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  1. 2020
  2. An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

    Roubroeks, J. A. Y., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., Hannon, E. J., Kłoszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Wahlund, L. O., Aarsland, D., Proitsi, P., Hodges, A., Lovestone, S., Newhouse, S. J., Dobson, R. J. B., Mill, J. & 2 others, van den Hove, D. L. A. & Lunnon, K., Nov 2020, In : Neurobiology of Aging. 95, p. 26-45 20 p.

    Research output: Contribution to journalArticle

  3. The effect of smoking on COVID-19 severity: a systematic review and meta-analysis

    Reddy, R. K., Charles, W. N., Sklavounos, A., Dutt, A., Seed, P. T. & Khajuria, A., 4 Aug 2020, In : Journal of Medical Virology.

    Research output: Contribution to journalArticle

  4. Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals

    Colicino, E., Marioni, R., Ward-Caviness, C., Gondalia, R., Guan, W., Chen, B., Tsai, P. C., Huan, T., Xu, G., Golareh, A., Schwartz, J., Vokonas, P., Just, A., Starr, J. M., McRae, A. F., Wray, N. R., Visscher, P. M., Bressler, J., Zhang, W., Tanaka, T. & 29 others, Moore, A. Z., Pilling, L. C., Zhang, G., Stewart, J. D., Li, Y., Hou, L., Castillo-Fernandez, J., Spector, T., Kiel, D. P., Murabito, J. M., Liu, C., Mendelson, M., Assimes, T., Absher, D., Tsaho, P. S., Lu, A. T., Ferrucci, L., Wilson, R., Waldenberger, M., Prokisch, H., Bandinelli, S., Bell, J. T., Levy, D., Deary, I. J., Horvath, S., Pankow, J., Peters, A., Whitsel, E. A. & Baccarelli, A., 31 Jul 2020, In : Aging. 12, 14, p. 14092-14124 33 p.

    Research output: Contribution to journalArticle

  5. Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

    Giblin, L., McCarthy, F. P., Gill, C., Seed, P. T., Bramham, K., Brockbank, A., Chappell, L. C. & Shennan, A. H., Jul 2020, In : Pregnancy Hypertension. 21, p. 35-37 3 p.

    Research output: Contribution to journalArticle

  6. The UK pregnancies better eating and activity trial (UPBEAT); pregnancy outcomes and health behaviours by obesity class

    Peacock, L., Seed, P. T., Dalrymple, K. V., White, S. L., Poston, L. & Flynn, A. C., Jul 2020, In : International Journal of Environmental Research and Public Health. 17, 13, p. 1-17 17 p., 4712.

    Research output: Contribution to journalArticle

  7. Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake

    Mompeo, O., Spector, T. D., Matey Hernandez, M., Le Roy, C., Istas, G., Le Sayec, M., Mangino, M., Jennings, A., Rodriguez-Mateos, A., Valdes, A. M. & Menni, C., 23 Jun 2020, In : Nutrients. 12, 6

    Research output: Contribution to journalArticle

  8. Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

    Bramham, K., Villa, P. M., Joslin, J. R., Laivuori, H., Hämäläinen, E., Kajantie, E., Räikkönen, K., Pesonen, A., Seed, P., Dalton, R. N., Turner, C., Wong, M., Von Dadelszen, P., Roberts, J. M., Poston, L. & Chappell, L. C., 1 Jun 2020, In : HYPERTENSION IN PREGNANCY. p. 1-10 10 p.

    Research output: Contribution to journalArticle

  9. Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

    Genome Aggregation Database Production Team & Genome Aggregation Database Consortium, 27 May 2020, In : Nature Communications. 11, 1, 2539.

    Research output: Contribution to journalArticle

  10. Real-time tracking of self-reported symptoms to predict potential COVID-19

    Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., Ganesh, S., Varsavsky, T., Cardoso, M. J., El-Sayed Moustafa, J. S., Visconti, A., Hysi, P., Bowyer, R. C. E., Mangino, M., Falchi, M., Wolf, J., Ourselin, S., Chan, A. T., Steves, C. J. & Spector, T. D., 11 May 2020, In : Nature Medicine.

    Research output: Contribution to journalArticle

  11. Rapid implementation of mobile technology for real-time epidemiology of COVID-19

    COPE Consortium, Drew, D. A., Nguyen, L. H., Steves, C. J., Menni, C., Freydin, M., Varsavsky, T., Sudre, C. H., Cardoso, M. J., Ourselin, S., Wolf, J., Spector, T. D. & Chan, A. T., 5 May 2020, In : Science.

    Research output: Contribution to journalArticle

  12. Pulmonary complications for women with sickle cell disease in pregnancy: systematic review and meta-analysis

    Inparaj, S., Buckingham, M., Oakley, L., Seed, P. T., Lucas, S. & Oteng-Ntim, E., 28 Apr 2020, In : Thorax.

    Research output: Contribution to journalArticle

  13. Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): study protocol for a randomised controlled feasibility trial

    Oakley, L. L., Awogbade, M., Brien, S., Briley, A., Chorozoglou, M., Drasar, E., Johns, J., Rhodes, E., Robinson, V., Seed, P., Sharif, J., Singh, C., Telfer, P., Thompson, H., Watt-Coote, I., Howard, J. & Oteng-Ntim, E., 20 Apr 2020, In : Trials. 21, 1, p. 347

    Research output: Contribution to journalArticle

  14. Dysregulated Fc gamma receptor–mediated phagocytosis pathway in Alzheimer's disease: network-based gene expression analysis

    AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative, Apr 2020, In : Neurobiology of Aging. 88, p. 24-32 9 p.

    Research output: Contribution to journalArticle

  15. Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels

    Nag, A., Kurushima, Y., Bowyer, R. C. E., Wells, P. M., Weiss, S., Pietzner, M., Kocher, T., Raffler, J., Völker, U., Mangino, M., Spector, T. D., Milburn, M. V., Kastenmüller, G., Mohney, R. P., Suhre, K., Menni, C. & Steves, C. J., 27 Mar 2020, In : Human Molecular Genetics. 29, 5, p. 864-875 12 p., ddz308.

    Research output: Contribution to journalArticle

  16. Differences between race and sex in measures of hip morphology: a population-based comparative study

    Edwards, K., Leyland, K. M., Sanchez-Santos, M. T., Arden, C. P., Spector, T. D., Nelson, A. E., Jordan, J. M., Nevitt, M., Hunter, D. J. & Arden, N. K., 1 Feb 2020, In : Osteoarthritis and Cartilage. 28, 2, p. 189-200 12 p.

    Research output: Contribution to journalArticle

  17. Placental growth factor testing in suspected pre-eclampsia - Authors' reply

    Duhig, K., Myers, J., Seed, P. T., Shennan, A. H. & Chappell, L. C., 1 Feb 2020, In : Lancet. 395, 10221, p. 336-337 2 p.

    Research output: Contribution to journalLetter

  18. The incidence and characteristics of accelerated knee osteoarthritis among women: The Chingford cohort

    Driban, J. B., Bannuru, R. R., Eaton, C. B., Spector, T. D., Hart, D. J., McAlindon, T. E., Lu, B., Lo, G. H. & Arden, N. K., 31 Jan 2020, In : BMC MUSCULOSKELETAL DISORDERS. 21, 1, 60.

    Research output: Contribution to journalArticle

  19. An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

    Shomorony, I., Cirulli, E. T., Huang, L., Napier, L. A., Heister, R. R., Hicks, M., Cohen, I. V., Yu, H. C., Swisher, C. L., Schenker-Ahmed, N. M., Li, W., Nelson, K. E., Brar, P., Kahn, A. M., Spector, T. D., Caskey, C. T., Venter, J. C., Karow, D. S., Kirkness, E. F. & Shah, N., 10 Jan 2020, In : Genome medicine. 12, 1, 1 p., 7.

    Research output: Contribution to journalArticle

  20. Predicting Incident Radiographic Knee Osteoarthritis in Middle-Aged Women Within Four Years: The Importance of Knee-Level Prognostic Factors

    Garriga, C., Sánchez-Santos, M. T., Judge, A., Hart, D., Spector, T., Cooper, C. & Arden, N. K., 1 Jan 2020, In : Arthritis Care and Research. 72, 1, p. 88-97 10 p.

    Research output: Contribution to journalArticle

  21. Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort

    Westwood, S., Baird, A. L., Anand, S. N., Nevado-Holgado, A. J., Kormilitzin, A., Shi, L., Hye, A., Ashton, N. J., Morgan, A. R., Bos, I., Vos, S. J. B., Baker, S., Buckley, N. J., Ten Kate, M., Scheltens, P., Teunissen, C. E., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S. & 30 others, De Roeck, E. E., Sleegers, K., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lléo, A., Sala, I., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Morgan, B. P., Streffer, J., Visser, P. J. & Lovestone, S., 1 Jan 2020, In : Journal of Alzheimer's Disease. 74, 1, p. 213-225 13 p.

    Research output: Contribution to journalArticle

  22. Red Wine Consumption Associated With Increased Gut Microbiota α-Diversity in 3 Independent Cohorts

    Le Roy, C. I., Wells, P. M., Si, J., Raes, J., Bell, J. T. & Spector, T. D., Jan 2020, In : Gastroenterology. 158, 1, p. 270-272.e2

    Research output: Contribution to journalArticle

  23. Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: A multi-national multi-database case-control study

    Newby, D., Prieto-Alhambra, D., Duarte-Salles, T., Ansell, D., Pedersen, L., Van Der Lei, J., Mosseveld, M., Rijnbeek, P., James, G., Alexander, M., Egger, P., Podhorna, J., Stewart, R., Perera, G., Avillach, P., Grosdidier, S., Lovestone, S. & Nevado-Holgado, A. J., 2020, In : Alzheimer's Research and Therapy. 12, 1, 38.

    Research output: Contribution to journalArticle

  24. 2019
  25. HLA Alleles Associated With Risk of Ankylosing Spondylitis and Rheumatoid Arthritis Influence the Gut Microbiome

    Asquith, M., Sternes, P. R., Costello, M. E., Karstens, L., Diamond, S., Martin, T. M., Li, Z., Marshall, M. S., Spector, T. D., le Cao, K. A., Rosenbaum, J. T. & Brown, M. A., 12 Dec 2019, In : Arthritis and Rheumatology. 71, 10, p. 1642-1650 9 p.

    Research output: Contribution to journalArticle

  26. Lifestyle information and commercial weight management groups to support maternal postnatal weight management and positive lifestyle behaviour: the SWAN feasibility randomised controlled trial

    Bick, D., Taylor, C., Bhavnani, V., Healey, A., Seed, P., Roberts, S., Zasada, M., Avery, A., Craig, V., Khazaezadah, N., McMullen, S., O'Connor, S., Oki, B., Oteng Ntim, E., Poston, L. & Ussher, M., 5 Dec 2019, In : BJOG. 27 p.

    Research output: Contribution to journalArticle

  27. A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

    Deelen, J., Kettunen, J., Fischer, K., van der Spek, A., Trompet, S., Kastenmüller, G., Boyd, A., Zierer, J., van den Akker, E. B., Ala-Korpela, M., Amin, N., Demirkan, A., Ghanbari, M., van Heemst, D., Ikram, M. A., van Klinken, J. B., Mooijaart, S. P., Peters, A., Salomaa, V., Sattar, N. & 15 others, Spector, T. D., Tiemeier, H., Verhoeven, A., Waldenberger, M., Würtz, P., Davey Smith, G., Metspalu, A., Perola, M., Menni, C., Geleijnse, J. M., Drenos, F., Beekman, M., Jukema, J. W., van Duijn, C. M. & Slagboom, P. E., 1 Dec 2019, In : Nature Communications. 10, 1, 3346.

    Research output: Contribution to journalArticle

  28. An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

    Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P. C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S. J. & 37 others, Bressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M. F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., 1 Dec 2019, In : Nature Communications. 10, 1, 2581.

    Research output: Contribution to journalArticle

  29. Effect of diet on the gut microbiota: Rethinking intervention duration

    Leeming, E. R., Johnson, A. J., Spector, T. D. & Roy, C. I. L., 1 Dec 2019, In : Nutrients. 11, 12, 2862.

    Research output: Contribution to journalReview article

  30. Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

    Borges Manna, L., Ovadia, C., Lövgren-Sandblom, A., Chambers, J., Begum, S., Seed, P., Walker, I., Chappell, L. C., Marschall, H-U. & Williamson, C., 1 Dec 2019, In : BJOG. 126, 13, p. 1633-1640 8 p.

    Research output: Contribution to journalArticle

  31. Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

    van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A. & 19 others, Medland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Eline Slagboom, P., Spector, T. D., Boomsma, D. I., van Duijn, C. M. & Gieger, C., 1 Dec 2019, In : Scientific Reports. 9, 1, 11623.

    Research output: Contribution to journalArticle

  32. Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer's Disease

    for the AddNeuroMed consortium, 1 Dec 2019, In : Scientific Reports. 9, 1, 3147.

    Research output: Contribution to journalArticle

  33. Novel genetic loci affecting facial shape variation in humans

    International Visible Trait Genetics (VisiGen) Consortium, 26 Nov 2019, In : eLife. 8, e49898.

    Research output: Contribution to journalArticle

  34. Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

    Alzheimer's Disease Neuroimaging Initiative, 1 Nov 2019, In : The Lancet Neurology. 18, 11, p. 1034-1044 11 p.

    Research output: Contribution to journalArticle

  35. Pregnancy-related Acute Kidney Injury in pre-eclampsia: risk factors and renal outcomes

    Conti-Ramsden, F. I., Nathan, H. L., De Greeff, A., Hall, D. R., Seed, P. T., Chappell, L. C., Shennan, A. H. & Bramham, K., Nov 2019, In : Hypertension. 74, 5, p. 1144–1151 8 p.

    Research output: Contribution to journalArticle

  36. Metabolomic profiling identifies novel associations with Electrolyte and Acid-Base Homeostatic patterns

    Menni, C., McCallum, L., Pietzner, M., Zierer, J. B., Aman, A., Suhre, K., Mohney, R., Mangino, M., Friedrich, N., Spector, T. D. & Padmanabhan, S., 21 Oct 2019, In : Scientific Reports. 9, 1, 8 p., 15088.

    Research output: Contribution to journalArticle

  37. Interplay between the human gut microbiome and host metabolism

    Visconti, A., Le Roy, C. I., Rosa, F., Martin, T. C., Mohney, R. P., Weizhong, L., de Rinaldis, E., Bell, J. T., Venter, J. C., Nelson, K. E., Spector, T. D. & Falchi, M., 3 Oct 2019, In : Nature Communications. 10, 1, 1 p., 4505.

    Research output: Contribution to journalArticle

  38. Common brain disorders are associated with heritable patterns of apparent aging of the brain

    Karolinska Schizophrenia Project (KaSP), 1 Oct 2019, In : Nature Neuroscience. 22, 10, p. 1617-1623 7 p.

    Research output: Contribution to journalArticle

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