King's College London

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Research Outputs

  1. 2018
  2. Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

    Smith, R. G., Hannon, E., De Jager, P. L., Chibnik, L., Lott, S. J., Condliffe, D., Smith, A. R., Haroutunian, V., Troakes, C., Al-Sarraj, S., Bennett, D. A., Powell, J., Lovestone, S., Schalkwyk, L., Mill, J. & Lunnon, K. 15 Mar 2018 In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  3. Heterogeneous patterns of brain atrophy in Alzheimer's disease

    Poulakis, K., Pereira, J. B., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Soininen, H., Lovestone, S., Simmons, A., Wahlund, L-O. & Westman, E. 31 Jan 2018 In : Neurobiology of Aging.

    Research output: Contribution to journalArticle

  4. 2017
  5. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

    Horgusluoglu-Moloch, E., Nho, K., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Petersen, R. C., Jack, C. R., Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J. 1 Dec 2017 In : Neurobiology of Aging. 60, p. 92-103 12 p.

    Research output: Contribution to journalArticle

  6. DISCOVERY, REPLICATION AND EXTENSION STUDY OF PLASMA PROTEOMIC BIOMARKERS RELATING TO BRAIN AMYLOID BURDEN (CSF Aβ OR AMYLOID-PET) IN THE EMIF-AD BIOMARKER DISCOVERY COHORT: 2017 Abstract Supplement

    Westwood, S. , Baird, A. L. , Hye, A. , Bos, I. , Vos, S. J. B. , Vandenberghe, R. , Scheltens, P. , Engelborghs, S. , Frisoni, G. B. , Molinuevo, J. L. , Wallin, A. , Lleó, A. , Popp, J. , Martinez-Lage, P. , Snowden, S. G. , Legido-Quigley, C. , Bertram, L. , Barkhof, F. , Zetterberg, H. , Streffer, J. & 2 others Visser, P. J. & Lovestone, S. 20 Oct 2017 In : Alzheimer's & Dementia. 13, 7, Supplement, p. P361-P362

    Research output: Contribution to journalArticle

  7. Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

    Sellers, K. J. , Elliott, C. , Jackson, J. , Ghosh, A. , Ribe, E. , Rojo-Sanchís, A. , Jarosz-Griffiths, H. H. , Watson, I. A. , Xia, W. , Semenov, M. , Morin, P. , Hooper, N. M. , Porter, R. , Preston, J. , Al-Shawi, R. , Baillie, G. , Lovestone, S. , Cuadrado, A. , Harte, M. , Simons, P. & 2 others Srivastava, D. P. & Killick, R. 19 Oct 2017 In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  8. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A. 5 Jul 2017 In : Redox Biology.

    Research output: Contribution to journalArticle

  9. Mitochondrial genes are altered in blood early in Alzheimer's disease

    Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A. 1 May 2017 In : Neurobiology of Aging. 53, p. 36-47 12 p.

    Research output: Contribution to journalArticle

  10. A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease

    Khan, W. , Giampietro, V. , Banaschewski, T. , Barker, G. J. , Bokde, A. L. W. , Büchel, C. , Conrod, P. , Flor, H. , Frouin, V. , Garavan, H. , Gowland, P. , Heinz, A. , Ittermann, B. , Lemaître, H. , Nees, F. , Paus, T. , Pausova, Z. , Rietschel, M. , Smolka, M. N. , Ströhle, A. & 19 others Gallinat, J., Vellas, B., Soininen, H., Kloszewska, I., Tsolaki, M., Mecocci, P., Spenger, C., Villemagne, V. L., Masters, C. L., Muehlboeck, J. S., Bäckman, L., Fratiglioni, L., Kalpouzos, G., Wahlund, L. O., Schumann, G., Lovestone, S., Williams, S. C. R., Westman, E. & Simmons, A. 3 Feb 2017 In : JOURNAL OF ALZHEIMERS DISEASE. 56, 3, p. 1159-1174 16 p.

    Research output: Contribution to journalArticle

  11. Novel genetic loci associated with hippocampal volume

    Hibar, D. P. , Adams, H. H. H. , Jahanshad, N. , Chauhan, G. , Stein, J. L. , Hofer, E. , Renteria, M. E. , Bis, J. C. , Arias-Vasquez, A. , Ikram, M. K. , Desrivières, S. , Vernooij, M. W. , Abramovic, L. , Alhusaini, S. , Amin, N. , Andersson, M. , Arfanakis, K. , Aribisala, B. S. , Armstrong, N. J. , Athanasiu, L. & 312 others Axelsson, T., Beecham, A. H., Beiser, A., Bernard, M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chen, Q., Ching, C. R. K., Chouraki, V., Cuellar-Partida, G., Crivello, F., Den Braber, A., Doan, N. T., Ehrlich, S., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Grimm, O., Griswold, M. E., Guadalupe, T., Gutman, B. A., Hass, J., Haukvik, U. K., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Jørgensen, K. N., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A. F., Matarin, M., Mather, K. A., Mattheisen, M., McKay, D. R., Milaneschi, Y., Muñoz Maniega, S., Nho, K., Nugent, A. C., Nyquist, P., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pirpamer, L., Pütz, B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Ropele, S., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Saremi, A., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Trompet, S., Vaidya, D., Van der Grond, J., Van der Lee, S. J., Van der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Wolfers, T., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Cheng, C-Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Craen, A. J. M., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Deary, I. J., Debette, S., DeCarli, C., Delanty, N., Depondt, C., DeStefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Enzinger, C., Erk, S., Espeseth, T., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Fornage, M., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Håberg, A. K., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B-C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J-J., Huentelman, M., Pol, H. E. H., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J-L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schmidt, H., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Tsolaki, M., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van der Brug, M., van der Lugt, A., van der Wee, N. J. A., Van Haren, N. E. M., van 't Ent, D., Van Tol, M-J., Vardarajan, B. N., Vellas, B., Veltman, D. J., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., Martin, N. G., Van Duijn, C. M., Wright, M. J., Longstreth, W. T., Schumann, G., Grabe, H. J., Franke, B., Launer, L. J., Medland, S. E., Seshadri, S., Thompson, P. M. & Ikram, M. A. 18 Jan 2017 In : Nature communications. 8, p. 13624 12 p.

    Research output: Contribution to journalArticle

  12. 2016
  13. Better together for better dementia research and care

    Lovestone, S., Rossor, M., Gallacher, J., Ritchie, C., Burn, D., Hyslop, P. S. G., Mackay, C., Matthews, P. M., Ballard, C. & Georges, J. 17 May 2016 In : The Lancet Psychiatry.

    Research output: Contribution to journalComment/debate

  14. Shared genetic contribution to ischemic stroke and Alzheimer's disease: Ischemic Stroke and Alzheimer's Disease

    Traylor, M., Adib-samii, P., Harold, D., Dichgans, M., Williams, J., Lewis, C. M., Markus, H. S., METASTROKE and International Genomics of Alzheimer's Project (IGAP) investigators, Lovestone, S. H. & Proitsi, P. 1 May 2016 In : Annals of Neurology. 79, 5, p. 739-747

    Research output: Contribution to journalArticle

  15. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

    Allen, G. I. , Amoroso, N. , Anghel, C. , Balagurusamy, V. , Bare, C. J. , Beaton, D. , Bellotti, R. , Bennett, D. A. , Boehme, K. L. , Boutros, P. C. , Caberlotto, L. , Caloian, C. , Campbell, F. , Chaibub Neto, E. , Chang, Y-C. , Chen, B. , Chen, C-Y. , Chien, T-Y. , Clark, T. , Das, S. & 81 others Davatzikos, C., Deng, J., Dillenberger, D., Dobson, R. J. B., Dong, Q., Doshi, J., Duma, D., Errico, R., Erus, G., Everett, E., Fardo, D. W., Friend, S. H., Fröhlich, H., Gan, J., St George-Hyslop, P., Ghosh, S. S., Glaab, E., Green, R. C., Guan, Y., Hong, M-Y., Huang, C., Hwang, J., Ibrahim, J., Inglese, P., Iyappan, A., Jiang, Q., Katsumata, Y., Kauwe, J. S. K., Klein, A., Kong, D., Krause, R., Lalonde, E., Lauria, M., Lee, E., Lin, X., Liu, Z., Livingstone, J., Logsdon, B. A., Lovestone, S., Ma, T., Malhotra, A., Mangravite, L. M., Maxwell, T. J., Merrill, E., Nagorski, J., Namasivayam, A., Narayan, M., Naz, M., Newhouse, S. J., Norman, T. C., Nurtdinov, R. N., Oyang, Y-J., Pawitan, Y., Peng, S., Peters, M. A., Piccolo, S. R., Praveen, P., Priami, C., Sabelnykova, V. Y., Senger, P., Shen, X., Simmons, A., Sotiras, A., Stolovitzky, G., Tangaro, S., Tateo, A., Tung, Y-A., Tustison, N. J., Varol, E., Vradenburg, G., Weiner, M. W., Xiao, G., Xie, L., Xie, Y., Xu, J., Yang, H., Zhan, X., Zhou, Y., Zhu, F., Zhu, H. & Zhu, S. 11 Apr 2016 In : Alzheimer's & Dementia. 12, 6, p. 645-653 9 p.

    Research output: Contribution to journalArticle

  16. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

    Lupton, M. K. , Strike, L. , Hansell, N. K. , Wen, W. , Mather, K. A. , Armstrong, N. J. , Thalamuthu, A. , McMahon, K. L. , de Zubicaray, G. I. , Assareh, A. A. , Simmons, A. , Proitsi, P. , Powell, J. F. , Montgomery, G. W. , Hibar, D. P. , Westman, E. , Tsolaki, M. , Kloszewska, I. , Soininen, H. , Mecocci, P. & 9 others Velas, B., Lovestone, S., Brodaty, H., Ames, D., Trollor, J. N., Martin, N. G., Thompson, P. M., Sachdev, P. S. & Wright, M. J. 1 Apr 2016 In : Neurobiology of Aging. 40, p. 68-77 10 p.

    Research output: Contribution to journalArticle

  17. The Effect of Age Correction on Multivariate Classification in Alzheimer’s Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects

    Falahati, F., Ferreira, D., Soininen, H., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Lovestone, S., Eriksdotter, M., Wahlund, L. O., Simmons, A. & Westman, E. 1 Mar 2016 In : Brain Topography. 29, 2, p. 296-307 12 p.

    Research output: Contribution to journalArticle

  18. A pathway based classification method for analyzing gene expression for Alzheimer's disease diagnosis

    Voyle, N., Keohane, A., Newhouse, S., Lunnon, K., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A., Kiddle, S. & Dobson, R. J. B. 2016 In : JOURNAL OF ALZHEIMERS DISEASE. 49, 3, p. 659-669 11 p.

    Research output: Contribution to journalArticle

  19. Novel genetic loci underlying human intracranial volume identified through genome-wide association

    Adams, H. H. H. , Hibar, D. P. , Chouraki, V. , Stein, J. L. , Nyquist, P. A. , Rentería, M. E. , Trompet, S. , Arias-vasquez, A. , Seshadri, S. , Desrivières, S. , Beecham, A. H. , Jahanshad, N. , Wittfeld, K. , Van Der Lee, S. J. , Abramovic, L. , Alhusaini, S. , Amin, N. , Andersson, M. , Arfanakis, K. , Aribisala, B. S. & 322 others Armstrong, N. J., Athanasiu, L., Axelsson, T., Beiser, A., Bernard, M., Bis, J. C., Blanken, L. M. E., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chauhan, G., Chen, Q., Ching, C. R. K., Cuellar-partida, G., Braber, A. D., Doan, N. T., Ehrlich, S., Filippi, I., Ge, T., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Greven, C. U., Grimm, O., Griswold, M. E., Guadalupe, T., Hass, J., Haukvik, U. K., Hilal, S., Hofer, E., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liao, J., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A., Matarin, M., Mather, K. A., Mattheisen, M., Mazoyer, B., Mckay, D. R., Mcwhirter, R., Milaneschi, Y., Mirza-schreiber, N., Muetzel, R. L., Maniega, S. M., Nho, K., Nugent, A. C., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pappa, I., Pirpamer, L., Pudas, S., Pütz, B., Rajan, K. B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-santiañez, R., Rommelse, N., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Thomson, R., Tordesillas-gutierrez, D., Toro, R., Trabzuni, D., Vaidya, D., Van Der Grond, J., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Woldehawariat, G., Wolf, C., Wolfers, T., Xu, B., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Aggarwal, N. T., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Chen, C., Cheng, C., Cichon, S., Cookson, M. R., Corvin, A., Crespo-facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Delanty, N., Depondt, C., Destefano, A. L., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Erk, S., Espeseth, T., Evans, D. A., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Grabe, H. J., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J., Pol, H. E. H., Ikeda, M., Ikram, M. K., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Longstreth, W. T., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J., Mattay, V. S., Mcdonald, C., Mcintosh, A. M., Mcmahon, K. L., Mcmahon, F. J., Mecocci, P., Melle, I., Meyer-lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schofield, P. R., Sigurdsson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Srikanth, V., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Tiemeier, H., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van Der Brug, M., Van Der Lugt, A., Van Der Wee, N. J. A., Van Duijn, C. M., Van Haren, N. E. M., Van ′t Ent, D., Van Tol, M., Vardarajan, B. N., Veltman, D. J., Vernooij, M. W., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, H. R., Zonderman, A. B., Deary, I. J., Decarli, C., Schmidt, H., Martin, N. G., De Craen, A. J. M., Wright, M. J., Launer, L. J., Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S. E., Ikram, M. A. & Thompson, P. M. 2016 In : Nature Neuroscience. 19, 12, p. 1569-1582

    Research output: Contribution to journalArticle

  20. 2015
  21. Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease

    Sattlecker, M., Khondoker, M., Proitsi, P., Williams, S., Soininen, H., K??oszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S. & Dobson, R. J. 23 Nov 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 49, 4, p. 1105-1114 10 p.

    Research output: Contribution to journalArticle

  22. A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease

    Khan, W., Aguilar, C., Kiddle, S. J., Doyle, O., Thambisetty, M., Muehlboeck, S., Sattlecker, M., Newhouse, S., Lovestone, S., Dobson, R., Giampietro, V., Westman, E., Simmons, A. & Alzheimer’s Disease Neuroimaging Initiative 18 Aug 2015 In : PloS one. 10, 8, 16 p., e0134368

    Research output: Contribution to journalArticle

  23. Tract based spatial statistic reveals no differences in white matter microstructural organization between carriers and non-carriers of the APOE ε4 and ε2 alleles in young healthy adolescents

    Dell'Acqua, F. , Khan, W. , Gottlieb, N. , Giampietro, V. , Ginestet, C. , Bouls, D. , Newhouse, S. , Dobson, R. , Banaschewski, T. , Barker, G. J. , Bokde, A. L. W. , Büchel, C. , Conrod, P. , Flor, H. , Frouin, V. , Garavan, H. , Gowland, P. , Heinz, A. , Lemaítre, H. , Nees, F. & 10 others Paus, T., Pausova, Z., Rietschel, M., Smolka, M. N., Ströhle, A., Gallinat, J., Westman, E., Schumann, G., Lovestone, S. & Simmons, A. 11 Aug 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 47, 4, p. 977-984 8 p.

    Research output: Contribution to journalArticle

  24. No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease

    Chiam, J. T. W., Lunnon, K., Voyle, N., Proitsi, P., Coppola, G., Geschwind, D., Nelson, S., Johnston, C., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Hodges, A., Lovestone, S., Newhouse, S., Dobson, R. J. B., Kiddle, S. J. & Sattlecker, M. 3 Aug 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 47, 3, p. 741-750 10 p.

    Research output: Contribution to journalArticle

  25. Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology.

    Voyle, N., Baker, D., Burnham, S. C., Covin, A., Zhang, Z., Sangurdekar, D. P., Tan, H. C. A., Bazenet, C., Lovestone, S., Kiddle, S. & Dobson, R. J. B. 26 Jun 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 46, 4, p. 947-961 15 p.

    Research output: Contribution to journalArticle

  26. Plasma protein biomarkers of Alzheimer’s disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

    Kiddle, S. J. , Steves, C. J. , Mehta, M. , Simmons, A. , Xu, X. , Newhouse, S. , Sattlecker, M. , Ashton, N. , Bazenet, C. , Killick, R. , Adnan, J. , Westman, E. , Nelson, S. , Soininen, H. , Kloszewska, I. , Mecocci, P. , Tsolaki, M. , Vellas, B. , Curtis, C. , Breen, G. & 4 others Williams, S. C. R., Lovestone, S., Spector, T. D. & Dobson, R. J. B. 16 Jun 2015 In : Translational psychiatry. 5, 6, 6 p., e584

    Research output: Contribution to journalArticle

  27. Convergent genetic and expression data implicate immunity in Alzheimer's disease

    International Genomics of Alzheimer's Disease Consortium (IGAP)†, Jun 2015 In : Alzheimer's & Dementia. 11, 6, p. 658-671

    Research output: Contribution to journalArticle

  28. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

    O'Bryant, S. E. , Gupta, V. , Henriksen, K. , Edwards, M. , Jeromin, A. , Lista, S. , Bazenet, C. , Soares, H. , Lovestone, S. , Hampel, H. , Montine, T. , Blennow, K. , Foroud, T. , Carrillo, M. , Graff-Radford, N. , Laske, C. , Breteler, M. , Shaw, L. , Trojanowski, J. Q. , Schupf, N. & 8 others Rissman, R. A., Fagan, A. M., Oberoi, P., Umek, R., Weiner, M. W., Grammas, P., Posner, H. & Martins, R. 1 May 2015 In : Alzheimer's & Dementia. 11, 5, p. 549-560 12 p.

    Research output: Contribution to journalArticle

  29. Common genetic variants influence human subcortical brain structures

    Hibar, D. P. , Stein, J. L. , Renteria, M. E. , Arias-Vasquez, A. , Desrivières, S. , Jahanshad, N. , Toro, R. , Wittfeld, K. , Abramovic, L. , Andersson, M. , Aribisala, B. S. , Armstrong, N. J. , Bernard, M. , Bohlken, M. M. , Boks, M. P. , Bralten, J. , Brown, A. A. , Mallar Chakravarty, M. , Chen, Q. , Ching, C. R. K. & 31 others Cuellar-Partida, G., den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Macare, C., Ramasamy, A., Walton, E., Johnson, R., Perez-Iglesias, R., Schofield, P. R., Williams, R. W., Davies, G. E., Fisher, S. E., Lovestone, S., McDonald, C., Simmons, A., Weale, M. E., Schumann, G. & The Alzheimer’s Disease Neuroimaging Initiative 9 Apr 2015 In : NATURE. 520, 7546, p. 224-+ 21 p.

    Research output: Contribution to journalArticle

  30. Blood protein predictors of brain amyloid for enrichment in clinical trials?

    Ashton, N., Kiddle, S., Graf, J., Ward, M., Baird, A., Hye, A., Westwood, S., Wong, K. V., Dobson, R., Rabinovici, G., Miller, B., Rosen, H., Torres, A., Zhang, Z., Thurfjell, L., Covin, A., Hehir, C., Baker, D., Bazenet, C. & Lovestone, S. 29 Mar 2015 In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1, 1, p. 48-60 13 p.

    Research output: Contribution to journalArticle

  31. Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

    Khondoker, M., Newhouse, S., Westman, E., Muehlboeck, J-S., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Soininen, H., Lovestone, S., Dobson, R. & Simmons, A. 2015 In : Journal of Alzheimer's disease : JAD. 45, 3, p. 851-864 14 p.

    Research output: Contribution to journalArticle

  32. Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment

    Ferreira, D., Cavallin, L., Larsson, E-M., Muehlboeck, J-S., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Soininen, H., Lovestone, S., Simmons, A., Wahlund, L-O., Westman, E. & The AddNeuroMed consortium, the Alzheimer's Disease Neuroimaging, Initiative 2015 In : Journal of Internal Medicine. 14 p.

    Research output: Contribution to journalArticle

  33. Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

    Vos, S. J. B. , Verhey, F. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. , Nobili, F. , Morbelli, S. , Frisoni, G. B. , Drzezga, A. , Didic, M. , van Berckel, B. N. M. , Simmons, A. , Soininen, H. , Kłoszewska, I. , Mecocci, P. , Tsolaki, M. , Vellas, B. & 20 others Lovestone, S., Muscio, C., Herukka, S-K., Salmon, E., Bastin, C., Wallin, A., Nordlund, A., de Mendonça, A., Silva, D., Santana, I., Lemos, R., Engelborghs, S., Van der Mussele, S., Freund-Levi, Y., Wallin, Å. K., Hampel, H., van der Flier, W., Scheltens, P., Visser, P. J. & The Alzheimer’s Disease Neuroimaging Initiative 2015 In : Brain. 12 p.

    Research output: Contribution to journalArticle

  34. Protective variant for hippocampal atrophy identified by whole exome sequencing

    Nho, K. , Kim, S. , Risacher, S. L. , Shen, L. , Corneveaux, J. J. , Swaminathan, S. , Lin, H. , Ramanan, V. K. , Liu, Y. , Foroud, T. M. , Inlow, M. H. , Siniard, A. L. , Reiman, R. A. , Aisen, P. S. , Petersen, R. C. , Green, R. C. , Jack, C. R. , Weiner, M. W. , Baldwin, C. T. , Lunetta, K. L. & 15 others Farrer, L. A., Furney, S. J., Lovestone, S., Simmons, A., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., McDonald, B. C., Farlow, M. R., Ghetti, B., Huentelman, M. J., Saykin, A. J. & for the Indiana Memory, Aging Study 2015 In : Annals of neurology.

    Research output: Contribution to journalArticle

  35. 2014
  36. Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease

    Proitsi, P. , Lupton, M. K. , Velayudhan, L. , Hunter, G. , Newhouse, S. , Lin, K. , Fogh, I. , Tsolaki, M. , Daniilidou, M. , Pritchard, M. , Craig, D. , Todd, S. , Johnston, J. A. , McGuinness, B. , Kloszewska, I. , Soininen, H. , Mecocci, P. , Vellas, B. , Passmore, P. A. , Sims, R. & 7 others Williams, J., Brayne, C., Stewart, R., Sham, P., Lovestone, S., Powell, J. F. & Alzheimer's Disease Neuroimaging Initiative Dec 2014 In : Neurobiology of Aging. 35, 12, p. 2883.e3-2883.e10 8 p., 2883

    Research output: Contribution to journalArticle

  37. Plasma proteins predict conversion to dementia from prodromal disease

    Hye, A. , Riddoch-Contreras, J. , Baird, A. L. , Ashton, N. , Bazenet, C. , Leung, R. , Westman, E. , Simmons, A. , Dobson, R. , Sattlecker, M. , Lupton, M. , Lunnon, K. , Keohane, A. , Ward, M. , Pike, I. , Zucht, H. D. , Pepin, D. , Zheng, W. , Tunnicliffe, A. , Richardson, J. & 7 others Gauthier, S., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B. & Lovestone, S. 1 Nov 2014 In : Alzheimer's & dementia : the journal of the Alzheimer's Association. 10, 6, p. 799–807.e2 11 p.

    Research output: Contribution to journalArticle

  38. Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

    Proitsi, P. , Lupton, M. K. , Velayudhan, L. , Newhouse, S. , Fogh, I. , Tsolaki, M. , Daniilidou, M. , Pritchard, M. , Kloszewska, I. , Soininen, H. , Mecocci, P. , Vellas, B. , Williams, J. , Harold, D. , Sims, R. , Gerrish, A. , Chapman, J. , Escott-Price, V. , Abraham, R. , Hollingworth, P. & 74 others Hamshere, M., Singh Pahwa, J., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A., Williams, K., Lovestone, S., Powell, J. F., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K., Passmore, P., Craig, D., Mcguinness, B., Johnston, J. A., Todd, S., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Guerreiro, R., Singleton, A., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Heun, R., Schürmann, B., Ramirez, A., Becker, T., Herold, C., Lacour, A., Drichel, D., Van Den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., Mcquillin, A., Gwilliam, R., Deloukas, P., Nöthen, M. M., Holmans, P., O'donovan, M., Owen, M. J., Williams, J., Stewart, R. & Sham, P. 16 Sep 2014 In : PLoS Medicine. 11, 9

    Research output: Contribution to journalArticle

  39. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

    Lunnon, K. , Smith, R. , Hannon, E. , De Jager, P. L. , Srivastava, G. , Volta, M. , Troakes, C. , Al-Sarraj, S. , Burrage, J. , Macdonald, R. , Condliffe, D. , Harries, L. W. , Katsel, P. , Haroutunian, V. , Kaminsky, Z. , Joachim, C. , Powell, J. , Lovestone, S. , Bennett, D. A. , Schalkwyk, L. C. & 1 others Mill, J. Sep 2014 In : Nature Neuroscience. 17, 9, p. 1164-1170 7 p.

    Research output: Contribution to journalArticle

  40. Circulating Proteomic Signatures of Chronological Age

    Menni, C. , Kiddle, S. J. , Mangino, M. , Viñuela, A. , Psatha, M. , Steves, C. , Sattlecker, M. , Buil, A. , Newhouse, S. , Nelson, S. , Williams, S. , Voyle, N. , Soininen, H. , Kloszewska, I. , Mecocci, P. , Tsolaki, M. , Vellas, B. , Lovestone, S. , Spector, T. D. , Dobson, R. & 1 others Valdes, A. M. 14 Aug 2014 In : The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 70, 7, p. 809-816 8 p.

    Research output: Contribution to journalArticle

  41. Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

    Condliffe, D., Wong, A., Troakes, C., Proitsi, P., Patel, Y., Chouliaras, L., Fernandes, C., Cooper, J., Lovestone, S., Schalkwyk, L., Mill, J. & Lunnon, K. Aug 2014 In : Neurobiology of Aging. 35, 8, p. 1850-1854 5 p.

    Research output: Contribution to journalArticle

  42. Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

    Escott-Price, V. , Bellenguez, C. , Wang, L-S. , Choi, S-H. , Harold, D. , Jones, L. , Holmans, P. , Gerrish, A. , Vedernikov, A. , Richards, A. , DeStefano, A. L. , Lambert, J-C. , Ibrahim-Verbaas, C. A. , Naj, A. C. , Sims, R. , Jun, G. , Bis, J. C. , Beecham, G. W. , Grenier-Boley, B. , Russo, G. & 31 others Thornton-Wells, T. A., Denning, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C-F., Schmidt, H., Kunkle, B., Dunstan, M. L., Vronskaya, M., Johnson, A. D., Ruiz, A., Bihoreau, M-T., Reitz, C., Pasquier, F., Hollingworth, P., Hanon, O., Fitzpatrick, A. L., Buxbaum, J. D., Campion, D., Crane, P. K., Baldwin, C., Becker, T., Lovestone, S., Proitsi, P., Powell, J. F. & United Kingdom Brain Expression 12 Jun 2014 In : PL o S One . 9, 6, 13 p., e94661

    Research output: Contribution to journalArticle

  43. Dynamin protein in stroke and vascular dementia

    Mulugeta, E., Vallortigara, J., Francis, P. T., Hye, A., Kalaria, R. N., Perry, E. K., Lovestone, S. & Ballard, C. G. 20 Mar 2014 In : Neuroscience Letters. 563, N/A, p. 118-122 5 p., N/A

    Research output: Contribution to journalArticle

  44. No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents

    Khan, W. , Giampietro, V. , Ginestet, C. , Dell' Acqua, F. , Bouls, D. , Newhouse, S. , Dobson, R. , Banaschewski, T. , Barker, G. J. , Bokde, A. L. W. , Büchel, C. , Conrod, P. , Flor, H. , Frouin, V. , Garavan, H. , Gowland, P. , Heinz, A. , Ittermann, B. , Lemaître, H. , Nees, F. & 10 others Paus, T., Pausova, Z., Rietschel, M., Smolka, M. N., Ströhle, A., Gallinat, J., Westman, E., Schumann, G., Lovestone, S. & Simmons, A. 1 Mar 2014 In : Journal of Alzheimer's disease : JAD. 40, 1, p. 37-43 7 p.

    Research output: Contribution to journalArticle

  45. Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

    Whiley, L., Sen, A., Heaton, J., Proitsi, P., Garcia-Gomez, D., Leung, R., Smith, N., Thambisetty, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S. & Legido Quigley, C. 1 Feb 2014 In : Neurobiology of Aging. 35, 2, p. 271-278 8 p.

    Research output: Contribution to journalArticle

  46. Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood

    Proitsi, P., Lee, S. H., Lunnon, K., Keohane, A., Powell, J., Troakes, C., Al-Sarraj, S., Furney, S., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A. & AddNeuroMed Consortium Feb 2014 In : Neurobiology of Aging. 35, 2, p. 279-290 12 p.

    Research output: Contribution to journalArticle

  47. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

    Killick, R. , Ribe, E. M. , Al-Shawi, R. , Malik, B. , Hooper, C. , Fernandes, C. , Dobson, R. , Nolan, P. M. , Lourdusamy, A. , Furney, S. , Lin, K. , Breen, G. , Wroe, R. , To, A. W. M. , Leroy, K. , Causevic, M. , Usardi, A. , Robinson, M. , Noble, W. , Williamson, R. & 9 others Lunnon, K., Kellie, S., Reynolds, C. H., Bazenet, C., Hodges, A., Brion, J-P., Stephenson, J., Paul Simons, J. & Lovestone, S. 1 Jan 2014 In : Molecular Psychiatry. 19, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  48. Developing novel blood-based biomarkers for Alzheimer's disease

    Snyder, H. M., Carrillo, M. C., Grodstein, F., Henriksen, K., Jeromin, A., Lovestone, S., Mielke, M. M., O'Bryant, S., Sarasa, M., Sjøgren, M., Soares, H., Teeling, J., Trushina, E., Ward, M., West, T., Bain, L. J., Shineman, D. W., Weiner, M. & Fillit, H. M. Jan 2014 In : Alzheimer's & Dementia. 10, 1, p. 109-114 6 p.

    Research output: Contribution to journalArticle

  49. Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort

    Aguilar, C., Muehlboeck, J-S., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., Lovestone, S., Wahlund, L-O., Simmons, A., Westman, E. & AddNeuroMed Consortium 2014 In : Frontiers in aging neuroscience. 6, 12 p., 145

    Research output: Contribution to journalArticle

  50. Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts

    Khan, W. . W., Westman, E., Jones, N., Wahlund, L-O., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Soininen, H., Spenger, C., Lovestone, S., Muehlboeck, J-S., Simmons, A. & for the AddNeuroMed consortium and for the Alzheimer’s Disease Neuroimaging Initiative 2014 In : Brain topography. 14 p.

    Research output: Contribution to journalArticle

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