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Research Outputs

  1. 2019
  2. Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

    Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

    Research output: Contribution to journalArticle

  3. The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity

    Selley, L., Phillips, D. H. & Mudway, I., 8 Jan 2019, In : Particle And Fibre Toxicology. 16, 1, 4.

    Research output: Contribution to journalReview article

  4. 2018
  5. Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust

    Rynning, I., Arlt, V. M., Vrbova, K., Neča, J., Rossner, P., Klema, J., Ulvestad, B., Petersen, E., Skare, Ø., Haugen, A., Phillips, D. H., Machala, M., Topinka, J. & Mollerup, S., 13 Nov 2018, In : Occupational & Environmental Medicine.

    Research output: Contribution to journalArticle

  6. Hepatic DNA damage in harbour porpoises (Phocoena phocoena) stranded along the English and Welsh coastlines

    Acevedo-Whitehouse, K., Cole, K. J., Phillips, D. H., Jepson, P. D., Deaville, R. & Arlt, V. M., Aug 2018, In : Environmental and Molecular Mutagenesis. 59, 7, p. 613-624

    Research output: Contribution to journalArticle

  7. Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolising activity of "luminal" muscle-invasive bladder cancers

    Baker, S. C., Arlt, V. M., Indra, R., Joel, M., Stiborova, M., Eardley, I., Ahmad, N., Otto, W., Burger, M., Rubenwolf, P., Phillips, D. H. & Southgate, J., May 2018, In : Molecular Carcinogenesis. 57, 5, p. 606-618

    Research output: Contribution to journalArticle

  8. Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

    Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In : Archives of Toxicology. 92, 4, p. 1625-1638

    Research output: Contribution to journalArticle

  9. EXPOsOMICS: Final policy workshop and stakeholder consultation David Stieb, Cecile Boot, Michelle Turner, Osmar Zaiane

    Turner, M. C., Vineis, P., Seleiro, E., Dijmarescu, M., Balshaw, D., Bertollini, R., Chadeau-Hyam, M., Gant, T., Gulliver, J., Jeong, A., Kyrtopoulos, S., Martuzzi, M., Miller, G. W., Nawrot, T., Nieuwenhuijsen, M., Phillips, D. H., Probst-Hensch, N., Samet, J., Vermeulen, R., Vlaanderen, J. & 3 othersVrijheid, M., Wild, C. & Kogevinas, M., 15 Feb 2018, In : BMC Public Health. 18, 1, 260.

    Research output: Contribution to journalArticle

  10. 2017
  11. Refinement of a Methodology for Untargeted Detection of Serum Albumin Adducts in Human Populations

    Preston, G. W. D., Plusquin, M., Sozeri, O., Van Veldhoven, K., Bastian, L., Nawrot, T. S., Chadeau-Hyam, M. & Phillips, D., 1 Nov 2017, In : Chemical Research in Toxicology. 30, 12, p. 2120-2129

    Research output: Contribution to journalArticle

  12. Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

    Arlt, V. M., Meinl, W., Florian, S., Nagy, E., Barta, F., Thomann, M., Mrizova, I., Krais, A. M., Liu, M., Richards, M., Mirza, A., Kopka, K., Phillips, D. H., Glatt, H., Stiborova, M. & Schmeiser, H. H., Apr 2017, In : Archives of Toxicology. 91, 4, p. 1957-1975

    Research output: Contribution to journalArticle

  13. Nutlin-3a selects for cells harbouring TP53 mutations

    Kucab, J. E., Hollstein, M., Arlt, V. M. & Phillips, D. H., 15 Feb 2017, In : International Journal of Cancer. 140, 4, p. 877-887 11 p.

    Research output: Contribution to journalArticle

  14. 2016
  15. From the exposome to mechanistic understanding of chemical-induced adverse effects

    Escher, B. I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S. K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J. J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J. & 16 othersKlüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G. W., Müller, A., Phillips, D. H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y-M., Trump, S., Walter-Rohde, S. & Wambaugh, J. F., 8 Dec 2016, In : Environment International.

    Research output: Contribution to journalArticle

  16. Mutational signatures associated with tobacco smoking in human cancer

    Alexandrov, L. B., Ju, Y. S., Haase, K., Van Loo, P., Martincorena, I., Nik-Zainal, S., Totoki, Y., Fujimoto, A., Nakagawa, H., Shibata, T., Campbell, P. J., Vineis, P., Phillips, D. H. & Stratton, M. R., 4 Nov 2016, In : Science. 354, 6312, p. 618-622 5 p.

    Research output: Contribution to journalArticle

  17. NADH:Cytochrome b5 reductase and cytochrome b5 can act as sole electron donors to human cytochrome P450 1A1-mediated oxidation and DNA adduct formation by benzo[a]pyrene

    Stiborova, M., Indra, R., Moserova, M., Frei, E., Schmeiser, H. H., Kopka, K., Phillips, D. H. & Arlt, V. M., 15 Aug 2016, In : Chemical Research in Toxicology. 29, 8, p. 1325-1334

    Research output: Contribution to journalArticle

  18. Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene

    Chepelev, N. L., Long, A. S., Bowers, W. J., Gagné, R., Williams, A., Kuo, B., Phillips, D. H., Arlt, V. M., White, P. A. & Yauk, C. L., Jun 2016, In : Environmental and Molecular Mutagenesis. 57, 5, p. 350–363

    Research output: Contribution to journalArticle

  19. The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

    Krais, A. M., Speksnijder, E. N., Melis, J. P. M., Indra, R., Moserova, M., Godschalk, R. W., van Schooten, F-J., Seidel, A., Kopka, K., Schmeiser, H. H., Stiborova, M., Phillips, D. H., Luijten, M. & Arlt, V. M., 1 Apr 2016, In : Archives of Toxicology. 90, 4, p. 839-851 13 p.

    Research output: Contribution to journalArticle

  20. Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

    Wohak, L., Krais, A. M., Kucab, J. E., Stertmann, J., Ovrebø, S., Seidel, A., Phillips, D. H. & Arlt, V. M., 1 Feb 2016, In : Archives of Toxicology. 90, 2, p. 291-304 14 p.

    Research output: Contribution to journalArticle

  21. Metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and DNA adduct formation depends on p53: studies in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

    Krais, A. M., Speksnijder, E. N., Melis, J. P. M., Singh, R., Caldwell, A., Gamboa da Costa, G., Luijten, M., Phillips, D. H. & Arlt, V. M., Feb 2016, In : International Journal of Cancer. 138, 4, p. 976–982

    Research output: Contribution to journalArticle

  22. Transcriptional profiling of dibenzo[def, p]chrysene-induced spleen atrophy provides mechanistic insights into its immunotoxicity in mutamouse

    Chepelev, N. L., Long, A. S., Williams, A., Kuo, B., Gagné, R., Kennedy, D. A., Phillips, D. H., Arlt, V. M., White, P. A. & Yauk, C. L., 1 Jan 2016, In : Toxicological Sciences. 149, 1, p. 251-268 18 p.

    Research output: Contribution to journalArticle

  23. 2015
  24. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

    Kucab, J. E., Zwart, E. P., van Steeg, H., Luijten, M., Schmeiser, H. H., Phillips, D. H. & Arlt, V. M., 8 Dec 2015, In : DNA REPAIR.

    Research output: Contribution to journalArticle

  25. The genome as a record of environmental exposure

    Nik-Zainal, S., Kucab, J. E., Morganella, S., Glodzik, D., Alexandrov, L. B., Arlt, V. M., Weninger, A., Hollstein, M., Stratton, M. R. & Phillips, D. H., Nov 2015, In : Mutagenesis. 30, 6, p. 763-770 8 p.

    Research output: Contribution to journalArticle

  26. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development

    Perera, F., Phillips, D. H., Wang, Y., Roen, E., Herbstman, J., Rauh, V., Wang, S. & Tang, D., 21 Aug 2015, In : Environmental Research. 142, p. 602-608 7 p., 6575.

    Research output: Contribution to journalArticle

  27. The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Stiborova, M. & Phillips, D. H., 1 May 2015, In : Toxicology Research. 4, 3, p. 548-562 15 p.

    Research output: Contribution to journalLiterature review

  28. Pulmonary inflammation impacts on CYP1A1-mediated respiratory tract DNA damage induced by the carcinogenic air pollutant benzo[a]pyrene

    Arlt, V. M., Krais, A., Godschalk, R. W., Riffo-Vasquez, Y., Mrizova, I., Roufosse, C. A., Corbin, C., Shi, Q., Frei, E., Stiborova, M., van Schooten, F-J., Phillips, D. H. & Spina, D., 23 Apr 2015, In : Toxicological sciences : an official journal of the Society of Toxicology. 146, 2, p. 213-225 13 p.

    Research output: Contribution to journalArticle

  29. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

    Kucab, J. E., van Steeg, H., Luijten, M., Schmeiser, H. H., White, P. A., Phillips, D. H. & Arlt, V. M., 1 Mar 2015, In : Mutation Research. 773, p. 48-62 15 p.

    Research output: Contribution to journalArticle

  30. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

    Krais, A. M., Mühlbauer, K-R., Kucab, J. E., Chinbuah, H., Cornelius, M. G., Wei, Q-X., Hollstein, M., Phillips, D. H., Arlt, V. M. & Schmeiser, H. H., Feb 2015, In : Toxicology in Vitro. 29, 1, p. 34-43 10 p.

    Research output: Contribution to journalArticle

  31. 2014
  32. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

    Zuo, J., Brewer, D. S., Arlt, V. M., Cooper, C. S. & Phillips, D. H., 8 Oct 2014, In : BMC GENOMICS. 15, 20 p., 880.

    Research output: Contribution to journalArticle

  33. Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

    Schmeiser, H. H., Nortier, J. L., Singh, R., da Costa, G. G., Sennesael, J., Cassuto-Viguier, E., Ambrosetti, D., Rorive, S., Pozdzik, A., Phillips, D. H., Stiborova, M. & Arlt, V. M., 15 Jul 2014, In : International Journal of Cancer. 135, 2, p. 502-507 6 p.

    Research output: Contribution to journalArticle

  34. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories

    Godschalk, R. W. L., Ersson, C., Stępnik, M., Ferliłska, M., Palus, J., Teixeira, J. P., Costa, S., Jones, G. D. D., Higgins, J. A., Kain, J., Möller, L., Forchhammer, L., Loft, S., Lorenzo, Y., Collins, A. R., van Schooten, F-J., Laffon, B., Valdiglesias, V., Cooke, M., Mistry, V. & 12 othersKarbaschi, M., Phillips, D. H., Sozeri, O., Routledge, M. N., Nelson-Smith, K., Riso, P., Porrini, M., López de Cerain, A., Azqueta, A., Matullo, G., Allione, A. & Møller, P., Jul 2014, In : Mutagenesis. 29, 4, p. 241-249 9 p.

    Research output: Contribution to journalArticle

  35. MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases

    Nagy, E., Gajjar, K. B., Patel, I. I., Taylor, S., Martin-Hirsch, P. L., Stringfellow, H. F., Martin, F. L. & Phillips, D. H., 10 Jun 2014, In : BJC: British Journal of Cancer. 110, 12, p. 2874-2880 7 p.

    Research output: Contribution to journalArticle

  36. Cytochronne b(5) and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

    Stiborová, M., Moserová, M., Cerná, V., Indra, R., Dračínský, M., Sulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M., 6 Apr 2014, In : Toxicology. 318, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  37. Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway

    Dendelé, B., Tekpli, X., Hardonnière, K., Holme, J. A., Debure, L., Catheline, D., Arlt, V. M., Nagy, E., Phillips, D. H., Ovrebø, S., Mollerup, S., Poët, M., Chevanne, M., Rioux, V., Dimanche-Boitrel, M-T., Sergent, O. & Lagadic-Gossmann, D., 25 Jan 2014, In : Chemico-Biological Interactions. 207, N/A, p. 41-51 11 p., N/A.

    Research output: Contribution to journalArticle

  38. (32)P-postlabeling analysis of DNA adducts

    Phillips, D. H. & Arlt, V. M., 2014, Molecular Toxicology Protocols. Keohavong, P. & Grant, S. G. (eds.). 2nd ed. Totowa, N.J.: Humana Press, p. 127-138 12 p. (Methods in Molecular Biology; vol. 1105).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  39. 2013
  40. The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes

    Molina, E., Pérez-Morales, R., Rubio, J., Petrosyan, P., Cadena, L. H., Arlt, V. M., Phillips, D. H. & Gonsebatt, M. E., 12 Dec 2013, In : Mutation Research. 758, 1-2, p. 62-68 7 p., N/A.

    Research output: Contribution to journalArticle

  41. Molecular and metabolic consequences following E6 transfection in an isogenic ovarian cell line (A2780) pair

    Chung, Y-L., Nagy, E., Zietkowski, D., Payne, G. S., Phillips, D. H. & deSouza, N. M., Dec 2013, In : Cellular Physiology and Biochemistry. 32, 5, p. 1460-1472 13 p.

    Research output: Contribution to journalArticle

  42. DNA-repair measurements by use of the modified comet assay: an inter-laboratory comparison within the European Comet Assay Validation Group (ECVAG)

    Godschalk, R. W. L., Ersson, C., Riso, P., Porrini, M., Langie, S. A. S., van Schooten, F-J., Azqueta, A., Collins, A. R., Jones, G. D. D., Kwok, R. W. L., Phillips, D. H., Sozeri, O., Allione, A., Matullo, G., Möller, L., Forchhammer, L., Loft, S. & Møller, P., 18 Sep 2013, In : Mutation Research. 757, 1, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  43. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene

    Malik, A. I., Rowan-Carroll, A., Williams, A., Lemieux, C. L., Long, A. S., Arlt, V. M., Phillips, D. H., White, P. A. & Yauk, C. L., Sep 2013, In : Mutagenesis. 28, 5, p. 543-54 12 p.

    Research output: Contribution to journalArticle

  44. On the origins and development of the (32)P-postlabelling assay for carcinogen-DNA adducts

    Phillips, D. H., 28 Jun 2013, In : Cancer Letters. 334, 1, p. 5-9 5 p.

    Research output: Contribution to journalArticle

  45. Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype

    Etemadi, A., Islami, F., Phillips, D. H., Godschalk, R., Golozar, A., Kamangar, F., Malekshah, A. F-T., Pourshams, A., Elahi, S., Ghojaghi, F., Strickland, P. T., Taylor, P. R., Boffetta, P., Abnet, C. C., Dawsey, S. M., Malekzadeh, R. & van Schooten, F. J., 15 Jun 2013, In : International Journal of Cancer. 132, 12, p. 2738-2747 10 p.

    Research output: Contribution to journalArticle

  46. An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells

    Ersson, C., Møller, P., Forchhammer, L., Loft, S., Azqueta, A., Godschalk, R. W. L., van Schooten, F-J., Jones, G. D. D., Higgins, J. A., Cooke, M. S., Mistry, V., Karbaschi, M., Phillips, D. H., Sozeri, O., Routledge, M. N., Nelson-Smith, K., Riso, P., Porrini, M., Matullo, G., Allione, A. & 10 othersStepnik, M., Ferlińska, M., Teixeira, J. P., Costa, S., Corcuera, L-A., López de Cerain, A., Laffon, B., Valdiglesias, V., Collins, A. R. & Möller, L., May 2013, In : Mutagenesis. 28, 3, p. 279-286 8 p.

    Research output: Contribution to journalArticle

  47. The epidemiology, diagnosis, and management of aristolochic Acid nephropathy: a narrative review

    Gökmen, M. R., Cosyns, J-P., Arlt, V. M., Stiborová, M., Phillips, D. H., Schmeiser, H. H., Simmonds, M. S. J., Cook, H. T., Vanherweghem, J-L., Nortier, J. L. & Lord, G. M., 19 Mar 2013, In : Annals of Internal Medicine. 158, 6, p. 469-477 9 p.

    Research output: Contribution to journalReview article

  48. 2012
  49. DNA and protein adducts in human tissues resulting from exposure to tobacco smoke

    Phillips, D. H. & Venitt, S., 15 Dec 2012, In : International Journal of Cancer. 131, 12, p. 2733-2753 21 p.

    Research output: Contribution to journalArticle

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