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Research Outputs

  1. 2021
  2. Age-related changes in physiology in individuals with bipolar disorder

    Mutz, J., Young, A. & Lewis, C., 21 Sep 2021, In: Journal of affective disorders.

    Research output: Contribution to journalArticlepeer-review

  3. Methylome-wide association study of early life stressors and adult mental health

    Howard, D., Pain, O., Arathimos, R., Barbu, M. C., Amador, C., Walker, R. M., Jermy, B. S., Adams, M., Deary, I., Porteous, D. J., Campbell, A., Sullivan, P. F., Evans, K. L., Arseneault, L., Wray, N. R., Meaney, M. J., McIntosh, A. & Lewis, C., 13 Sep 2021, (Accepted/In press) In: Human Molecular Genetics.

    Research output: Contribution to journalArticlepeer-review

  4. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

    Martin, J., Asjadi, K., Hubbard, L., Kendall, K., Pardiñas, A. F., Jermy, B., Lewis, C. M., Baune, B. T., Boomsma, D. I., Hamilton, S. P., Lucae, S., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Mehta, D., Mors, O., Mullins, N., Penninx, B. W. J. H., Preisig, M., Rietschel, M. & 5 others, Jones, I., Walters, J. T. R., Rice, F., Thapar, A. & O'Donovan, M., Sep 2021, In: PLoS ONE. 16, 9 September, e0248254.

    Research output: Contribution to journalArticlepeer-review

  5. Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing

    Fabbri, C., Pain, O., Hagenaars, S. P., Lewis, C. M. & Serretti, A., Sep 2021, In: Neuropsychopharmacology. 46, 10, p. 1821-1829 9 p.

    Research output: Contribution to journalArticlepeer-review

  6. A Genome-Wide Association Study and Polygenic Risk Score Analysis of Posttraumatic Stress Disorder and Metabolic Syndrome in a South African Population

    Swart, P. C., van den Heuvel, L. L., Lewis, C. M., Seedat, S. & Hemmings, S. M. J., 10 Jun 2021, In: Frontiers in Neuroscience. 15, 677800.

    Research output: Contribution to journalArticlepeer-review

  7. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Jun 2021, In: Nature Genetics. 53, 6, p. 817-829 13 p.

    Research output: Contribution to journalArticlepeer-review

  8. Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

    Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group, National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network, UK DNA Lacunar Stroke Study Investigators & International Stroke Genetics Consortium, May 2021, In: The Lancet Neurology. 20, 5, p. 351-361 11 p.

    Research output: Contribution to journalArticlepeer-review

  9. The association between genetically determined ABO blood types and major depressive disorder

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, May 2021, In: Psychiatry Research. 299, 113837.

    Research output: Contribution to journalArticlepeer-review

  10. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, Blokland, G. A. M., Grove, J., Chen, C-Y., Cotsapas, C., Tobet, S., Handa, R., St Clair, D., Lencz, T., Mowry, B. J., Periyasamy, S., Cairns, M. J., Tooney, P. A., Wu, J. Q., Kelly, B., Kirov, G., Sullivan, P. F., Corvin, A., Riley, B. P., Esko, T. & 33 others, Milani, L., Jönsson, E. G., Palotie, A., Ehrenreich, H., Begemann, M., Steixner-Kumar, A., Sham, P. C., Iwata, N., Weinberger, D. R., Gejman, P. V., Sanders, A. R., Buxbaum, J. D., Rujescu, D., Giegling, I., Konte, B., Hartmann, A. M., Bramon, E., Murray, R. M., Pato, M. T., Lee, J., Melle, I., Molden, E., Ophoff, R. A., McQuillin, A., Bass, N. J., Adolfsson, R., Malhotra, A. K., Martin, N. G., Mullins, N., Breen, G., Lewis, C. M., Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Young, A., 23 Mar 2021, In: Biological psychiatry.

    Research output: Contribution to journalArticlepeer-review

  11. Associations and Limited Shared Genetic Etiology between Bipolar Disorder and Cardiometabolic Traits in the UK Biobank

    Furtjes, A., Hagenaars, S., Lewis, C., Coleman, J. & Tyrell, J., 2 Mar 2021, (Accepted/In press) In: Psychological Medicine.

    Research output: Contribution to journalArticlepeer-review

  12. Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

    Fabbri, C., Hagenaars, S., John, C., Williams, A., Shrine, N., Moles, L., Hanscombe, K., Serretti, A., Shepherd, D., Free, R., Wain, L., Tobin, M. & Lewis, C., 10 Feb 2021, (Accepted/In press) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  13. Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults

    Creese, B., Arathimos, R., Brooker, H., Aarsland, D., Corbett, A., Lewis, C., Ballard, C. & Ismail, Z., 16 Jan 2021, (Accepted/In press) In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring.

    Research output: Contribution to journalArticlepeer-review

  14. Cost-effectiveness of genetic and clinical predictors for choosing combined psychotherapy and pharmacotherapy in major depression

    Fabbri, C., Kasper, S., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P., Rujescu, D., Mendlewicz, J., Serretti, A. & Lewis, C. M., 15 Jan 2021, In: Journal of Affective Disorders. 279, p. 722-729 8 p.

    Research output: Contribution to journalArticlepeer-review

  15. Examining the association between family status and depression in the UK Biobank

    Giannelis, A., Palmos, A., Hagenaars, S. P., Breen, G., Lewis, C. M. & Mutz, J., 15 Jan 2021, In: Journal of Affective Disorders. 279, p. 585-598 14 p.

    Research output: Contribution to journalArticlepeer-review

  16. Exploring the genetic heterogeneity in major depression across diagnostic criteria

    Jermy, B. S., Glanville, K. P., Coleman, J. R. I., Lewis, C. M. & Vassos, E., 2021, (Accepted/In press) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  17. Genome-wide association study of suicidal behaviour severity in mood disorders

    Zai, C. C., Fabbri, C., Hosang, G. M., Zhang, R. S., Koyama, E., de Luca, V., Tiwari, A. K., King, N., Strauss, J., Jones, I., Jones, L., Breen, G., Farmer, A. E., McGuffin, P., Vincent, J. B., Kennedy, J. L. & Lewis, C. M., 2021, (Accepted/In press) In: World Journal of Biological Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  18. 2020
  19. Genetics and major depressive disorder: clinical implications for disease risk, prognosis and treatment

    Fabbri, C., Montgomery, S., Lewis, C. & Serretti, A., 1 Sep 2020, In: International Clinical Psychopharmacology. 35, 5, p. 233-242 10 p.

    Research output: Contribution to journalReview articlepeer-review

  20. Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke

    COMPASS, SiGN, and METASTROKE Consortia, 1 Aug 2020, In: Stroke. 51, 8, p. 2454-2463 10 p.

    Research output: Contribution to journalArticlepeer-review

  21. Drug repositioning for treatment-resistant depression: Hypotheses from a pharmacogenomic study

    Fabbri, C., Kasper, S., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P., Rujescu, D., Mendlewicz, J., De Ronchi, D., Riva, M. A., Lewis, C. & Serretti, A., 30 Jul 2020, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 104, 110050.

    Research output: Contribution to journalArticlepeer-review

  22. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

    Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 15 Jul 2020, In: Biological psychiatry. 88, 2, p. 169-184 16 p.

    Research output: Contribution to journalArticlepeer-review

  23. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    Coleman, J. R. I., Peyrot, W. J., Purves, K., Davis, K. A. S., Rayner, C., Choi, S. W., Huebel, C., Gaspar, H. A., Kan, C., der Auwera, S. V., Adams, M. J., Lyall, D., Choi, K. W., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dunn, E. C., Vassos, E., Danese, A., Maughan, B., Grabe, H. J., Lewis, C. M. & 8 others, O'Reilly, P. F., McIntosh, A. M., Smith, D. J., Wray, N. R., Hotopf, M., Eley, T., Breen, G. & Howard, D., 1 Jul 2020, In: Molecular Psychiatry. 25, 7, p. 1430-1446 17 p.

    Research output: Contribution to journalArticlepeer-review

  24. Genetic Associations between Childhood Psychopathology and Adult Depression and Associated Traits in 42998 Individuals: A Meta-Analysis

    Akingbuwa, W. A., Hammerschlag, A. R., Jami, E. S., Allegrini, A. G., Karhunen, V., Sallis, H., Ask, H., Askeland, R. B., Baselmans, B., Diemer, E., Hagenbeek, F. A., Havdahl, A., Hottenga, J. J., Mbarek, H., Rivadeneira, F., Tesli, M., Van Beijsterveldt, C., Breen, G., Lewis, C. M., Thapar, A. & 15 others, Boomsma, D. I., Kuja-Halkola, R., Reichborn-Kjennerud, T., Magnus, P., Rimfeld, K., Ystrom, E., Jarvelin, M. R., Lichtenstein, P., Lundstrom, S., Munafò, M. R., Plomin, R., Tiemeier, H., Nivard, M. G., Bartels, M. & Middeldorp, C. M., Jul 2020, In: JAMA Psychiatry. 77, 7, p. 715-728 14 p.

    Research output: Contribution to journalArticlepeer-review

  25. Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores

    Folkersen, L., Pain, O., Ingason, A., Werge, T., Lewis, C. M. & Austin, J., 30 Jun 2020, In: Frontiers in Genetics. 11, 578.

    Research output: Contribution to journalArticlepeer-review

  26. Genetic stratification of depression in UK Biobank

    Howard, D., Folkersen, L., Coleman, J., Adams, M., Glanville, K., Werge, T., Hagenaars, S., Han, B., Porteous, D., Campbell, A., Clarke, T-K., Breen, G., Sullivan, P. F., Wray, N. R., Lewis, C. & McIntosh, A., 24 May 2020, In: Translational psychiatry. 10, 1, 163.

    Research output: Contribution to journalArticlepeer-review

  27. Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 18 May 2020, In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  28. Polygenic risk scores: From research tools to clinical instruments

    Lewis, C. M. & Vassos, E., 18 May 2020, In: Genome medicine. 12, 1, 44.

    Research output: Contribution to journalReview articlepeer-review

  29. Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

    Persyn, E., Hanscombe, K. B., Howson, J. M. M., Lewis, C. M., Traylor, M. & Markus, H. S., 1 May 2020, In: Nature Communications. 11, 1, 12 p., 2175.

    Research output: Contribution to journalArticlepeer-review

  30. Minimal phenotyping yields genome-wide association signals of low specificity for major depression

    MDD Working Group of the Psychiatric Genomics Consortium, 1 Apr 2020, In: Nature Genetics. 52, 4, p. 437-447 11 p.

    Research output: Contribution to journalArticlepeer-review

  31. Johannesburg Cancer Study (JCS): contribution to knowledge and opportunities arising from 20 years of data collection in an African setting

    Chen, W. C., Singh, E., Muchengeti, M., Bradshaw, D., Mathew, C. G., Babb de Villiers, C., Lewis, C. M., Waterboer, T., Newton, R. & Sitas, F., Apr 2020, In: Cancer Epidemiology. 65, 101701.

    Research output: Contribution to journalArticlepeer-review

  32. The genetic basis of MRI markers of cerebral small vessel disease: a genome wide association study in 42,310 participants

    Persyn, E., Hanscombe, K., Howson, J., Lewis, C., Traylor, M. & Markus, H., 24 Mar 2020, (Accepted/In press) In: Nature Communications.

    Research output: Contribution to journalArticlepeer-review

  33. Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

    Glanville, K. P., Coleman, J. R. I., Hanscombe, K. B., Euesden, J., Choi, S. W., Purves, K., Breen, G., Air, T. M., Andlauer, T. M. F., Baune, B. T., Binder, E. B., Blackwood, D. H. R., Boomsma, D. I., Buttenschøn, H. N., Colodro-Conde, L., Dannlowski, U., Direk, N., Dunn, E. C., Forstner, A. J., de Geus, E. J. C. & 34 others, Grabe, H. J., Hamilton, S. P., Jones, I., Jones, L. A., Knowles, J. A., Kutalik, Z., Levinson, D. F., Lewis, G., Lind, P. A., Lucae, S., Lucae, S., Magnusson., P. K. E., McGuffin, P., McIntosh, A., Milaneschi, Y., Lewis, C. M., Mostafavi, S., Muller-Myhsok, B., Pedersen, N. L., Penninx, B. W., Potash, J. B., Preisig, M., Ripke, S., Shi, J., Shyn, S. I., Smoller, J. W., Streit, F., Sullivan, P. F., Tiemeier, H., Uher, R., der Auwera, S. V., Weissman, M. M., O'Reilly, P. F. & Lewis, C. M., 1 Mar 2020, In: Biological psychiatry. 87, 5, p. 419-430 12 p.

    Research output: Contribution to journalArticlepeer-review

  34. A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping

    Fabbri, C., Kasper, S., Kautzky, A., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P., Rujescu, D., Mendlewicz, J., Uher, R., Lewis, C. M. & Serretti, A., 3 Feb 2020, In: Translational psychiatry. 10, 1, 12 p., 50.

    Research output: Contribution to journalArticlepeer-review

  35. Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and controls

    Sami, M., Quattrone, D., Ferraro, L., Tripoli, G., Cascia, E. L., Gayer-Anderson, C., Selten, J. P., Arango, C., Bernardo, M., Tarricone, I., Tortelli, A., Gatto, G., Del Peschio, S., Del-Ben, C. M., Rutten, B. P., Jones, P. B., Van Os, J., De Haan, L., Morgan, C., Lewis, C. & 5 others, Bhattacharyya, S., Freeman, T. P., Lynskey, M., Murray, R. M. & Forti, M. D., 1 Jan 2020, (Accepted/In press) In: Psychological Medicine.

    Research output: Contribution to journalArticlepeer-review

  36. Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study

    Thygesen, J. H., Presman, A., Harju-Seppänen, J., Irizar, H., Jones, R., Kuchenbaecker, K., Lin, K., Alizadeh, B. Z., Austin-Zimmerman, I., Bartels-Velthuis, A., Bhat, A., Bruggeman, R., Cahn, W., Calafato, S., Crespo-Facorro, B., de Haan, L., de Zwarte, S. M. C., Di Forti, M., Díez-Revuelta, Á., Hall, J. & 37 others, Hall, M. H., Iyegbe, C., Jablensky, A., Kahn, R., Kalaydjieva, L., Kravariti, E., Lawrie, S., Luykx, J. J., Mata, I., McDonald, C., McIntosh, A. M., McQuillin, A., Muir, R., Ophoff, R., Picchioni, M., Prata, D. P., Ranlund, S., Rujescu, D., Rutten, B. P. F., Schulze, K., Shaikh, M., Schirmbeck, F., Simons, C. J. P., Toulopoulou, T., van Amelsvoort, T., van Haren, N., van Os, J., van Winkel, R., Vassos, E., Walshe, M., Weisbrod, M., Zartaloudi, E., Bell, V., Powell, J., Lewis, C. M., Murray, R. M. & Bramon, E., 1 Jan 2020, (Accepted/In press) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

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