King's College London

Research portal

Research Outputs

  1. 2022
  2. Wavefront Shaping-Assisted Forward-Viewing Photoacoustic Endomicroscopy Based on a Transparent Ultrasound Sensor

    Zhao, T., Zhang, M., Ourselin, S. & Xia, W., 9 Dec 2022, In: Applied Sciences (Switzerland). 12, 10 p., 12619.

    Research output: Contribution to journalArticlepeer-review

  3. App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden

    Kennedy, B., Fitipaldi, H., Hammar, U., Maziarz, M., Tsereteli, N., Oskolkov, N., Varotsis, G., Franks, C. A., Nguyen, D., Spiliopoulos, L., Adami, H. O., Björk, J., Engblom, S., Fall, K., Grimby-Ekman, A., Litton, J. E., Martinell, M., Oudin, A., Sjöström, T., Timpka, T., & 16 othersSudre, C. H., Graham, M. S., du Cadet, J. L., Chan, A. T., Davies, R., Ganesh, S., May, A., Ourselin, S., Pujol, J. C., Selvachandran, S., Wolf, J., Spector, T. D., Steves, C. J., Gomez, M. F., Franks, P. W. & Fall, T., Dec 2022, In: Nature Communications. 13, 1, 2110.

    Research output: Contribution to journalArticlepeer-review

  4. Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom

    COPE Consortium, Dec 2022, In: Nature Communications. 13, 1, p. 636 1 p., 636.

    Research output: Contribution to journalArticlepeer-review

  5. Intraoperative Needle Tip Tracking with an Integrated Fibre-Optic Ultrasound Sensor

    Baker, C., Xochicale, M., Lin, F-Y., Mathews, S., Joubert, F., Shakir, D., Miles, R., Mosse, C. A., Zhao, T., Liang, W., Kunpalin, Y., Dromey, B. P., Mistry, T., Sebire, N. J., Zhang, E. Z., Ourselin, S., Beard, P., David, A., Desjardins, A. E., Vercauteren, T., & 1 othersXia, W., 22 Nov 2022, In: Sensors (Switzerland). 22, 23, 9035.

    Research output: Contribution to journalArticlepeer-review

  6. Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy

    Flouri, D., Darby, J. R. T., Holman, S. L., Cho, S. K. S., Dimasi, C. G., Perumal, S. R., Ourselin, S., Aughwane, R., Mufti, N., Macgowan, C. K., Seed, M., David, A. L., Melbourne, A. & Morrison, J. L., 25 Oct 2022, In: Advanced Science. 9, 30, p. e2203738 2203738.

    Research output: Contribution to journalArticlepeer-review

  7. Idea, Development, Exploration, Assessment, Long-term follow-up study (IDEAL) Stage 1/2a evaluation of urological procedures with the Versius robot

    Reeves, F., Challacombe, B., Ribbits, A., Ourselin, S. & Dasgupta, P., Oct 2022, In: BJU International. 130, 4, p. 441-443 3 p.

    Research output: Contribution to journalComment/debatepeer-review

  8. Brain Lesion Synthesis via Progressive Adversarial Variational Auto-Encoder

    Huo, J., Vakharia, V., Wu, C., Sharan, A., Ko, A. L., Ourselin, S. & Sparks, R., 18 Sep 2022, SASHIMI: International Workshop on Simulation and Synthesis in Medical Imaging. Springer, Cham, p. 101-111 11 p.

    Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

  9. Driving Points Prediction For Abdominal Probabilistic Registration

    Joutard, S., Dorent, R., Ourselin, S., Vercauteren, T. & Modat, M., 18 Sep 2022, Machine Learning in Medical Imaging: 13th International Workshop, MLMI 2022, Held in Conjunction with MICCAI 2022, Singapore, September 18, 2022, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

  10. Intra-operative OCT (iOCT) Super Resolution: A Two-Stage Methodology Leveraging High Quality Pre-operative OCT Scans

    Komninos, C., Pissas, T., Flores, B., Bloch, E., Vercauteren, T., Ourselin, S., Cruz, L. D. & Bergeles, C., 15 Sep 2022, International Workshop on Ophthalmic Medical Image Analysis: OMIA 2022: Ophthalmic Medical Image Analysis. Antony, B., Fu, H., Lee, C. S., MacGillivray, T., Xu, Y. & Zheng, Y. (eds.). Springer, Cham, Vol. 13576. p. 105-114 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 13576 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

  11. Individual Factors Including Age, BMI, and Heritable Factors Underlie Temperature Variation in Sickness and in Health: An Observational, Multi-cohort Study

    GSTT Covid Collaborative , Penfold, R. S., Zazzara, M. B., Österdahl, M. F., Welch, C., Ni Lochlainn, M., Freidin, M. B., Bowyer, R. C. E., Thompson, E. J., Antonelli, M., Tan, Y. X. R., Sudre, C. H., Modat, M., Murray, B., Wolf, J., Ourselin, S., Veenith, T., Lord, J. M. & Steves, C. J., Sep 2022, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 77, 9, p. 1890-1897 8 p.

    Research output: Contribution to journalArticlepeer-review

  12. The mental health burden of racial and ethnic minorities during the COVID-19 pandemic

    Nguyen, L. H., Anyane-Yeboa, A., Klaser, K., Merino, J., Drew, D. A., Ma, W., Mehta, R. S., Kim, D. Y., Warner, E. T., Joshi, A. D., Graham, M. S., Sudre, C. H., Thompson, E. J., May, A., Hu, C., Jørgensen, S., Selvachandran, S., Berry, S. E., David, S. P., Martinez, M. E., & 9 othersFigueiredo, J. C., Murray, A. M., Sanders, A. R., Koenen, K. C., Wolf, J., Ourselin, S., Spector, T. D., Steves, C. J. & Chan, A. T., Aug 2022, In: PLoS ONE. 17, 8 August, p. e0271661 e0271661.

    Research output: Contribution to journalArticlepeer-review

  13. Unsupervised Brain Imaging 3D Anomaly Detection and Segmentation with Transformers

    Pinaya, W. H. L., Tudosiu, P-D., Gray, R., Rees, G., Nachev, P., Ourselin, S. & Cardoso, M. J., 31 Jul 2022, In: Medical Image Analysis. 79, 102475.

    Research output: Contribution to journalArticlepeer-review

  14. Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease

    Sudre, C. H., Moriconi, S., Rehwald, R., Smith, L., Tillin, T., Barnes, J., Atkinson, D., Ourselin, S., Chaturvedi, N., Hughes, A. D., Jäger, H. R. & Cardoso, M. J., 28 Jul 2022, In: Frontiers in Cardiovascular Medicine. 9, 939680.

    Research output: Contribution to journalArticlepeer-review

  15. Ultrathin, high-speed, all-optical photoacoustic endomicroscopy probe for guiding minimally invasive surgery

    Zhao, T., Pham, T., Baker, C., Ma, M., Ourselin, S., Vercauteren, T., Zhang, E. Z., Beard, P. C. & Xia, W., 27 Jul 2022, In: Biomedical Optics Express. 13, 8, p. 4414-4428 15 p.

    Research output: Contribution to journalArticlepeer-review

  16. Cutaneous Manifestations of SARS-CoV-2 infection during the Delta and Omicron waves in 348,691 UK users of the UK ZOE COVID Study App

    Visconti, A., Murray, B., Rossi, N., Wolf, J., Ourselin, S., Spector, T. D., Freeman, E. E., Bataille, V. & Falchi, M., 22 Jul 2022, (E-pub ahead of print) In: The British journal of dermatology.

    Research output: Contribution to journalArticlepeer-review

  17. Distributionally Robust Deep Learning using Hardness Weighted Sampling

    Fidon, L., Aertsen, M., Deprest, T., Emam, D., Guffens, F., Mufti, N., Elslander, E. V., Schwartz, E., Ebner, M., Prayer, D., Kasprian, G., David, A. L., Melbourne, A., Ourselin, S., Deprest, J., Langs, G. & Vercauteren, T., 18 Jul 2022, In: MELBA (The Journal of Machine Learning for Biomedical Imaging). PIPPI 2021 special issue

    Research output: Contribution to journalArticlepeer-review

  18. Motion correction and volumetric reconstruction for fetal functional magnetic resonance imaging data

    Sobotka, D., Ebner, M., Schwartz, E., Nenning, K. H., Taymourtash, A., Vercauteren, T., Ourselin, S., Kasprian, G., Prayer, D., Langs, G. & Licandro, R., 15 Jul 2022, In: NeuroImage. 255, 119213.

    Research output: Contribution to journalArticlepeer-review

  19. The Medical Segmentation Decathlon

    Antonelli, M., Reinke, A., Bakas, S., Farahani, K., Kopp-Schneider, A., Landman, B. A., Litjens, G., Menze, B., Ronneberger, O., Summers, R. M., van Ginneken, B., Bilello, M., Bilic, P., Christ, P. F., Do, R. K. G., Gollub, M. J., Heckers, S. H., Huisman, H., Jarnagin, W. R., McHugo, M. K., & 38 othersNapel, S., Pernicka, J. S. G., Rhode, K., Tobon-Gomez, C., Vorontsov, E., Meakin, J. A., Ourselin, S., Wiesenfarth, M., Arbeláez, P., Bae, B., Chen, S., Daza, L., Feng, J., He, B., Isensee, F., Ji, Y., Jia, F., Kim, I., Maier-Hein, K., Merhof, D., Pai, A., Park, B., Perslev, M., Rezaiifar, R., Rippel, O., Sarasua, I., Shen, W., Son, J., Wachinger, C., Wang, L., Wang, Y., Xia, Y., Xu, D., Xu, Z., Zheng, Y., Simpson, A. L., Maier-Hein, L. & Cardoso, M. J., 15 Jul 2022, In: Nature Communications. 13, 1, p. 4128 4128.

    Research output: Contribution to journalArticlepeer-review

  20. COVID-19 vaccine waning and effectiveness and side effects of boosters: a prospective community study from the ZOE COVID Study

    Menni, C., May, A., Polidori, L., Louca, P., Wolf, J., Capdevila, J., Hu, C., Ourselin, S., Steves, C., Valdes, A. M. & Spector, T., Jul 2022, In: Lancet Infectious Diseases. 22, 7, p. 1002-1010 9 p.

    Research output: Contribution to journalArticlepeer-review

  21. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

    COVID-19 Genomics U. K. (COG-UK) Consortium, 28 Jun 2022, In: Scientific Reports. 12, 1, p. 10904 10904.

    Research output: Contribution to journalArticlepeer-review

  22. Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2

    Antonelli, M., Pujol, J. C., Spector, T. D., Ourselin, S. & Steves, C. J., 18 Jun 2022, In: The Lancet. 399, 10343, p. 2263-2264 2 p.

    Research output: Contribution to journalLetterpeer-review

  23. Fast Unsupervised Brain Anomaly Detection and Segmentation with Diffusion Models

    Pinaya, W. H. L., Graham, M. S., Gray, R., Costa, P. F. D., Tudosiu, P-D., Wright, P., Mah, Y. H., MacKinnon, A. D., Teo, J. T., Jager, R., Werring, D., Rees, G., Nachev, P., Ourselin, S. & Cardoso, M. J., 7 Jun 2022.

    Research output: Working paper/PreprintPreprint

  24. Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia

    GENetic Frontotemporal dementia Initiative (GENFI) , 1 Jun 2022, In: Neurobiology of Aging. 114, p. 94-104 11 p.

    Research output: Contribution to journalArticlepeer-review

  25. Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners

    Lazaridis, G., Montesano, G., Afgeh, S. S., Mohamed-Noriega, J., Ourselin, S., Lorenzi, M. & Garway-Heath, D. F., Jun 2022, In: American journal of ophthalmology. 238, p. 52-65 14 p.

    Research output: Contribution to journalArticlepeer-review

  26. Transformer-based out-of-distribution detection for clinically safe segmentation

    Graham, M. S., Tudosiu, P-D., Wright, P., Pinaya, W. H. L., Jean-Marie, U., Mah, Y., Teo, J., Jäger, R. H., Werring, D., Nachev, P., Ourselin, S. & Cardoso, M. J., 21 May 2022.

    Research output: Working paper/PreprintPreprint

  27. Deep forecasting of translational impact in medical research

    Nelson, A. P. K., Gray, R. J., Ruffle, J. K., Watkins, H. C., Herron, D., Sorros, N., Mikhailov, D., Cardoso, M. J., Ourselin, S., McNally, N., Williams, B., Rees, G. E. & Nachev, P., 13 May 2022, In: Patterns. 3, 5, 100483.

    Research output: Contribution to journalArticlepeer-review

  28. Illness characteristics of COVID-19 in children infected with the SARS-CoV-2 Delta variant

    Molteni, E., Sudre, C. H., Dos Santos Canas, L., Bhopal, S. S., Hughes, R. C., Chen, L., Deng, J., Murray, B., Kerfoot, E., Antonelli, M., Graham, M., Klaser, K., May, A., Hu, C., Pujol, J. C., Wolf, J., Hammers, A., Spector, T., Ourselin, S., Modat, M., & 3 othersSteves, CJ., Absoud, M. & Duncan, E., 3 May 2022, In: Children (Basel, Switzerland). 9, 5, 652.

    Research output: Contribution to journalArticlepeer-review

  29. Advanced quantitative evaluation of PET systems using the ACR phantom and NiftyPET software

    Markiewicz, P. J., da Costa-Luis, C., Dickson, J., Barnes, A., Krokos, G., MacKewn, J., Clark, T., Wimberley, C., MacNaught, G., Yaqub, M. M., Gispert, J. D., Hutton, B. F., Marsden, P., Hammers, A., Reader, A. J., Ourselin, S., Herholz, K., Matthews, J. C. & Barkhof, F., May 2022, In: Medical Physics. 49, 5, p. 3298-3313 16 p.

    Research output: Contribution to journalArticlepeer-review

  30. Deep learning models for triaging hospital head MRI examinations

    Wood, D. A., Kafiabadi, S., Busaidi, A. A., Guilhem, E., Montvila, A., Lynch, J., Townend, M., Agarwal, S., Mazumder, A., Barker, G. J., Ourselin, S., Cole, J. H. & Booth, T. C., May 2022, In: Medical Image Analysis. 78, p. 102391 102391.

    Research output: Contribution to journalArticlepeer-review

  31. Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study

    ISARIC-4C , 27 Apr 2022, In: Scientific Reports. 12, 1, p. 6843 1 p.

    Research output: Contribution to journalArticlepeer-review

  32. Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study

    Menni, C., Valdes, A. M., Polidori, L., Antonelli, M., Penamakuri, S., Nogal, A., Louca, P., May, A., Figueiredo, J. C., Hu, C., Molteni, E., Canas, L., Österdahl, M. F., Modat, M., Sudre, C. H., Fox, B., Hammers, A., Wolf, J., Capdevila, J., Chan, A. T., & 4 othersDavid, S. P., Steves, C. J., Ourselin, S. & Spector, T. D., 23 Apr 2022, In: Lancet. 399, 10335, p. 1618-1624 7 p.

    Research output: Contribution to journalArticlepeer-review

  33. A Dempster-Shafer approach to trustworthy AI with application to fetal brain MRI segmentation

    Fidon, L., Aertsen, M., Kofler, F., Bink, A., David, A. L., Deprest, T., Emam, D., Guffens, F., Jakab, A., Kasprian, G., Kienast, P., Melbourne, A., Menze, B., Mufti, N., Pogledic, I., Prayer, D., Stuempflen, M., Elslander, E. V., Ourselin, S., Deprest, J., & 1 othersVercauteren, T., 5 Apr 2022.

    Research output: Working paper/PreprintPreprint

  34. From Accuracy to Reliability and Robustness in Cardiac Magnetic Resonance Image Segmentation: A Review

    Galati, F., Ourselin, S. & Zuluaga, M. A., 1 Apr 2022, In: Applied Sciences (Switzerland). 12, 8, 3936.

    Research output: Contribution to journalArticlepeer-review

  35. Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near-infrared window

    Shapey, J., Xie, Y., Nabavi, E., Ebner, M., Saeed, S. R., Kitchen, N., Dorward, N., Grieve, J., McEvoy, A. W., Miserocchi, A., Grover, P., Bradford, R., Lim, Y-M., Ourselin, S., Brandner, S., Jaunmuktane, Z. & Vercauteren, T., Apr 2022, In: Journal of biophotonics. 15, 4, e202100072.

    Research output: Contribution to journalArticlepeer-review

  36. Neuroprotection is improved by watertightness of fetal spina bifida repair in fetal lamb

    Joyeux, L., van der Merwe, J., Aertsen, M., Patel, P. A., Khatoun, A., Mori da Cunha, M. G. M. C., De Vleeschauwer, S., Parra, J., Danzer, E., McLaughlin, M., Stoyanov, D., Vercauteren, T., Ourselin, S., Radaelli, E., de Coppi, P., Van Calenbergh, F. & Deprest, J., 30 Mar 2022, (E-pub ahead of print) In: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

    Research output: Contribution to journalArticlepeer-review

  37. Surgical Biomicroscopy Guided Intra-operative Optical Coherence Tomography (iOCT) Image Super Resolution

    Komninos, C., Pissas, T., Mekki, L., Flores, B., Bloch, E., Vercauteren, T., Ourselin, S., Da Cruz, L. & Bergeles, C., 9 Mar 2022, (Accepted/In press) In: International Journal of Computer Assisted Radiology and Surgery. p. 1 13 p.

    Research output: Contribution to journalArticlepeer-review

  38. AI-enabled high-speed photoacoustic endomicroscopy through a multimode fibre

    Zhao, T., Shi, M., Ourselin, S., Vercauteren, T. & Xia, W., 7 Mar 2022, SPIE Proceedings Volume 11960, Photons Plus Ultrasound: Imaging and Sensing 2022;. 6 p. 119600L

    Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

  39. Miniaturized transparent ultrasound sensor for photoacoustic endoscopy

    Zhao, T., Ourselin, S., Vercauteren, T. & Xia, W., 7 Mar 2022, Proceedings Volume 11960, Photons Plus Ultrasound: Imaging and Sensing 2022. SPIE, Vol. 11960. 5 p. 1196009

    Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

  40. Robotic Endoscope Control via Autonomous Instrument Tracking

    Garcia-Peraza-Herrera, L. C., Gruijthuijsen, C., Borghesan, G., Reynaerts, D., Deprest, J., Ourselin, S., Vercauteren, T. & Vander Poorten, E., 17 Feb 2022, (Accepted/In press) In: Frontiers in Robotics and AI. 39 p.

    Research output: Contribution to journalArticlepeer-review

  41. Fetoscopic insufflation of heated-humidified carbon dioxide during simulated spina bifida repair is safe under controlled anesthesia in the fetal lamb

    Joyeux, L., Basurto, D., Bleeser, T., Van der Veeken, L., Vergote, S., Kunpalin, Y., Trigo, L., Corno, E., De Bie, F. R., De Coppi, P., Ourselin, S., Van Calenbergh, F., Hooper, S. B., Rex, S. & Deprest, J., Feb 2022, In: Prenatal Diagnosis. 42, 2, p. 180-191 12 p.

    Research output: Contribution to journalArticlepeer-review

  42. Intraoperative overlay of optic radiation tractography during anteromesial temporal resection: a prospective validation study

    Vakharia, V. N., Vos, S. B., Winston, G. P., Gutman, M. J., Wykes, V., McEvoy, A. W., Miserocchi, A., Sparks, R., Ourselin, S. & Duncan, J. S., Feb 2022, In: Journal of Neurosurgery. 136, 2, p. 543-552 10 p.

    Research output: Contribution to journalArticlepeer-review

  43. OxVent: design and evaluation of a rapidly-manufactured Covid-19 ventilator

    Beale, R., Beddoe Rosendo, J., Bergeles, C., Beverly, A., Camporota, L., Castrejon-Pita, A. A., Crockett, D. C., Cronin, J., Denison, T., East, S., Edwardes, C., Farmery, A., Fele, F., Fisk, JA., Fuenteslopez, C. V., Garstka, M., Goulart, P., Heaysman, C., Hussain, A., Jha, P., & 16 othersKempf, I., Kumar, A. S., Moslein, A., Orr, A. CJ., Ourselin, S., Salisbury, D., Seneci, C., Staruch, R., Steel, H., Thompson, M., Tran, M., Vitiello, V., Perez Xochicale, M. A., Zhou, F., Formenti, F. & Kirk, T., 21 Jan 2022, (Accepted/In press) In: EBioMedicine.

    Research output: Contribution to journalArticlepeer-review

  44. Deep learning to automate the labelling of head MRI datasets for computer vision applications

    Wood, D. A., Kafiabadi, S., Al Busaidi, A., Guilhem, E. L., Lynch, J., Townend, M. K., Montvila, A., Kiik, M., Siddiqui, J., Gadapa, N., Benger, M. D., Mazumder, A., Barker, G., Ourselin, S., Cole, J. H. & Booth, T., Jan 2022, In: European Radiology. 32, 1, p. 725-736 12 p.

    Research output: Contribution to journalArticlepeer-review

  45. Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study

    Antonelli, M., Penfold, R. S., Merino, J., Sudre, C. H., Molteni, E., Berry, S., Canas, L. S., Graham, M. S., Klaser, K., Modat, M., Murray, B., Kerfoot, E., Chen, L., Deng, J., Österdahl, M. F., Cheetham, N. J., Drew, D. A., Nguyen, L. H., Pujol, J. C., Hu, C., & 10 othersSelvachandran, S., Polidori, L., May, A., Wolf, J., Chan, A. T., Hammers, A., Duncan, E. L., Spector, T. D., Ourselin, S. & Steves, C. J., Jan 2022, In: The Lancet infectious diseases. 22, 1, p. 43-55 13 p.

    Research output: Contribution to journalArticlepeer-review

  46. Automated Koos classification of Vestibular Schwannoma

    Kujawa, A., Dorent, R., Connor, S., Oviedova, A., Okasha, M., Grishchuk, D., Ourselin, S., Paddick, I., Kitchen, N., Vercauteren, T. & Shapey, J., 2022, In: Frontiers in Radiology.

    Research output: Contribution to journalArticlepeer-review

  47. CARRNN: A Continuous Autoregressive Recurrent Neural Network for Deep Representation Learning From Sporadic Temporal Data

    Ghazi, M. M., Sorensen, L., Ourselin, S. & Nielsen, M., 2022, (Accepted/In press) In: IEEE Transactions on Neural Networks and Learning Systems. p. 1-11 11 p.

    Research output: Contribution to journalArticlepeer-review

Previous 1 2 3 4 5 6 7 8 ...13 Next

Export:RIS BibTex Word PDF - will at most contain 500 items

Refine results Clear filters

Language

Language

Publication year

Publication year

Meeting and poster abstracts

Meeting and poster abstracts

Authors

Open Access Status

Open Access Status

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454