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Research Outputs

  1. 2013
  2. The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder

    Smith, B. N., Newhouse, S., Shatunov, A., Vance, C., Topp, S., Johnson, L., Miller, J., Lee, Y., Troakes, C., Scott, K. M., Jones, A., Gray, I., Wright, J., Hortobágyi, T., Al-Sarraj, S., Rogelj, B., Powell, J., Lupton, M., Lovestone, S., Sapp, P. C. & 26 others, Weber, M., Nestor, P. J., Schelhaas, H. J., Asbroek, A. A. T., Silani, V., Gellera, C., Taroni, F., Ticozzi, N., Van den Berg, L., Veldink, J., Van Damme, P., Robberecht, W., Shaw, P. J., Kirby, J., Pall, H., Morrison, K. E., Morris, A., de Belleroche, J., Vianney de Jong, J. M. B., Baas, F., Andersen, P. M., Landers, J., Brown, R. H., Weale, M. E., Al-Chalabi, A. & Shaw, C. E., Jan 2013, In : European Journal of Human Genetics. 21, 1, p. 102-108 7 p., N/A.

    Research output: Contribution to journalArticle

  3. A Blood Gene Expression Marker of Early Alzheimer's Disease

    Lunnon, K., Sattlecker, M., Furney, S. J., Coppola, G., Simmons, A., Proitsi, P., Lupton, M. K., Lourdusamy, A., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Geschwind, D., Lovestone, S., Dobson, R., Hodges, A. & AddNeuroMed Consortium, 2013, In : JOURNAL OF ALZHEIMERS DISEASE. 33, 3, p. 737-753 17 p.

    Research output: Contribution to journalArticle

  4. Candidate Blood Proteome Markers of Alzheimer’s Disease Onset and Progression: A Systematic Review and Replication Study

    Kiddle, S., Sattlecker, M., Proitsi, P., Simmons, A., Westman, E., Bazenet, C., Nelson, S., Williams, S., Hodges, A., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Newhouse, S., Lovestone, S. & Dobson, R., 2013, In : JOURNAL OF ALZHEIMERS DISEASE. N/A, N/A, p. N/A N/A.

    Research output: Contribution to journalArticle

  5. Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease

    Velayudhan, L., Proitsi, P., Westman, E., Muehlboeck, J-S., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., Spenger, C., Hodges, A., Powell, J., Lovestone, S., Simmons, A. & AddNeuroMed Consortium, 2013, In : JOURNAL OF ALZHEIMERS DISEASE. 33, 3, p. 755-766 12 p.

    Research output: Contribution to journalArticle

  6. Trait, State, and Mechanism: Looking Back, Looking Forward, and Understanding Why

    Lovestone, S., 2013, In : JOURNAL OF ALZHEIMERS DISEASE. 33, s1, p. S23-S33 11 p., N/A.

    Research output: Contribution to journalLiterature review

  7. 2012
  8. Limited Relationship between Cervico-Vaginal Fluid Cytokine Profiles and Cervical Shortening in Women at High Risk of Spontaneous Preterm Birth

    Chandiramani, M., Seed, P. T., Orsi, N. M., Ekbote, U. V., Bennett, P. R., Shennan, A. H. & Tribe, R. M., 26 Dec 2012, In : PL o S One . 7, 12, p. N/A 11 p., e52412.

    Research output: Contribution to journalArticle

  9. Genome-wide association study of Alzheimer's disease with psychotic symptoms

    Hollingworth, P., Sweet, R., Sims, R., Harold, D., Russo, G., Abraham, R., Stretton, A., Jones, N., Gerrish, A., Chapman, J., Ivanov, D., Moskvina, V., Lovestone, S., Priotsi, P., Lupton, M., Brayne, C., Gill, M., Lawlor, B., Lynch, A., Craig, D. & 23 others, McGuinness, B., Johnston, J., Holmes, C., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Holmans, P., Jones, L., Devlin, B., Klei, L., Barmada, M. M., Demirci, F. Y., DeKosky, S. T., Lopez, O. L., Passmore, P., Owen, M. J., O'Donovan, M. C., Mayeux, R., Kamboh, M. I., Williams, J., GERAD Consortium & Natl Inst Aging Late-Onset Alzheim, Dec 2012, In : Molecular Psychiatry. 17, 12, p. 1316-1327 12 p., N/A.

    Research output: Contribution to journalArticle

  10. The development and validation of a tool to predict spontaneous preterm birth in high-risk women

    Foster, C., Smout, E., Abbott, D., Van der Westhuizen, M., Seed, P. & Shennan, A., Dec 2012, In : Australian and New Zealand Journal of Obstetrics and Gynaecology. 52, 6, p. 600-600 1 p.

    Research output: Contribution to journalMeeting abstract

  11. Wnt3a induces exosome secretion from primary cultured rat microglia

    Hooper, C., Sainz-Fuertes, R., Lynham, S., Hye, A., Killick, R., Warley, A., Bolondi, C., Pocock, J. & Lovestone, S., 23 Nov 2012, In : BMC NEUROSCIENCE. 13, 17 p., 144.

    Research output: Contribution to journalArticle

  12. Hunting for biomarkers: The complement system in Alzheimer's disease

    Hakobyan, S., Aiyaz, M., Stretton, A., Sattlecker, M., Dobson, R., Harris, C., Morgan, P. & Lovestone, S., Nov 2012, In : Immunobiology. 217, 11, p. 1175-1175 1 p., 131.

    Research output: Contribution to journalMeeting abstract

  13. Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

    Greco, I., Day, N., Riddoch-Contreras, J., Reed, J., Soininen, H., Kloszewska, I., Tsolaki, M., Vellas, B., Spenger, C., Mecocci, P., Wahlund, L-O., Simmons, A., Barnes, J. & Lovestone, S., 31 Oct 2012, In : Journal Of Translational Medicine. 10, 10 p., 217.

    Research output: Contribution to journalArticle

  14. Managing hypertension in general practice: a cross-sectional study of treatment and ethnicity

    Schofield, P., Baawuah, F., Seed, P. T. & Ashworth, M., Oct 2012, In : British Journal of General Practice. 62, 603, p. e703-e709 7 p., N/A.

    Research output: Contribution to journalArticle

  15. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

    Mangialasche, F., Xu, W., Kivipelto, M., Costanzi, E., Ercolani, S., Pigliautile, M., Cecchetti, R., Baglioni, M., Simmons, A., Soininen, H., Tsolaki, M., Kloszewska, I., Vellas, B., Lovestone, S., Mecocci, P. & AddNeuroMed Consortium, Oct 2012, In : Neurobiology of Aging. 33, 10, p. 2282-2290 9 p.

    Research output: Contribution to journalArticle

  16. Plasma based markers of [11C] PiB-PET brain amyloid burden

    Kiddle, S. J., Thambisetty, M., Simmons, A., Riddoch-Contreras, J., Hye, A., Westman, E., Pike, I., Ward, M., Johnston, C., Lupton, M. K., Lunnon, K., Soininen, H., Kloszewska, I., Tsolaki, M., Vellas, B., Mecocci, P., Lovestone, S., Newhouse, S. & Dobson, R., 24 Sep 2012, In : PL o S One . 7, 9, 10 p., e44260.

    Research output: Contribution to journalArticle

  17. Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis

    Liu, Y., Julkunen, V., Paajanen, T., Westman, E., Wahlund, L-O., Aitken, A., Sobow, T., Mecocci, P., Tsolaki, M., Vellas, B., Muehlboeck, S., Spenger, C., Lovestone, S., Simmons, A., Soininen, H. & AddNeuroMed Consortium, Sep 2012, In : Neuroradiology. 54, 9, p. 929-938 10 p.

    Research output: Contribution to journalArticle

  18. Identification of cis-regulatory variation influencing protein abundance levels in human plasma

    Lourdusamy, A., Newhouse, S., Lunnon, K., Proitsi, P., Powell, J., Hodges, A., Nelson, S. K., Stewart, A., Williams, S., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S., Dobson, R. & Consortium, A., 15 Aug 2012, In : Human Molecular Genetics. 21, 16, p. 3719-3726 8 p.

    Research output: Contribution to journalArticle

  19. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimers diseases

    Coppola, G., Chinnathambi, S., Lee, J. J., Dombroski, B. A., Baker, M. C., Soto-Ortolaza, A. I., Lee, S. E., Klein, E., Huang, A. Y., Sears, R., Lane, J. R., Karydas, A. M., Kenet, R. O., Biernat, J., Wang, L-S., Cotman, C. W., DeCarli, C. S., Levey, A. I., Ringman, J. M., Mendez, M. F. & 31 others, Chui, H. C., Le Ber, I., Brice, A., Lupton, M. K., Preza, E., Lovestone, S., Powell, J., Graff-Radford, N., Petersen, R. C., Boeve, B. F., Lippa, C. F., Bigio, E. H., Mackenzie, I., Finger, E., Kertesz, A., Caselli, R. J., Gearing, M., Juncos, J. L., Ghetti, B., Spina, S., Bordelon, Y. M., Tourtellotte, W. W., Frosch, M. P., Vonsattel, J. P. G., Zarow, C., Beach, T. G., Albin, R. L., Lieberman, A. P., Lee, V. M., Trojanowski, J. Q. & Alzheimer's Dis Genetics Consortiu, 1 Aug 2012, In : Human Molecular Genetics. 21, 15, p. 3500-3512 13 p., dds161.

    Research output: Contribution to journalArticle

  20. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation

    Proitsi, P., Lupton, M. K., Dudbridge, F., Tsolaki, M., Hamilton, G., Daniilidou, M., Pritchard, M., Lord, K., Martin, B. M., Craig, D., Todd, S., McGuinness, B., Hollingworth, P., Harold, D., Kloszewska, I., Soininen, H., Mecocci, P., Velas, B., Gill, M., Lawlor, B. & 6 others, Rubinsztein, D. C., Brayne, C., Passmore, P. A., Williams, J., Lovestone, S. & Powell, J. F., Aug 2012, In : Neurobiology of Aging. 33, 8, p. 1843.e9-1843.e17 9 p., 1843.

    Research output: Contribution to journalArticle

  21. Genetic variants influencing human aging from late-onset Alzheimertextquotesingles disease (LOAD) genome-wide association studies (GWAS)

    Shi, H., Belbin, O., Medway, C., Brown, K., Kalsheker, N., Carrasquillo, M., Proitsi, P., Powell, J., Lovestone, S., Goate, A., Younkin, S., Passmore, P. & Morgan, K., Aug 2012, In : Neurobiology of Aging. 33, 8, p. 1849.e5-1849.e18 14 p., 1849.

    Research output: Contribution to journalArticle

  22. Plasma biomarkers for Alzheimer's disease: much needed but tough to find

    Bazenet, C. & Lovestone, S., Aug 2012, In : Biomarkers in Medicine. 6, 4, p. 441-454 14 p.

    Research output: Contribution to journalLiterature review

  23. Ageing Increases Vulnerability to A beta 42 Toxicity in Drosophila

    Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S. & Partridge, L., 12 Jul 2012, In : PL o S One . 7, 7, p. - 11 p., e40569.

    Research output: Contribution to journalArticle

  24. Classification of Alzheimer's disease using multiplex plasma-based biomarkers

    Hye, A., Riddoch-Contreras, J., Baird, A., Ashton, N., Sattlecker, M., Dobson, R., Ward, M., Pike, I. & Lovestone, S., Jul 2012, In : Alzheimer's & Dementia. 8, 4, Supplement, p. P407-P407 1 p., P2-408.

    Research output: Contribution to journalMeeting abstract

  25. Genome-wide association analysis identifies common variants associated with measures of disease progression in patients with Alzheimer's disease

    Newhouse, S., Proitsi, P., Sattlecker, M., Lunnon, K., Ibrahim, Z., Johnston, C., Lourdusamy, A., Lupton, M., Powell, J., Khondoker, M., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A. & Dobson, R., Jul 2012, In : Alzheimer's & Dementia. 8, 4, Supplement, p. P101-P101 1 p., O1-09-03.

    Research output: Contribution to journalMeeting abstract

  26. Identification of blood-based complement biomarkers in Alzheimer's disease

    Aiyaz, M., Hakobyan, S., Harris, C., Stretton, A., Baird, A., Ashton, N., Hye, A., Riddoch-Contreras, J., Settlecker, M., Dobson, R., Morgan, P. & Lovestone, S., Jul 2012, In : Alzheimer's & Dementia. 8, 4, Supplement, p. P283-P283 1 p., P2-059.

    Research output: Contribution to journalMeeting abstract

  27. Multiplexed analysis of plasma in Alzheimer's disease

    Hye, A., Riddoch-Contreras, J., Baird, A., Ashton, N., Sattlecker, M., Dobson, R., Ward, M., Pike, I., Thambisetty, M. & Lovestone, S., Jul 2012, In : Alzheimer's & Dementia. 8, 4, Supplement, p. P78-P79 2 p., S1-02-01.

    Research output: Contribution to journalMeeting abstract

  28. Predicting the progression of Alzheimer's disease by plasma-based biomarkers

    Riddoch-Contreras, J., Hye, A., Baird, A., Ashton, N., Sattlecker, M., Dobson, R., Ward, M., Pike, I. & Lovestone, S., Jul 2012, In : Alzheimer's & Dementia. 8, 4, Supplement, p. P282 1 p., P2-054.

    Research output: Contribution to journalMeeting abstract

  29. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial

    Chappell, L. C., Gurung, V., Seed, P. T., Chambers, J., Williamson, C., Thornton, J. G. & PITCH Study Consortium, 13 Jun 2012, In : BMJ. 344, e3799.

    Research output: Contribution to journalArticle

  30. What are the characteristics of people who attend emergency departments with epilepsy?

    Ridsdale, L., Noble, A., Goldstein, L., McCrone, P. & Seed, P., Jun 2012, In : Journal of Neurology. 259, p. S14-S14 1 p.

    Research output: Contribution to journalMeeting abstract

  31. The development and validation of a prediction tool for spontaneous preterm birth incorporating fetal fibronectin and cervical length

    Abbott, D., Smout, E., Foster, C., Van der Westhuizen, M., Seed, P. & Shennan, A. H., May 2012, In : Bjog-An international journal of obstetrics and gynaecology. 119, 6, p. e1-e1 1 p.

    Research output: Contribution to journalMeeting abstract

  32. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia

    Proitsi, P., Lupton, M. K., Reeves, S. J., Hamilton, G., Archer, N., Martin, B. M., Iyegbe, C., Hollingworth, P., Lawlor, B., Gill, M., Brayne, C., Rubinsztein, D. C., Owen, M. J., Williams, J., Lovestone, S. & Powell, J. F., 1 Apr 2012, In : Neurobiology of Aging. 33, 4, p. 791 - 803 13 p.

    Research output: Contribution to journalArticle

  33. Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome

    Breen, K. A., Seed, P., Parmar, K., Moore, G. W., Stuart-Smith, S. E. & Hunt, B. J., Mar 2012, In : Thrombosis and Haemostasis. 107, 3, p. 423 - 429 7 p.

    Research output: Contribution to journalArticle

  34. Complement activation as a biomarker for Alzheimer's disease

    Aiyaz, M., Lupton, M. K., Proitsi, P., Powell, J. F. & Lovestone, S., Feb 2012, In : Immunobiology. 217, 2, p. 204 - 215 12 p.

    Research output: Contribution to journalLiterature review

  35. Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

    Thambisetty, M., An, Y., Kinsey, A., Koka, D., Saleem, M., Guentert, A., Kraut, M., Ferrucci, L., Davatzikos, C., Lovestone, S. & Resnick, S. M., 2 Jan 2012, In : NeuroImage. 59, 1, p. 212-217 6 p.

    Research output: Contribution to journalArticle

  36. Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease

    Whitehead, D., Tunnard, C., Hurt, C., Wahlund, L. O., Mecocci, P., Tsolaki, M., Vellas, B., Spenger, C., Ktoszewska, I., Soininen, H., Cromb, D., Lovestone, S. & Simmons, A., Jan 2012, In : International Psychogeriatrics. 24, 1, p. 99 - 107 9 p.

    Research output: Contribution to journalArticle

  37. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood

    Lunnon, K., Ibrahim, Z., Proitsi, P., Lourdusamy, A., Newhouse, S., Sattlecker, M., Furney, S., Saleem, M., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Coppola, G., Geschwind, D., Simmons, A., Lovestone, S., Dobson, R., Hodges, A. & AddNeuroMed Consortium, 2012, In : JOURNAL OF ALZHEIMERS DISEASE. 30, 3, p. 685-710 26 p.

    Research output: Contribution to journalArticle

  38. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

    Gerrish, A., Russo, G., Richards, A., Moskvina, V., Ivanov, D., Harold, D., Sims, R., Abraham, R., Hollingworth, P., Chapman, J., Hamshere, M., Pahwa, J. S., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J. & 73 others, Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Johnston, J. A., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Kölsch, H., Heun, R., Schürmann, B., van den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Davies, G., Harris, S. E., Starr, J. M., Deary, I. J., Al-Chalabi, A., Shaw, C. E., Tsolaki, M., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K-H., Klopp, N., Wichmann, H-E., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Jones, L., Holmans, P. A., O'Donovan, M. C., Owen, M. J. & Williams, J., 2012, In : JOURNAL OF ALZHEIMERS DISEASE. 28, 2, p. 377-387 11 p.

    Research output: Contribution to journalArticle

  39. 2011
  40. Role of oxidative stress and antioxidant supplementation in pregnancy disorders

    Poston, L., Igosheva, N., Mistry, H. D., Seed, P. T., Shennan, A. H., Rana, S., Karumanchi, S. A. & Chappell, L. C., 1 Dec 2011, In : American Journal of Clinical Nutrition. 94, 6 Suppl, p. 1980S-1985S

    Research output: Contribution to journalArticle

  41. Biomarkers for Alzheimer's disease therapeutic trials

    Hampel, H., Wilcock, G., Andrieu, S., Aisen, P., Blennow, K., Broich, K., Carrillo, M., Fox, N. C., Frisoni, G. B., Isaac, M., Lovestone, S., Nordberg, A., Prvulovic, D., Sampaio, C., Scheltens, P., Weiner, M., Winblad, B., Coley, N. & Vellas, B., Dec 2011, In : Progress in Neurobiology. 95, 4, p. 579 - 593 15 p.

    Research output: Contribution to journalLiterature review

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