, K. V., Thorsteinsdottir, U., Uitterlinden, A. G., Van Wagoner, D. R., Völker, U., Völzke, H., Waldenberger, M., Jan Westra, H., Wild, P. S., Zeller, T., Alonso, A., Avery, C. L., Bandinelli, S., Benjamin, E. J., Cucca, F., Dörr, M., Ferrucci, L., Gasparini, P., Gudnason, V., Hayward, C., Heckbert, S. R., Hicks, A. A., Jukema, J. W., Kääb, S., Lehtimäki, T., Liu, Y., Munroe, P. B., Parsa, A., Polasek, O., Psaty, B. M., Roden, D. M., Schnabel, R. B., Sinagra, G., Stefansson, K., Stricker, B. H., van der Harst, P., van Duijn, C. M., Wilson, J. F., Gharib, S. A., de Bakker, P. I. W., Isaacs, A., Arking, D. E. & Sotoodehnia, N. 25 Jul 2018 In : Nature Communications. 9, 1, p. 2904

    Research output: Contribution to journalArticle

  17. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

    Prins, B. P. , Mead, T. J. , Brody, J. A. , Sveinbjornsson, G. , Ntalla, I. , Bihlmeyer, N. A. , van den Berg, M. , Bork-Jensen, J. , Cappellani, S. , Van Duijvenboden, S. , Klena, N. T. , Gabriel, G. C. , Liu, X. , Gulec, C. , Grarup, N. , Haessler, J. , Hall, L. M. , Iorio, A. , Isaacs, A. , Li-Gao, R. & 93 others Lin, H., Liu, C-T., Lyytikäinen, L-P., Marten, J., Mei, H., Müller-Nurasyid, M., Orini, M., Padmanabhan, S., Radmanesh, F., Ramirez, J., Robino, A., Schwartz, M., van Setten, J., Smith, A. V., Verweij, N., Warren, H. R., Weiss, S., Alonso, A., Arnar, D. O., Bots, M. L., de Boer, R. A., Dominiczak, A. F., Eijgelsheim, M., Ellinor, P. T., Guo, X., Felix, S. B., Harris, T. B., Hayward, C., Heckbert, S. R., Huang, P. L., Jukema, J. W., Kähönen, M., Kors, J. A., Lambiase, P. D., Launer, L. J., Li, M., Linneberg, A., Nelson, C. P., Pedersen, O., Perez, M., Peters, A., Polasek, O., Psaty, B. M., Raitakari, O. T., Rice, K. M., Rotter, J. I., Sinner, M. F., Soliman, E. Z., Spector, T. D., Strauch, K., Thorsteinsdottir, U., Tinker, A., Trompet, S., Uitterlinden, A., Vaartjes, I., van der Meer, P., Völker, U., Völzke, H., Waldenberger, M., Wilson, J. G., Xie, Z., Asselbergs, F. W., Dörr, M., van Duijn, C. M., Gasparini, P., Gudbjartsson, D. F., Gudnason, V., Hansen, T., Kääb, S., Kanters, J. K., Kooperberg, C., Lehtimäki, T., Lin, H. J., Lubitz, S. A., Mook-Kanamori, D. O., Conti, F. J., Newton-Cheh, C. H., Rosand, J., Rudan, I., Samani, N. J., Sinagra, G., Smith, B. H., Holm, H., Stricker, B. H., Ulivi, S., Sotoodehnia, N., Apte, S. S., van der Harst, P., Stefansson, K., Munroe, P. B., Arking, D. E., Lo, C. W. & Jamshidi, Y. 17 Jul 2018 In : Genome Biology. 19, 1, p. 87

    Research output: Contribution to journalArticle

  18. Molecular genetic overlap between migraine and major depressive disorder

    The International Headache Genetics Consortium & Spector, T. D. 11 Jul 2018 In : European Journal of Human Genetics. 26, 8, p. 1202-1216 15 p.

    Research output: Contribution to journalArticle

  19. Role of the gut microbiota in nutrition and health

    Valdes, A. M., Walter, J., Segal, E. & Spector, T. D. 13 Jun 2018 In : BMJ (Online). 361, p. k2179

    Research output: Contribution to journalArticle

  20. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

    MiBioGen Consortium Initiative 8 Jun 2018 In : Microbiome. 6, 1, p. 101

    Research output: Contribution to journalArticle

  21. Genome-wide association study identifies nine novel loci for 2D:4D finger ratio: a putative retrospective biomarker of testosterone exposure in utero

    Warrington, N. M. , Shevroja, E. , Hemani, G. , Hysi, P. G. , Jiang, Y. , Auton, A. , Boer, C. G. , Mangino, M. , Wang, C. A. , Kemp, J. P. , McMahon, G. , Medina-Gomez, C. , Hickey, M. , Trajanoska, K. , Wolke, D. , Ikram, A. M. , 23 and Me Research Team, Montgomery, G. W. , Felix, J. F. , Wright, M. J. & 11 others Mackey, D. A., Jaddoe, V. W., Martin, N. G., Tung, J. Y., Davey Smith, G., Pennell, C. E., Spector, T. D., van Meurs, J., Rivadeneira, F., Medland, S. E. & Evans, D. M. 1 Jun 2018 In : Human Molecular Genetics. p. 2025–2038

    Research output: Contribution to journalArticle

  22. The fecal metabolome as a functional readout of the gut microbiome

    Zierer, J., Jackson, M. A., Kastenmüller, G., Mangino, M., Long, T., Telenti, A., Mohney, R. P., Small, K. S., Bell, J. T., Steves, C. J., Valdes, A. M., Spector, T. D. & Menni, C. 28 May 2018 In : Nature Genetics. 50, p. 790-795

    Research output: Contribution to journalArticle

  23. American Gut: an Open Platform for Citizen Science Microbiome Research

    McDonald, D. , Hyde, E. , Debelius, J. W. , Morton, J. T. , Gonzalez, A. , Ackermann, G. , Aksenov, A. A. , Behsaz, B. , Brennan, C. , Chen, Y. , DeRight Goldasich, L. , Dorrestein, P. C. , Dunn, R. R. , Fahimipour, A. K. , Gaffney, J. , Gilbert, J. A. , Gogul, G. , Green, J. L. , Hugenholtz, P. , Humphrey, G. & 39 others Huttenhower, C., Jackson, M. A., Janssen, S., Jeste, D. V., Jiang, L., Kelley, S. T., Knights, D., Kosciolek, T., Ladau, J., Leach, J., Marotz, C., Meleshko, D., Melnik, A. V., Metcalf, J. L., Mohimani, H., Montassier, E., Navas-Molina, J., Nguyen, T. T., Peddada, S., Pevzner, P., Pollard, K. S., Rahnavard, G., Robbins-Pianka, A., Sangwan, N., Shorenstein, J., Smarr, L., Song, S. J., Spector, T., Swafford, A. D., Thackray, V. G., Thompson, L. R., Tripathi, A., Vazquez-Baeza, Y., Vrbanac, A., Wischmeyer, P., Wolfe, E., Zhu, Q., American Gut Consortium & Knight, R. 26 May 2018 In : mSystems. 3, 3

    Research output: Contribution to journalArticle

  24. Gut microbial diversity is associated with lower arterial stiffness in women

    Menni, C., Lin, C., Cecelja, M., Mangino, M., Matey-Hernandez, M. L., Keehn, L., Mohney, R. P., Steves, C. J., Spector, T. D., Kuo, C-F., Chowienczyk, P. & Valdes, A. M. 9 May 2018 In : European Heart Journal. 39, 12, p. 2390a-2397a

    Research output: Contribution to journalArticle

  25. Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

    Visconti, A. , Duffy, D. , Liu, F. , Zhu, G. , Wu, W. , Chen, Y. , Hysi, P. , Zeng, C. , Sanna, M. , Iles, M. M. , Kanetsky, P. A. , Demenais, F. , Hamer, M. A. , Uitterlinden, A. G. , Ikram, M. A. , Nijsten, T. E. C. , Martin, N. G. , Kayser, M. , Spector, T. D. , Han, J. & 2 others Bataille, V. & Falchi, M. 8 May 2018 In : Nature Communications. 1684

    Research output: Contribution to journalArticle

  26. Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

    Lin, H. , van Setten, J. , Smith, A. V. , Bihlmeyer, N. A. , Warren, H. R. , Brody, J. A. , Radmanesh, F. , Hall, L. , Grarup, N. , Müller-Nurasyid, M. , Boutin, T. , Verweij, N. , Lin, H. J. , Li-Gao, R. , van den Berg, M. E. , Marten, J. , Weiss, S. , Prins, B. P. , Haessler, J. , Lyytikäinen, L-P. & 81 others Mei, H., Harris, T. B., Launer, L. J., Li, M., Alonso, A., Soliman, E. Z., Connell, J. M., Huang, P. L., Weng, L-C., Jameson, H. S., Hucker, W., Hanley, A., Tucker, N. R., Chen, Y-D. I., Bis, J. C., Rice, K. M., Sitlani, C. M., Kors, J. A., Xie, Z., Wen, C., Magnani, J. W., Nelson, C. P., Kanters, J. K., Sinner, M. F., Strauch, K., Peters, A., Waldenberger, M., Meitinger, T., Bork-Jensen, J., Pedersen, O., Linneberg, A., Rudan, I., de Boer, R. A., van der Meer, P., Yao, J., Guo, X., Taylor, K. D., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Trompet, S., Rivadeneira, F., Uitterlinden, A., Eijgelsheim, M., Padmanabhan, S., Smith, B. H., Völzke, H., Felix, S. B., Homuth, G., Völker, U., Mangino, M., Bots, M. L., Perez, M., Kähönen, M., Raitakari, O. T., Gudnason, V., Arking, D. E., Munroe, P. B., Psaty, B. M., van Duijn, C. M., Benjamin, E. J., Rosand, J., Samani, N. J., Hansen, T., Kääb, S., Polasek, O., van der Harst, P., Heckbert, S. R., Jukema, J. W., Stricker, B. H., Hayward, C., Dörr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimäki, T., Wilson, J. G., Ellinor, P. T., Lubitz, S. A., Isaacs, A. & Spector, T. D. May 2018 In : Circulation. Genomic and precision medicine. 11, 5, e002037

    Research output: Contribution to journalArticle

  27. Use of dietary indices to control for diet in human gut microbiota studies

    Bowyer, R. C. E., Jackson, M. A., Pallister, T., Skinner, J., Spector, T. D., Welch, A. A. & Steves, C. J. 25 Apr 2018 In : Microbiome. 6, 1, p. 77

    Research output: Contribution to journalArticle

  28. Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability

    Hysi, P. , Valdes, A. M. , Liu, F. , Furlotte, N. A. , Evans, D. M. , Bataille, V. , Visconti, A. , Hemani, G. , McMahon, G. , Ring, S. M. , Smith, G. D. , Duffy, D. L. , Zhu, G. , Gordon, S. D. , Medland, S. E. , Danae Lin, B. , Willemsen, G. , Hottenga, J-J. , Vuckovic, D. , Girotto, G. & 23 others Gandin, I., Sala, C., Brumat, M., Gasparini, P., Daniela, T., Cocca, M., Robino, A., Yazar, S., Hewitt, A. W., Chen, Y., Zeng, C., Uitterlinden, A. G., Ikram, M. A., Hamer, M. A., van Duijn, C. M., Nijsten, T. E. C., Mackey, D. A., Falchi, M., Boomsma, D. I., Martin, N. G., Hinds, D. A., Kayser, M. & Spector, T. D. 16 Apr 2018 In : Nature Genetics.

    Research output: Contribution to journalLetter

  29. Definitive zygosity scores in the peas in the pod questionnaire is a sensitive and accurate assessment of the zygosity of adult twins

    Jarrar, Z. A., Ward, K. J., Mangino, M., Cherkas, L. F., Gill, R., Gillham-Nasenya, I., Yarand, D., Hart, D., Hammond, C. J. & Spector, T. D. Apr 2018 In : TWIN RESEARCH AND HUMAN GENETICS. 21, 2, p. 146-154

    Research output: Contribution to journalArticle

  30. Metabolomic pathways to osteoporosis in middle-aged women: a genome-metabolome-wide Mendelian randomization study

    Moayyeri, A., Cheung, C-L., Tan, K. C., Morris, J. A., Cerani, A., Mohney, R. P., Richard, J. B., Hammond, C., Spector, T. D. & Menni, C. Apr 2018 In : Journal of Bone and Mineral Research. 33, 4, p. 643-650

    Research output: Contribution to journalArticle

  31. Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated with Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts

    Menni, C., Gudelj, I., MacDonald-Dunlop, E., Mangino, M., Zierer, J., Bešić, E., Joshi, P., Trbojević-Akmačić, I., Chowienczyk, P. J., Spector, T. D., Wilson, J. F., Lauc, G. & Valdes, A. M. 16 Mar 2018 In : Circulation Research. 122, 11, p. 1555-1564

    Research output: Contribution to journalArticle

  32. Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

    Mullaney, J. A., Stephens, J. E., Costello, M. E., Fong, C., Geeling, B. E., Gavin, P. G., Wright, C. M., Spector, T. D., Brown, M. A. & Hamilton-Williams, E. E. 17 Feb 2018 In : Microbiome. 6, 1, 35

    Research output: Contribution to journalArticle

  33. Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

    Cohen, I. V., Cirulli, E. T., Mitchell, M. W., Jonsson, T. J., Yu, J., Shah, N., Spector, T. D., Guo, L., Venter, J. C. & Telenti, A. 15 Feb 2018 In : EBioMedicine.

    Research output: Contribution to journalArticle

  34. Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

    Viñuela, A., Brown, A. A., Buil, A., Tsai, P-C., Davies, M. N., Bell, J. T., Dermitzakis, E. T., Spector, T. D. & Small, K. S. 15 Feb 2018 In : Human Molecular Genetics. 27, 4, p. 732–741

    Research output: Contribution to journalArticle

  35. Detection of stable community structures within gut microbiota co-occurrence networks from different human populations

    Jackson, M. A., Bonder, M. J., Kuncheva, Z., Zierer, J., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., Bell, J. T., Spector, T. D. & Steves, C. J. 7 Feb 2018 In : PeerJ. 6, p. e4303

    Research output: Contribution to journalArticle

  36. Genetic and microbiome influence on lipid metabolism and dyslipidemia

    Matey-Hernandez, M. L., Williams, F. M. K., Potter, T., Valdes, A. M., Spector, T. D. & Menni, C. 1 Feb 2018 In : PHYSIOLOGICAL GENOMICS. 50, 2, p. 117-126 10 p.

    Research output: Contribution to journalArticle

  37. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

    Jiang, X. , O'Reilly, P. F. , Aschard, H. , Hsu, Y. H. , Richards, J. B. , Dupuis, J. , Ingelsson, E. , Karasik, D. , Pilz, S. , Berry, DI. , Kestenbaum, B. , Zheng, J. , Luan, J. , Sofianopoulou, E. , Streeten, E. A. , Albanes, D. , Lutsey, P. L. , Yao, L. , Tang, W. , Econs, M. J. & 30 others Wallaschofski, H., Völzke, H., Zhou, A., Power, C., McCarthy, M. I., Michos, E. D., Boerwinkle, E., Weinstein, S. J., Freedman, N. D., Huang, W. Y., Van Schoor, N. M., Van Der Velde, N., Groot, L. C. P. G. M. D., Enneman, A., Cupples, L. A., Booth, S. L., Vasan, R. S., Liu, C. T., Zhou, Y., Ripatti, S., Ohlsson, C., Vandenput, L., Lorentzon, M., Eriksson, J. G., Shea, M. K., Houston, D. K., Kritchevsky, S. B., Liu, Y., Valdes, A. M. & Spector, T. 17 Jan 2018 In : Nature Communications. 9, 1, 260

    Research output: Contribution to journalArticle

  38. Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

    Zaghlool, S. B. , Mook-Kanamori, D. O. , Kader, S. , Stephan, N. , Halama, A. , Engelke, R. , Sarwath, H. , Al-Dous, E. K. , Mohamoud, Y. A. , Roemisch-Margl, W. , Adamski, J. , Kastenmüller, G. , Friedrich, N. , Visconti, A. , Tsai, P-C. , Spector, T. , Bell, J. , Falchi, M. , Wahl, A. , Waldenberger, M. & 7 others Peters, A., Gieger, C., Pezer, M., Lauc, G., Graumann, J., Malek, J. A. & Suhre, K. 8 Jan 2018 In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  39. Ensemble landmarking of 3D facial surface scans

    de Jong, M. A., Hysi, P., Spector, T., Niessen, W., Koudstaal, M. J., Wolvius, E. B., Kayser, M. & Böhringer, S. 8 Jan 2018 In : Scientific Reports. 8, 1, p. 12

    Research output: Contribution to journalArticle

  40. Meta-analysis of epigenome-wide association studies of cognitive abilities

    Marioni, R. E. , McRae, A. F. , Bressler, J. , Colicino, E. , Hannon, E. , Li, S. , Prada, D. , Smith, J. A. , Trevisi, L. , Tsai, P-C. , Vojinovic, D. , Simino, J. , Levy, D. , Liu, C. , Mendelson, M. , Satizabal, C. L. , Yang, Q. , Jhun, M. A. , Kardia, S. L. R. , Zhao, W. & 27 others Bandinelli, S., Ferrucci, L., Hernandez, D. G., Singleton, A. B., Harris, S. E., Starr, J. M., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y-H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I. J. 8 Jan 2018 In : Molecular Psychiatry. 23, 11, p. 2133-2144

    Research output: Contribution to journalArticle

  41. Genetics of the human face: Identification of large-effect single gene variants

    Crouch, D. J. M., Winney, B., Koppen, W. P., Christmas, W. J., Hutnik, K., Day, T., Meena, D., Boumertit, A., Hysi, P., Nessa, A., Spector, T. D., Kittler, J. & Bodmer, W. F. 4 Jan 2018 In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  42. Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

    Medina-Gomez, C. , Kemp, J. P. , Trajanoska, K. , Luan, J. , Chesi, A. , Ahluwalia, T. S. , Mook-Kanamori, D. O. , Ham, A. , Hartwig, F. P. , Evans, D. S. , Joro, R. , Nedeljkovic, I. , Zheng, H-F. , Zhu, K. , Atalay, M. , Liu, C-T. , Nethander, M. , Broer, L. , Porleifsson, G. , Mullin, B. H. & 69 others Handelman, S. K., Nalls, M. A., Jessen, L. E., Heppe, D. H. M., Richards, J. B., Wang, C., Chawes, B., Schraut, K. E., Amin, N., Wareham, N., Karasik, D., Van der Velde, N., Ikram, M. A., Zemel, B. S., Zhou, Y., Carlsson, C. J., Liu, Y., McGuigan, F. E., Boer, C. G., Bønnelykke, K., Ralston, S. H., Robbins, J. A., Walsh, J. P., Zillikens, M. C., Langenberg, C., Li-Gao, R., Williams, F. M. K., Harris, T. B., Akesson, K., Jackson, R. D., Sigurdsson, G., den Heijer, M., van der Eerden, B. C. J., van de Peppel, J., Spector, T. D., Pennell, C., Horta, B. L., Felix, J. F., Zhao, J. H., Wilson, S. G., de Mutsert, R., Bisgaard, H., Styrkársdóttir, U., Jaddoe, V. W., Orwoll, E., Lakka, T. A., Scott, R., Grant, S. F. A., Lorentzon, M., van Duijn, C. M., Wilson, J. F., Stefansson, K., Psaty, B. M., Kiel, D. P., Ohlsson, C., Ntzani, E., van Wijnen, A. J., Forgetta, V., Ghanbari, M., Logan, J. G., Williams, G. R., Bassett, J. H. D., Croucher, P. I., Evangelou, E., Uitterlinden, A. G., Ackert-Bicknell, C. L., Tobias, J. H., Evans, D. M. & Rivadeneira, F. 4 Jan 2018 In : American Journal of Human Genetics. 102, 1, p. 88-102 15 p.

    Research output: Contribution to journalArticle

  43. Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

    Beaumont, R. N. , Warrington, N. M. , Cavadino, A. , Tyrrell, J. , Nodzenski, M. , Horikoshi, M. , Geller, F. , Myhre, R. , Richmond, R. C. , Paternoster, L. , Bradfield, J. P. , Kreiner-Møller, E. , Huikari, V. , Metrustry, S. , Lunetta, K. L. , Painter, J. N. , Hottenga, J-J. , Allard, C. , Barton, S. J. , Espinosa, A. & 31 others Marsh, J. A., Potter, C., Zhang, G., Ang, W., Berry, D. J., Bouchard, L., Das, S., Hakonarson, H., Heikkinen, J., Helgeland, Ø., Hocher, B., Hofman, A., Inskip, H. M., Jones, S. E., Kogevinas, M., Lind, P. A., Marullo, L., Medland, S. E., Murray, A., Murray, J. C., Njølstad, P. R., Nohr, E. A., Reichetzeder, C., Ring, S. M., Ruth, K. S., Santa-Marina, L., Scholtens, D. M., Sebert, S., Sengpiel, V., Spector, T. D. & Early Growth Genetics (EGG) Consortium 3 Jan 2018 In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  44. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Turcot, V. , Lu, Y. , Highland, H. M. , Schurmann, C. , Justice, A. E. , Fine, R. S. , Bradfield, J. P. , Esko, T. , Giri, A. , Graff, M. , Guo, X. , Hendricks, A. E. , Karaderi, T. , Lempradl, A. , Locke, A. E. , Mahajan, A. , Marouli, E. , Sivapalaratnam, S. , Young, K. L. , Alfred, T. & 31 others Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Breen, G., Small, K. S., Spector, T. D. & CHD Exome+ Consortium Jan 2018 In : Nature Genetics. 50, 1, p. 26-41 16 p.

    Research output: Contribution to journalArticle

  45. Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women

    Sanchez-Santos, MT., Judge, A., Gulati, M., Spector, TD., Hart, DJ., Newton, JL., Arden, NK. & Kluzek, S. 2018 In : Seminars in Arthritis and Rheumatism.

    Research output: Contribution to journalArticle

  46. Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress

    Metrustry, S. J., Karhunen, V., Edwards, M. H., Menni, C., Geisendorfer, T., Huber, A., Reichel, C., Dennison, E. M., Cooper, C., Spector, T., Jarvelin, M-R. & Valdes, A. M. 2018 In : PloS one. 13, 3, p. e0194316

    Research output: Contribution to journalArticle

  47. 2017
  48. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

    Jason, F. , Fuchsberger, C. , Mahajan, A. , Teslovich, T. M. , Agarwala, V. , Gaulton, K. J. , Caulkins, L. , Koesterer, R. , Ma, C. , Moutsianas, L. , McCarthy, D. J. , Rivas, M. A. , Perry, J. R. B. , Sim, X. , Blackwell, T. W. , Robertson, N. R. , Rayner, N. W. , Cingolani, P. , Locke, A. E. , Tajes, J. F. & 281 others Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., van de Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B-J., Kim, Y., Kim, Y. J., Kwon, M-S., Lee, J., Lee, S., Lin, K-H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B-G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S-H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C-Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C-C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S-T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., de Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A-C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J-Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E. S., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I. 19 Dec 2017 In : Scientific Data. 4, p. 170179

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