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Research Outputs

  1. 2022
  2. Stratification of individuals with lifetime depression and low wellbeing in the UK Biobank

    Fabbri, C., Mutz, J., Lewis, C. M. & Serretti, A., 1 Oct 2022, In: Journal of Affective Disorders. 314, p. 281-292 12 p.

    Research output: Contribution to journalArticlepeer-review

  3. Clarifying the causes of consistent and inconsistent findings in genetics

    Dattani, S., Howard, D., Lewis, C. & Sham, P., Oct 2022, In: Genetic Epidemiology. 46, 7, p. 372-389 18 p.

    Research output: Contribution to journalReview articlepeer-review

  4. Anxiety disorders and age-related changes in physiology

    Mutz, J., Hoppen, T., Fabbri, C. & Lewis, C., 14 Sep 2022, In: British Journal of Psychiatry. 221, 3, p. 528-537 10 p.

    Research output: Contribution to journalArticlepeer-review

  5. Clinical, demographic, and genetic risk factors of treatment-attributed suicidality in >10,000 Australian adults taking antidepressants

    Campos, A. I., Byrne, E. M., Iorfino, F., Fabbri, C., Hickie, I. B., Lewis, C. M., Wray, N. R., Medland, S. E., Rentería, M. E. & Martin, N. G., Sep 2022, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 189, 6, p. 196-206 11 p.

    Research output: Contribution to journalArticlepeer-review

  6. Polygenic scores in biomedical research

    Kullo, I. J., Lewis, C. M., Inouye, M., Martin, A. R., Ripatti, S. & Chatterjee, N., Sep 2022, In: NATURE REVIEWS GENETICS. 23, 9, p. 524-532 9 p.

    Research output: Contribution to journalArticlepeer-review

  7. Exploring polygenic-environment and residual-environment interactions for depressive symptoms within the UK Biobank

    Gillett, A. C., Jermy, B. S., Lee, S. H., Pain, O., Howard, D. M., Hagenaars, S. P., Hanscombe, K. B., Coleman, J. R. I. & Lewis, C. M., 1 Jul 2022, In: Genetic Epidemiology. 46, 5-6, p. 219-233 15 p.

    Research output: Contribution to journalArticlepeer-review

  8. Lifestyle factors associated with sex differences in Kaposi sarcoma incidence among adult black South Africans: A case-control study

    Motlhale, M., Sitas, F., Bradshaw, D., Chen, W. C., Singini, M. G., de Villiers, C. B., Lewis, C. M., Muchengeti, M., Waterboer, T., Mathew, C. G., Newton, R. & Singh, E., 30 Jun 2022, In: Cancer Epidemiology. 78, 102158.

    Research output: Contribution to journalArticlepeer-review

  9. Epidemiology of Kaposi's sarcoma in sub-Saharan Africa

    Motlhale, M., Sitas, F., Bradshaw, D., Chen, W. C., Singini, M. G., de Villiers, C. B., Lewis, C. M., Muchengeti, M., Waterboer, T., Mathew, C. G., Newton, R. & Singh, E., Jun 2022, In: Cancer Epidemiology. 78, 102167.

    Research output: Contribution to journalReview articlepeer-review

  10. Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

    iPSYCH, Tourette Syndrome and Obsessive Compulsive Disorder Working Group of the Psychiatric Genetics Consortium, Bipolar Disorder Working Group of the Psychiatric Genetics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genetics Consortium & Schizophrenia Working Group of the Psychiatric Genetics Consortium, May 2022, In: Nature genetics. 54, 5, p. 548-559 12 p.

    Research output: Contribution to journalArticlepeer-review

  11. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M-H., Watson, H. J., Adams, M., Awasthi, S., Gandal, M., Hafferty, J. D., Hishimoto, A., Kim, M., & 33 othersOkazaki, S., Otsuka, I., Ripke, S., Ware, E. B., Bergen, A. W., Berrettini, W. H., Bohus, M., Brandt, H., Chang, X., Chen, W. J., Chen, H-C., Crawford, S., Crow, S., DiBlasi, E., Duriez, P., Fernández-Aranda, F., Fichter, M. M., Gallinger, S., Glatt, S. J., Gorwood, P., Guo, Y., Hakonarson, H., Halmi, K. A., Hwu, H-G., Jain, S., Jamain, S., Treasure, J., McGuffin, P., Power, R. A., Sonuga-Barke, E. J. S., Breen, G., Lewis, C. M. & Hübel, C., 1 Feb 2022, In: Biological psychiatry. 91, 3, p. 313-327 15 p.

    Research output: Contribution to journalArticlepeer-review

  12. Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia

    Vassos, E., Kou, J., Tosato, S., Maxwell, J., Dennison, C. A., Legge, S. E., Walters, J. T. R., Owen, M. J., O'Donovan, M. C., Breen, G., Lewis, C. M., Sullivan, P. F., Hultman, C., Ruggeri, M., Walshe, M., Bramon, E., Bergen, S. E. & Murray, R. M., 21 Jan 2022, In: Schizophrenia Bulletin. 48, 1, p. 20-26 7 p.

    Research output: Contribution to journalArticlepeer-review

  13. Age-related changes in physiology in individuals with bipolar disorder

    Mutz, J., Young, A. & Lewis, C., 1 Jan 2022, In: Journal of affective disorders. 296, p. 157-168 12 p.

    Research output: Contribution to journalArticlepeer-review

  14. 2021
  15. A Tool for Translating Polygenic Scores onto the Absolute Scale Using Summary Statistics

    Pain, O., Gillett, A., Austin, J., Folkersen, L. & Lewis, C., 9 Dec 2021, (Accepted/In press) In: European Journal of Human Genetics.

    Research output: Contribution to journalArticlepeer-review

  16. Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 3 Dec 2021, In: Frontiers in Psychiatry. 12, 734077.

    Research output: Contribution to journalArticlepeer-review

  17. Ranking lifestyle risk factors for cervical cancer among Black women: A case-control study from Johannesburg, South Africa

    Singini, M. G., Sitas, F., Bradshaw, D., Chen, W. C., Motlhale, M., Kamiza, A. B., De Villiers, C. B., Lewis, C. M., Mathew, C. G., Waterboer, T., Newton, R., Muchengeti, M. & Singh, E., Dec 2021, In: PLoS ONE. 16, 12 December, e0260319.

    Research output: Contribution to journalArticlepeer-review

  18. The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare

    Hanscombe, K. B., Persyn, E., Traylor, M., Glanville, K. P., Hamer, M., Coleman, J. R. I. & Lewis, C. M., Dec 2021, In: Genome medicine. 13, 1, 1 p., 180.

    Research output: Contribution to journalArticlepeer-review

  19. Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 2021, In: Neuropsychopharmacology. 46, 13, p. 2304-2311 8 p.

    Research output: Contribution to journalArticlepeer-review

  20. Cardiovascular health and risk of hospitalization with COVID-19: a Mendelian Randomization study

    Cecelja, M., Lewis, C. M., Shah, A. M. & Chowienczyk, P., 19 Nov 2021, (E-pub ahead of print) In: JRSM cardiovascular disease. 10

    Research output: Contribution to journalArticlepeer-review

  21. Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts

    Arathimos, R., Fabbri, C., Vassos, E., Davis, K., Pain, O., Gillett, A., Coleman, J., Hanscombe, K., Hagenaars, S., Jermy, B., Corbett, A., Ballard, C., Aarsland, D., Creese, B. & Lewis, C., 16 Nov 2021, (Accepted/In press) In: British Journal of Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  22. The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study

    Giannakopoulou, O., Lin, K., Meng, X., Su, M. H., Kuo, P. H., Peterson, R. E., Awasthi, S., Moscati, A., Coleman, J. R. I., Bass, N., Millwood, I. Y., Chen, Y., Chen, Z., Chen, H. C., Lu, M. L., Huang, M. C., Chen, C. H., Stahl, E. A., Loos, R. J. F., Mullins, N., & 17 othersUrsano, R. J., Kessler, R. C., Stein, M. B., Sen, S., Scott, L. J., Burmeister, M., Fang, Y., Tyrrell, J., Jiang, Y., Tian, C., McIntosh, A. M., Ripke, S., Dunn, E. C., Kendler, K. S., Walters, R. G., Lewis, C. M. & Kuchenbaecker, K., Nov 2021, In: JAMA Psychiatry. 78, 11, p. 1258-1269 12 p.

    Research output: Contribution to journalArticlepeer-review

  23. Methylome-wide association study of early life stressors and adult mental health

    Howard, D., Pain, O., Arathimos, R., Barbu, M. C., Amador, C., Walker, R. M., Jermy, B. S., Adams, M., Deary, I., Porteous, D. J., Campbell, A., Sullivan, P. F., Evans, K. L., Arseneault, L., Wray, N. R., Meaney, M. J., McIntosh, A. & Lewis, C., 15 Sep 2021, In: Human Molecular Genetics. 31, 4, p. 651–664

    Research output: Contribution to journalArticlepeer-review

  24. Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study

    Thygesen, J. H., Presman, A., Harju-seppänen, J., Irizar, H., Jones, R., Kuchenbaecker, K., Lin, K., Alizadeh, B. Z., Austin-zimmerman, I., Bartels-velthuis, A., Bhat, A., Bruggeman, R., Cahn, W., Calafato, S., Crespo-facorro, B., De Haan, L., De Zwarte, S. M. C., Di Forti, M., Díez-revuelta, Á., Hall, J., & 37 othersHall, M., Iyegbe, C., Jablensky, A., Kahn, R., Kalaydjieva, L., Kravariti, E., Lawrie, S., Luykx, J. J., Mata, I., Mcdonald, C., Mcintosh, A. M., Mcquillin, A., Muir, R., Ophoff, R., Picchioni, M., Prata, D. P., Ranlund, S., Rujescu, D., Rutten, B. P. F., Schulze, K., Shaikh, M., Schirmbeck, F., Simons, C. J. P., Toulopoulou, T., Van Amelsvoort, T., Van Haren, N., Van Os, J., Van Winkel, R., Vassos, E., Walshe, M., Weisbrod, M., Zartaloudi, E., Bell, V., Powell, J., Lewis, C. M., Murray, R. M. & Bramon, E., 1 Sep 2021, In: Molecular Psychiatry. 26, 9, p. 5307-5319

    Research output: Contribution to journalArticlepeer-review

  25. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

    Martin, J., Asjadi, K., Hubbard, L., Kendall, K., Pardiñas, A. F., Jermy, B., Lewis, C. M., Baune, B. T., Boomsma, D. I., Hamilton, S. P., Lucae, S., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Mehta, D., Mors, O., Mullins, N., Penninx, B. W. J. H., Preisig, M., Rietschel, M., & 5 othersJones, I., Walters, J. T. R., Rice, F., Thapar, A. & O'Donovan, M., Sep 2021, In: PLoS ONE. 16, 9 September, e0248254.

    Research output: Contribution to journalArticlepeer-review

  26. Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing

    Fabbri, C., Pain, O., Hagenaars, S. P., Lewis, C. M. & Serretti, A., Sep 2021, In: Neuropsychopharmacology. 46, 10, p. 1821-1829 9 p.

    Research output: Contribution to journalArticlepeer-review

  27. Exploring the genetic heterogeneity in major depression across diagnostic criteria

    Jermy, B. S., Glanville, K. P., Coleman, J. R. I., Lewis, C. M. & Vassos, E., 21 Jul 2021, (E-pub ahead of print) In: Molecular Psychiatry. 26, 12

    Research output: Contribution to journalArticlepeer-review

  28. A Genome-Wide Association Study and Polygenic Risk Score Analysis of Posttraumatic Stress Disorder and Metabolic Syndrome in a South African Population

    Swart, P. C., van den Heuvel, L. L., Lewis, C. M., Seedat, S. & Hemmings, S. M. J., 10 Jun 2021, In: Frontiers in Neuroscience. 15, 677800.

    Research output: Contribution to journalArticlepeer-review

  29. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Jun 2021, In: Nature Genetics. 53, 6, p. 817-829 13 p.

    Research output: Contribution to journalArticlepeer-review

  30. Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

    Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group, National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network, UK DNA Lacunar Stroke Study Investigators & International Stroke Genetics Consortium, May 2021, In: The Lancet Neurology. 20, 5, p. 351-361 11 p.

    Research output: Contribution to journalArticlepeer-review

  31. The association between genetically determined ABO blood types and major depressive disorder

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, May 2021, In: Psychiatry Research. 299, 113837.

    Research output: Contribution to journalArticlepeer-review

  32. Investigating pleiotropy between depression and autoimmune diseases using the UK Biobank

    Glanville, K., Coleman, J., O'Reilly, P. F., Galloway, J. & Lewis, C., 25 Mar 2021, (E-pub ahead of print) In: Biological Psychiatry: Global Open Science.

    Research output: Contribution to journalArticlepeer-review

  33. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, Blokland, G. A. M., Grove, J., Chen, C-Y., Cotsapas, C., Tobet, S., Handa, R., St Clair, D., Lencz, T., Mowry, B. J., Periyasamy, S., Cairns, M. J., Tooney, P. A., Wu, J. Q., Kelly, B., Kirov, G., Sullivan, P. F., Corvin, A., Riley, B. P., Esko, T., & 33 othersMilani, L., Jönsson, E. G., Palotie, A., Ehrenreich, H., Begemann, M., Steixner-Kumar, A., Sham, P. C., Iwata, N., Weinberger, D. R., Gejman, P. V., Sanders, A. R., Buxbaum, J. D., Rujescu, D., Giegling, I., Konte, B., Hartmann, A. M., Bramon, E., Murray, R. M., Pato, M. T., Lee, J., Melle, I., Molden, E., Ophoff, R. A., McQuillin, A., Bass, N. J., Adolfsson, R., Malhotra, A. K., Martin, N. G., Mullins, N., Breen, G., Lewis, C. M., Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Young, A., 23 Mar 2021, (E-pub ahead of print) In: Biological psychiatry.

    Research output: Contribution to journalArticlepeer-review

  34. Associations and Limited Shared Genetic Etiology between Bipolar Disorder and Cardiometabolic Traits in the UK Biobank

    Furtjes, A., Hagenaars, S., Lewis, C., Coleman, J. & Tyrell, J., 2 Mar 2021, (Accepted/In press) In: Psychological Medicine.

    Research output: Contribution to journalArticlepeer-review

  35. Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

    Fabbri, C., Hagenaars, S., John, C., Williams, A., Shrine, N., Moles, L., Hanscombe, K., Serretti, A., Shepherd, D., Free, R., Wain, L., Tobin, M. & Lewis, C., 10 Feb 2021, (Accepted/In press) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  36. Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults

    Creese, B., Arathimos, R., Brooker, H., Aarsland, D., Corbett, A., Lewis, C., Ballard, C. & Ismail, Z., 16 Jan 2021, (Accepted/In press) In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring.

    Research output: Contribution to journalArticlepeer-review

  37. Cost-effectiveness of genetic and clinical predictors for choosing combined psychotherapy and pharmacotherapy in major depression

    Fabbri, C., Kasper, S., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P., Rujescu, D., Mendlewicz, J., Serretti, A. & Lewis, C. M., 15 Jan 2021, In: Journal of Affective Disorders. 279, p. 722-729 8 p.

    Research output: Contribution to journalArticlepeer-review

  38. Examining the association between family status and depression in the UK Biobank

    Giannelis, A., Palmos, A., Hagenaars, S. P., Breen, G., Lewis, C. M. & Mutz, J., 15 Jan 2021, In: Journal of Affective Disorders. 279, p. 585-598 14 p.

    Research output: Contribution to journalArticlepeer-review

  39. Genome-wide association study of suicidal behaviour severity in mood disorders

    Zai, C. C., Fabbri, C., Hosang, G. M., Zhang, R. S., Koyama, E., de Luca, V., Tiwari, A. K., King, N., Strauss, J., Jones, I., Jones, L., Breen, G., Farmer, A. E., McGuffin, P., Vincent, J. B., Kennedy, J. L. & Lewis, C. M., 2021, In: World Journal of Biological Psychiatry. 22, 9, p. 722-731 10 p.

    Research output: Contribution to journalArticlepeer-review

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