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Research Outputs

  1. 2020
  2. Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

    Giblin, L., McCarthy, F. P., Gill, C., Seed, P. T., Bramham, K., Brockbank, A., Chappell, L. C. & Shennan, A. H., Jul 2020, In : Pregnancy Hypertension. 21, p. 35-37 3 p.

    Research output: Contribution to journalArticle

  3. Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake

    Mompeo, O., Spector, T. D., Matey Hernandez, M., Le Roy, C., Istas, G., Le Sayec, M., Mangino, M., Jennings, A., Rodriguez-Mateos, A., Valdes, A. M. & Menni, C., 23 Jun 2020, In : Nutrients. 12, 6

    Research output: Contribution to journalArticle

  4. Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

    Bramham, K., Villa, P. M., Joslin, J. R., Laivuori, H., Hämäläinen, E., Kajantie, E., Räikkönen, K., Pesonen, A., Seed, P., Dalton, R. N., Turner, C., Wong, M., Von Dadelszen, P., Roberts, J. M., Poston, L. & Chappell, L. C., 1 Jun 2020, In : HYPERTENSION IN PREGNANCY. p. 1-10 10 p.

    Research output: Contribution to journalArticle

  5. Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

    Genome Aggregation Database Production Team & Genome Aggregation Database Consortium, 27 May 2020, In : Nature Communications. 11, 1, 2539.

    Research output: Contribution to journalArticle

  6. Real-time tracking of self-reported symptoms to predict potential COVID-19

    Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., Ganesh, S., Varsavsky, T., Cardoso, M. J., El-Sayed Moustafa, J. S., Visconti, A., Hysi, P., Bowyer, R. C. E., Mangino, M., Falchi, M., Wolf, J., Ourselin, S., Chan, A. T., Steves, C. J. & Spector, T. D., 11 May 2020, In : Nature Medicine.

    Research output: Contribution to journalArticle

  7. Rapid implementation of mobile technology for real-time epidemiology of COVID-19

    COPE Consortium, Drew, D. A., Nguyen, L. H., Steves, C. J., Menni, C., Freydin, M., Varsavsky, T., Sudre, C. H., Cardoso, M. J., Ourselin, S., Wolf, J., Spector, T. D. & Chan, A. T., 5 May 2020, In : Science.

    Research output: Contribution to journalArticle

  8. Pulmonary complications for women with sickle cell disease in pregnancy: systematic review and meta-analysis

    Inparaj, S., Buckingham, M., Oakley, L., Seed, P. T., Lucas, S. & Oteng-Ntim, E., 28 Apr 2020, In : Thorax.

    Research output: Contribution to journalArticle

  9. Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): study protocol for a randomised controlled feasibility trial

    Oakley, L. L., Awogbade, M., Brien, S., Briley, A., Chorozoglou, M., Drasar, E., Johns, J., Rhodes, E., Robinson, V., Seed, P., Sharif, J., Singh, C., Telfer, P., Thompson, H., Watt-Coote, I., Howard, J. & Oteng-Ntim, E., 20 Apr 2020, In : Trials. 21, 1, p. 347

    Research output: Contribution to journalArticle

  10. Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels

    Nag, A., Kurushima, Y., Bowyer, R. C. E., Wells, P. M., Weiss, S., Pietzner, M., Kocher, T., Raffler, J., Völker, U., Mangino, M., Spector, T. D., Milburn, M. V., Kastenmüller, G., Mohney, R. P., Suhre, K., Menni, C. & Steves, C. J., 27 Mar 2020, In : Human Molecular Genetics. 29, 5, p. 864-875 12 p., ddz308.

    Research output: Contribution to journalArticle

  11. Differences between race and sex in measures of hip morphology: a population-based comparative study

    Edwards, K., Leyland, K. M., Sanchez-Santos, M. T., Arden, C. P., Spector, T. D., Nelson, A. E., Jordan, J. M., Nevitt, M., Hunter, D. J. & Arden, N. K., 1 Feb 2020, In : Osteoarthritis and Cartilage. 28, 2, p. 189-200 12 p.

    Research output: Contribution to journalArticle

  12. Placental growth factor testing in suspected pre-eclampsia - Authors' reply

    Duhig, K., Myers, J., Seed, P. T., Shennan, A. H. & Chappell, L. C., 1 Feb 2020, In : Lancet. 395, 10221, p. 336-337 2 p.

    Research output: Contribution to journalLetter

  13. The incidence and characteristics of accelerated knee osteoarthritis among women: The Chingford cohort

    Driban, J. B., Bannuru, R. R., Eaton, C. B., Spector, T. D., Hart, D. J., McAlindon, T. E., Lu, B., Lo, G. H. & Arden, N. K., 31 Jan 2020, In : BMC MUSCULOSKELETAL DISORDERS. 21, 1, 60.

    Research output: Contribution to journalArticle

  14. An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

    Shomorony, I., Cirulli, E. T., Huang, L., Napier, L. A., Heister, R. R., Hicks, M., Cohen, I. V., Yu, H. C., Swisher, C. L., Schenker-Ahmed, N. M., Li, W., Nelson, K. E., Brar, P., Kahn, A. M., Spector, T. D., Caskey, C. T., Venter, J. C., Karow, D. S., Kirkness, E. F. & Shah, N., 10 Jan 2020, In : Genome medicine. 12, 1, 1 p., 7.

    Research output: Contribution to journalArticle

  15. Predicting Incident Radiographic Knee Osteoarthritis in Middle-Aged Women Within Four Years: The Importance of Knee-Level Prognostic Factors

    Garriga, C., Sánchez-Santos, M. T., Judge, A., Hart, D., Spector, T., Cooper, C. & Arden, N. K., 1 Jan 2020, In : Arthritis Care and Research. 72, 1, p. 88-97 10 p.

    Research output: Contribution to journalArticle

  16. Red Wine Consumption Associated With Increased Gut Microbiota α-Diversity in 3 Independent Cohorts

    Le Roy, C. I., Wells, P. M., Si, J., Raes, J., Bell, J. T. & Spector, T. D., Jan 2020, In : Gastroenterology. 158, 1, p. 270-272.e2

    Research output: Contribution to journalArticle

  17. 2019
  18. HLA Alleles Associated With Risk of Ankylosing Spondylitis and Rheumatoid Arthritis Influence the Gut Microbiome

    Asquith, M., Sternes, P. R., Costello, M. E., Karstens, L., Diamond, S., Martin, T. M., Li, Z., Marshall, M. S., Spector, T. D., le Cao, K. A., Rosenbaum, J. T. & Brown, M. A., 12 Dec 2019, In : Arthritis and Rheumatology. 71, 10, p. 1642-1650 9 p.

    Research output: Contribution to journalArticle

  19. Lifestyle information and commercial weight management groups to support maternal postnatal weight management and positive lifestyle behaviour: the SWAN feasibility randomised controlled trial

    Bick, D., Taylor, C., Bhavnani, V., Healey, A., Seed, P., Roberts, S., Zasada, M., Avery, A., Craig, V., Khazaezadah, N., McMullen, S., O'Connor, S., Oki, B., Oteng Ntim, E., Poston, L. & Ussher, M., 5 Dec 2019, In : BJOG. 27 p.

    Research output: Contribution to journalArticle

  20. A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

    Deelen, J., Kettunen, J., Fischer, K., van der Spek, A., Trompet, S., Kastenmüller, G., Boyd, A., Zierer, J., van den Akker, E. B., Ala-Korpela, M., Amin, N., Demirkan, A., Ghanbari, M., van Heemst, D., Ikram, M. A., van Klinken, J. B., Mooijaart, S. P., Peters, A., Salomaa, V., Sattar, N. & 15 others, Spector, T. D., Tiemeier, H., Verhoeven, A., Waldenberger, M., Würtz, P., Davey Smith, G., Metspalu, A., Perola, M., Menni, C., Geleijnse, J. M., Drenos, F., Beekman, M., Jukema, J. W., van Duijn, C. M. & Slagboom, P. E., 1 Dec 2019, In : Nature Communications. 10, 1, 3346.

    Research output: Contribution to journalArticle

  21. An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

    Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P. C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S. J. & 37 others, Bressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M. F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., 1 Dec 2019, In : Nature Communications. 10, 1, 2581.

    Research output: Contribution to journalArticle

  22. Effect of diet on the gut microbiota: Rethinking intervention duration

    Leeming, E. R., Johnson, A. J., Spector, T. D. & Roy, C. I. L., 1 Dec 2019, In : Nutrients. 11, 12, 2862.

    Research output: Contribution to journalReview article

  23. Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

    Borges Manna, L., Ovadia, C., Lövgren-Sandblom, A., Chambers, J., Begum, S., Seed, P., Walker, I., Chappell, L. C., Marschall, H-U. & Williamson, C., 1 Dec 2019, In : BJOG. 126, 13, p. 1633-1640 8 p.

    Research output: Contribution to journalArticle

  24. Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

    van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A. & 19 others, Medland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Eline Slagboom, P., Spector, T. D., Boomsma, D. I., van Duijn, C. M. & Gieger, C., 1 Dec 2019, In : Scientific Reports. 9, 1, 11623.

    Research output: Contribution to journalArticle

  25. Novel genetic loci affecting facial shape variation in humans

    International Visible Trait Genetics (VisiGen) Consortium, 26 Nov 2019, In : eLife. 8, e49898.

    Research output: Contribution to journalArticle

  26. Pregnancy-related Acute Kidney Injury in pre-eclampsia: risk factors and renal outcomes

    Conti-Ramsden, F. I., Nathan, H. L., De Greeff, A., Hall, D. R., Seed, P. T., Chappell, L. C., Shennan, A. H. & Bramham, K., Nov 2019, In : Hypertension. 74, 5, p. 1144–1151 8 p.

    Research output: Contribution to journalArticle

  27. Metabolomic profiling identifies novel associations with Electrolyte and Acid-Base Homeostatic patterns

    Menni, C., McCallum, L., Pietzner, M., Zierer, J. B., Aman, A., Suhre, K., Mohney, R., Mangino, M., Friedrich, N., Spector, T. D. & Padmanabhan, S., 21 Oct 2019, In : Scientific Reports. 9, 1, 8 p., 15088.

    Research output: Contribution to journalArticle

  28. Interplay between the human gut microbiome and host metabolism

    Visconti, A., Le Roy, C. I., Rosa, F., Martin, T. C., Mohney, R. P., Weizhong, L., de Rinaldis, E., Bell, J. T., Venter, J. C., Nelson, K. E., Spector, T. D. & Falchi, M., 3 Oct 2019, In : Nature Communications. 10, 1, 1 p., 4505.

    Research output: Contribution to journalArticle

  29. Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

    on behalf of SCOPE consortium, 1 Oct 2019, In : Pediatric Obesity. 14, 10, 12 p., e12537.

    Research output: Contribution to journalArticle

  30. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

    Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A. R., Pazoki, R., Suzuki, H., Koskeridis, F., Yiorkas, A. M., Karaman, I., Elliott, J., Luo, Q., Aeschbacher, S., Bartz, T. M., Baumeister, S. E., Braund, P. S., Brown, M. R., Brody, J. A., Clarke, T. K. & 78 others, Dimou, N., Faul, J. D., Homuth, G., Jackson, A. U., Kentistou, K. A., Joshi, P. K., Lemaitre, R. N., Lind, P. A., Lyytikäinen, L. P., Mangino, M., Milaneschi, Y., Nelson, C. P., Nolte, I. M., Perälä, M. M., Polasek, O., Porteous, D., Ratliff, S. M., Smith, J. A., Stančáková, A., Teumer, A., Tuominen, S., Thériault, S., Vangipurapu, J., Whitfield, J. B., Wood, A., Yao, J., Yu, B., Zhao, W., Arking, D. E., Auvinen, J., Liu, C., Männikkö, M., Risch, L., Rotter, J. I., Snieder, H., Veijola, J., Blakemore, A. I., Boehnke, M., Campbell, H., Conen, D., Eriksson, J. G., Grabe, H. J., Guo, X., van der Harst, P., Hartman, C. A., Hayward, C., Heath, A. C., Jarvelin, M. R., Kähönen, M., Kardia, S. L. R., Kühne, M., Kuusisto, J., Laakso, M., Lahti, J., Lehtimäki, T., McIntosh, A. M., Mohlke, K. L., Morrison, A. C., Martin, N. G., Oldehinkel, A. J., Penninx, B. W. J. H., Psaty, B. M., Raitakari, O. T., Rudan, I., Samani, N. J., Scott, L. J., Spector, T. D., Verweij, N., Weir, D. R., Wilson, J. F., Levy, D., Tzoulaki, I., Bell, J. D., Matthews, P. M., Rothenfluh, A., Desrivières, S., Schumann, G. & Elliott, P., 1 Sep 2019, In : Nature Human Behaviour. 3, 9, p. 950-961 12 p.

    Research output: Contribution to journalArticle

  31. Body site-specific genetic effects influence naevus count distribution in women

    Visconti, A., Ribero, S., Sanna, M., Spector, T. D., Bataille, V. & Falchi, M., 12 Aug 2019, In : Pigment cell & melanoma research.

    Research output: Contribution to journalArticle

  32. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

    Spracklen, C. N., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R. S., Kutalik, Z., Preuss, M. H., Lu, Y., Wittemans, L. B. L., Adair, L. S., Allison, M., Amin, N., Auer, P. L., Bartz, T. M., Blüher, M., Boehnke, M., Borja, J. B., Bork-Jensen, J., Broer, L., Chasman, D. I. & 84 others, Chen, Y. D. I., Chirstofidou, P., Demirkan, A., van Duijn, C. M., Feitosa, M. F., Garcia, M. E., Graff, M., Grallert, H., Grarup, N., Guo, X., Haesser, J., Hansen, T., Harris, T. B., Highland, H. M., Hong, J., Ikram, M. A., Ingelsson, E., Jackson, R., Jousilahti, P., Kähönen, M., Kizer, J. R., Kovacs, P., Kriebel, J., Laakso, M., Lange, L. A., Lehtimäki, T., Li, J., Li-Gao, R., Lind, L., Luan, J., Lyytikäinen, L. P., MacGregor, S., Mackey, D. A., Mahajan, A., Mangino, M., Männistö, S., McCarthy, M. I., McKnight, B., Medina-Gomez, C., Meigs, J. B., Molnos, S., Mook-Kanamori, D., Morris, A. P., de Mutsert, R., Nalls, M. A., Nedeljkovic, I., North, K. E., Pennell, C. E., Pradhan, A. D., Province, M. A., Raitakari, O. T., Raulerson, C. K., Reiner, A. P., Ridker, P. M., Ripatti, S., Roberston, N., Rotter, J. I., Salomaa, V., Sandoval-Zárate, A. A., Sitlani, C. M., Spector, T. D., Strauch, K., Stumvoll, M., Taylor, K. D., Thuesen, B., Tönjes, A., Uitterlinden, A. G., Venturini, C., Walker, M., Wang, C. A., Wang, S., Wareham, N. J., Willems, S. M., Willems van Dijk, K., Wilson, J. G., Wu, Y., Yao, J., Young, K. L., Langenberg, C., Frayling, T. M., Kilpeläinen, T. O., Lindgren, C. M., Loos, R. J. F. & Mohlke, K. L., 3 Jul 2019, In : American Journal of Human Genetics. 105, 1, p. 15-28 14 p.

    Research output: Contribution to journalArticle

  33. Genome-Wide Association Studies Identify Multiple Genetic Loci Influencing Eyebrow Color Variation in Europeans

    International Visible Trait Genetics Consortium, 1 Jul 2019, In : Journal of Investigative Dermatology. 139, 7, p. 1601-1605 5 p.

    Research output: Contribution to journalArticle

  34. Quantifying adherence to antihypertensive medication for chronic hypertension during pregnancy

    Webster, L. M., Reed, K., Myers, J. E., Burns, A., Gupta, P., Patel, P., Wiesender, C., Seed, P. T., Nelson-Piercy, C. & Chappell, L. C., 1 Jul 2019, In : Pregnancy Hypertension. 17, p. 12-14 3 p.

    Research output: Contribution to journalArticle

  35. Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

    Suhre, K., Trbojević-Akmačić, I., Ugrina, I., Mook-Kanamori, D. O., Spector, T., Graumann, J., Lauc, G. & Falchi, M., 26 Jun 2019, In : Metabolites. 9, 7, 122.

    Research output: Contribution to journalArticle

  36. Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

    Noordam, R., Young, W. J., Salman, R., Kanters, J. K., van den Berg, M. E., van Heemst, D., Lin, H. J., Barreto, S. M., Biggs, M. L., Biino, G., Catamo, E., Concas, M. P., Ding, J., Evans, D. S., Foco, L., Grarup, N., Lyytikäinen, L. P., Mangino, M., Mei, H., van der Most, P. J. & 83 others, Müller-Nurasyid, M., Nelson, C. P., Qian, Y., Repetto, L., Said, M. A., Shah, N., Schramm, K., Vidigal, P. G., Weiss, S., Yao, J., Zilhao, N. R., Brody, J. A., Braund, P. S., Brumat, M., Campana, E., Christofidou, P., Caulfield, M. J., De Grandi, A., Dominiczak, A. F., Doney, A. S. F., Eiriksdottir, G., Ellervik, C., Giatti, L., Gögele, M., Graff, C., Guo, X., van der Harst, P., Joshi, P. K., Kähönen, M., Kestenbaum, B., Lima-Costa, M. F., Linneberg, A., Maan, A. C., Meitinger, T., Padmanabhan, S., Pattaro, C., Peters, A., Petersmann, A., Sever, P., Sinner, M. F., Shen, X., Stanton, A., Strauch, K., Soliman, E. Z., Tarasov, K. V., Taylor, K. D., Thio, C. H. L., Uitterlinden, A. G., Vaccargiu, S., Waldenberger, M., Robino, A., Correa, A., Cucca, F., Cummings, S. R., Dörr, M., Girotto, G., Gudnason, V., Hansen, T., Heckbert, S. R., Juhl, C. R., Kääb, S., Lehtimäki, T., Liu, Y., Lotufo, P. A., Palmer, C. N. A., Pirastu, M., Pramstaller, P. P., Ribeiro, A. L. P., Rotter, J. I., Samani, N. J., Snieder, H., Spector, T. D., Stricker, B. H., Verweij, N., Wilson, J. F., Wilson, J. G., Jukema, J. W., Tinker, A., Newton-Cheh, C. H., Sotoodehnia, N., Mook-Kanamori, D. O., Munroe, P. B. & Warren, H. R., 25 Jun 2019, In : Journal of the American College of Cardiology. 73, 24, p. 3118-3131 14 p.

    Research output: Contribution to journalArticle

  37. The impacted foetal head at caesarean section: incidence and techniques used in a single UK institution

    Rice, A., Tydeman, G., Briley, A. & Seed, P. T., 19 Jun 2019, In : Journal of Obstetrics and Gynaecology. 39, 7, p. 948-951 4 p.

    Research output: Contribution to journalArticle

  38. Defining the genetic control of human blood plasma N-glycome using genome-wide association study

    Sharapov, S. Z., Tsepilov, Y. A., Klaric, L., Mangino, M., Thareja, G., Shadrina, A. S., Simurina, M., Dagostino, C., Dmitrieva, J., Vilaj, M., Vuckovic, F., Pavic, T., Stambuk, J., Trbojevic-Akmacic, I., Kristic, J., Simunovic, J., Momcilovic, A., Campbell, H., Doherty, M., Dunlop, M. G. & 11 others, Farrington, S. M., Pucic-Bakovic, M., Gieger, C., Allegri, M., Louis, E., Georges, M., Suhre, K., Spector, T., Williams, F. M. K., Lauc, G. & Aulchenko, Y. S., 15 Jun 2019, In : Human Molecular Genetics. 28, 12, p. 2062-2077 16 p.

    Research output: Contribution to journalArticle

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