King's College London

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Research Outputs

  1. 2012
  2. Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

    Greco, I., Day, N., Riddoch-Contreras, J., Reed, J., Soininen, H., Kloszewska, I., Tsolaki, M., Vellas, B., Spenger, C., Mecocci, P., Wahlund, L-O., Simmons, A., Barnes, J. & Lovestone, S., 31 Oct 2012, In : Journal Of Translational Medicine. 10, 10 p., 217.

    Research output: Contribution to journalArticle

  3. Managing hypertension in general practice: a cross-sectional study of treatment and ethnicity

    Schofield, P., Baawuah, F., Seed, P. T. & Ashworth, M., Oct 2012, In : British Journal of General Practice. 62, 603, p. e703-e709 7 p., N/A.

    Research output: Contribution to journalArticle

  4. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

    Mangialasche, F., Xu, W., Kivipelto, M., Costanzi, E., Ercolani, S., Pigliautile, M., Cecchetti, R., Baglioni, M., Simmons, A., Soininen, H., Tsolaki, M., Kloszewska, I., Vellas, B., Lovestone, S., Mecocci, P. & AddNeuroMed Consortium, Oct 2012, In : Neurobiology of Aging. 33, 10, p. 2282-2290 9 p.

    Research output: Contribution to journalArticle

  5. Plasma based markers of [11C] PiB-PET brain amyloid burden

    Kiddle, S. J., Thambisetty, M., Simmons, A., Riddoch-Contreras, J., Hye, A., Westman, E., Pike, I., Ward, M., Johnston, C., Lupton, M. K., Lunnon, K., Soininen, H., Kloszewska, I., Tsolaki, M., Vellas, B., Mecocci, P., Lovestone, S., Newhouse, S. & Dobson, R., 24 Sep 2012, In : PL o S One . 7, 9, 10 p., e44260.

    Research output: Contribution to journalArticle

  6. Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis

    Liu, Y., Julkunen, V., Paajanen, T., Westman, E., Wahlund, L-O., Aitken, A., Sobow, T., Mecocci, P., Tsolaki, M., Vellas, B., Muehlboeck, S., Spenger, C., Lovestone, S., Simmons, A., Soininen, H. & AddNeuroMed Consortium, Sep 2012, In : Neuroradiology. 54, 9, p. 929-938 10 p.

    Research output: Contribution to journalArticle

  7. Identification of cis-regulatory variation influencing protein abundance levels in human plasma

    Lourdusamy, A., Newhouse, S., Lunnon, K., Proitsi, P., Powell, J., Hodges, A., Nelson, S. K., Stewart, A., Williams, S., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S., Dobson, R. & Consortium, A., 15 Aug 2012, In : Human Molecular Genetics. 21, 16, p. 3719-3726 8 p.

    Research output: Contribution to journalArticle

  8. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimers diseases

    Coppola, G., Chinnathambi, S., Lee, J. J., Dombroski, B. A., Baker, M. C., Soto-Ortolaza, A. I., Lee, S. E., Klein, E., Huang, A. Y., Sears, R., Lane, J. R., Karydas, A. M., Kenet, R. O., Biernat, J., Wang, L-S., Cotman, C. W., DeCarli, C. S., Levey, A. I., Ringman, J. M., Mendez, M. F. & 31 others, Chui, H. C., Le Ber, I., Brice, A., Lupton, M. K., Preza, E., Lovestone, S., Powell, J., Graff-Radford, N., Petersen, R. C., Boeve, B. F., Lippa, C. F., Bigio, E. H., Mackenzie, I., Finger, E., Kertesz, A., Caselli, R. J., Gearing, M., Juncos, J. L., Ghetti, B., Spina, S., Bordelon, Y. M., Tourtellotte, W. W., Frosch, M. P., Vonsattel, J. P. G., Zarow, C., Beach, T. G., Albin, R. L., Lieberman, A. P., Lee, V. M., Trojanowski, J. Q. & Alzheimer's Dis Genetics Consortiu, 1 Aug 2012, In : Human Molecular Genetics. 21, 15, p. 3500-3512 13 p., dds161.

    Research output: Contribution to journalArticle

  9. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation

    Proitsi, P., Lupton, M. K., Dudbridge, F., Tsolaki, M., Hamilton, G., Daniilidou, M., Pritchard, M., Lord, K., Martin, B. M., Craig, D., Todd, S., McGuinness, B., Hollingworth, P., Harold, D., Kloszewska, I., Soininen, H., Mecocci, P., Velas, B., Gill, M., Lawlor, B. & 6 others, Rubinsztein, D. C., Brayne, C., Passmore, P. A., Williams, J., Lovestone, S. & Powell, J. F., Aug 2012, In : Neurobiology of Aging. 33, 8, p. 1843.e9-1843.e17 9 p., 1843.

    Research output: Contribution to journalArticle

  10. Genetic variants influencing human aging from late-onset Alzheimertextquotesingles disease (LOAD) genome-wide association studies (GWAS)

    Shi, H., Belbin, O., Medway, C., Brown, K., Kalsheker, N., Carrasquillo, M., Proitsi, P., Powell, J., Lovestone, S., Goate, A., Younkin, S., Passmore, P. & Morgan, K., Aug 2012, In : Neurobiology of Aging. 33, 8, p. 1849.e5-1849.e18 14 p., 1849.

    Research output: Contribution to journalArticle

  11. Plasma biomarkers for Alzheimer's disease: much needed but tough to find

    Bazenet, C. & Lovestone, S., Aug 2012, In : Biomarkers in Medicine. 6, 4, p. 441-454 14 p.

    Research output: Contribution to journalLiterature review

  12. Ageing Increases Vulnerability to A beta 42 Toxicity in Drosophila

    Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S. & Partridge, L., 12 Jul 2012, In : PL o S One . 7, 7, p. - 11 p., e40569.

    Research output: Contribution to journalArticle

  13. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial

    Chappell, L. C., Gurung, V., Seed, P. T., Chambers, J., Williamson, C., Thornton, J. G. & PITCH Study Consortium, 13 Jun 2012, In : BMJ. 344, e3799.

    Research output: Contribution to journalArticle

  14. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia

    Proitsi, P., Lupton, M. K., Reeves, S. J., Hamilton, G., Archer, N., Martin, B. M., Iyegbe, C., Hollingworth, P., Lawlor, B., Gill, M., Brayne, C., Rubinsztein, D. C., Owen, M. J., Williams, J., Lovestone, S. & Powell, J. F., 1 Apr 2012, In : Neurobiology of Aging. 33, 4, p. 791 - 803 13 p.

    Research output: Contribution to journalArticle

  15. Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome

    Breen, K. A., Seed, P., Parmar, K., Moore, G. W., Stuart-Smith, S. E. & Hunt, B. J., Mar 2012, In : Thrombosis and Haemostasis. 107, 3, p. 423 - 429 7 p.

    Research output: Contribution to journalArticle

  16. Complement activation as a biomarker for Alzheimer's disease

    Aiyaz, M., Lupton, M. K., Proitsi, P., Powell, J. F. & Lovestone, S., Feb 2012, In : Immunobiology. 217, 2, p. 204 - 215 12 p.

    Research output: Contribution to journalLiterature review

  17. Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

    Thambisetty, M., An, Y., Kinsey, A., Koka, D., Saleem, M., Guentert, A., Kraut, M., Ferrucci, L., Davatzikos, C., Lovestone, S. & Resnick, S. M., 2 Jan 2012, In : NeuroImage. 59, 1, p. 212-217 6 p.

    Research output: Contribution to journalArticle

  18. Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease

    Whitehead, D., Tunnard, C., Hurt, C., Wahlund, L. O., Mecocci, P., Tsolaki, M., Vellas, B., Spenger, C., Ktoszewska, I., Soininen, H., Cromb, D., Lovestone, S. & Simmons, A., Jan 2012, In : International Psychogeriatrics. 24, 1, p. 99 - 107 9 p.

    Research output: Contribution to journalArticle

  19. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood

    Lunnon, K., Ibrahim, Z., Proitsi, P., Lourdusamy, A., Newhouse, S., Sattlecker, M., Furney, S., Saleem, M., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Coppola, G., Geschwind, D., Simmons, A., Lovestone, S., Dobson, R., Hodges, A. & AddNeuroMed Consortium, 2012, In : JOURNAL OF ALZHEIMERS DISEASE. 30, 3, p. 685-710 26 p.

    Research output: Contribution to journalArticle

  20. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

    Gerrish, A., Russo, G., Richards, A., Moskvina, V., Ivanov, D., Harold, D., Sims, R., Abraham, R., Hollingworth, P., Chapman, J., Hamshere, M., Pahwa, J. S., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J. & 73 others, Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Johnston, J. A., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Kölsch, H., Heun, R., Schürmann, B., van den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Davies, G., Harris, S. E., Starr, J. M., Deary, I. J., Al-Chalabi, A., Shaw, C. E., Tsolaki, M., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K-H., Klopp, N., Wichmann, H-E., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Jones, L., Holmans, P. A., O'Donovan, M. C., Owen, M. J. & Williams, J., 2012, In : JOURNAL OF ALZHEIMERS DISEASE. 28, 2, p. 377-387 11 p.

    Research output: Contribution to journalArticle

  21. 2011
  22. Role of oxidative stress and antioxidant supplementation in pregnancy disorders

    Poston, L., Igosheva, N., Mistry, H. D., Seed, P. T., Shennan, A. H., Rana, S., Karumanchi, S. A. & Chappell, L. C., 1 Dec 2011, In : American Journal of Clinical Nutrition. 94, 6 Suppl, p. 1980S-1985S

    Research output: Contribution to journalArticle

  23. Biomarkers for Alzheimer's disease therapeutic trials

    Hampel, H., Wilcock, G., Andrieu, S., Aisen, P., Blennow, K., Broich, K., Carrillo, M., Fox, N. C., Frisoni, G. B., Isaac, M., Lovestone, S., Nordberg, A., Prvulovic, D., Sampaio, C., Scheltens, P., Weiner, M., Winblad, B., Coley, N. & Vellas, B., Dec 2011, In : Progress in Neurobiology. 95, 4, p. 579 - 593 15 p.

    Research output: Contribution to journalLiterature review

  24. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

    Sims, R., Dwyer, S., Harold, D., Gerrish, A., Hollingworth, P., Chapman, J., Jones, N., Abraham, R., Ivanov, D., Pahwa, J. S., Moskvina, V., Dowzell, K., Thomas, C., Stretton, A., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C. & 29 others, Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuiness, B., Todd, S., Johnston, J. A., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Jones, L., Holmans, P. A., O'Donovan, M., Owen, M. J. & Williams, J., Dec 2011, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 156B, 7, p. 764-71 8 p.

    Research output: Contribution to journalArticle

  25. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

    Furney, S. J., Simmons, A., Breen, G., Pedroso, I., Lunnon, K., Proitsi, P., Hodges, A., Powell, J., Wahlund, L-O., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Spenger, C., Lathrop, M., Shen, L., Kim, S., Saykin, A. J., Weiner, M. W. & 2 others, Lovestone, S. & AddNeuroMed Consortium, Alzheimer's Dis Neuroimaging, Nov 2011, In : Molecular Psychiatry. 16, 11, p. 1130-1138 9 p.

    Research output: Contribution to journalArticle

  26. AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America

    Westman, E., Simmons, A., Muehlboeck, J-S., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., Weiner, M. W., Lovestone, S., Spenger, C., Wahlund, L-O., AddNeuroMed Consortium & Alzheimer's Dis Neuroimaging Initi, 1 Oct 2011, In : NeuroImage. 58, 3, p. 818-828 11 p.

    Research output: Contribution to journalArticle

  27. Hippocampal Proton MR Spectroscopy in Early Alzheimer's Disease and Mild Cognitive Impairment

    Foy, C. M. L., Daly, E. M., Glover, A., O'Gorman, R., Simmons, A., Murphy, D. G. M. & Lovestone, S., Oct 2011, In : Brain Topography. 24, 3-4, p. 316 - 322 7 p.

    Research output: Contribution to journalArticle

  28. Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood

    Matthews, P. A., Samuelsson, A-M., Seed, P., Pombo, J., Oben, J. A., Poston, L. & Taylor, P. D., Aug 2011, In : The Journal of Physiology. 589, 16, p. 3969 - 3981 13 p.

    Research output: Contribution to journalArticle

  29. A genotype risk score based on Type 2 diabetes risk factors is associated with lower risk for Alzheimertextquotesingles disease in APOE e4 carriers

    Proitsi, P., Lupton, M., Tsolaki, M., Daniilidou, M., Soininen, H., Vellas, B., Kloszewska, I., Mecocci, P., Passmore, P., Williams, J. & Lovestone, S., 1 Jul 2011, In : Alzheimer's & Dementia. 7, 4 , p. e28-e29

    Research output: Contribution to journalArticle

  30. Genetic Variants Influencing Human Longevity from Late-Onset Alzheimer's Disease (LOAD) Genome-Wide Association Studies (GWAS)

    Shi, H., Medway, C., Brown, K., Kalsheker, N., Goate, A., Proitsi, P., Powell, J., Lovestone, S., Carrasquillo, M. & Younkin, S., 1 Jul 2011, In : Alzheimer's & Dementia. 7, 4, p. S195

    Research output: Contribution to journalArticle

  31. Apathy and cortical atrophy in Alzheimer's disease

    Tunnard, C., Whitehead, D., Hurt, C., Wahlund, L. O., Mecocci, P., Tsolaki, M., Vellas, B., Spenger, C., Kloszewska, I., Soininen, H., Lovestone, S. & Simmons, A., Jul 2011, In : International Journal of Geriatric Psychiatry. 26, 7, p. 741 - 748 8 p.

    Research output: Contribution to journalArticle

  32. Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study

    Liu, Y., Paajanen, T., Zhang, Y., Westman, E., Wahlund, L-O., Simmons, A., Tunnard, C., Sobow, T., Mecocci, P., Tsolaki, M., Vellas, B., Muehlboeck, S., Evans, A., Spenger, C., Lovestone, S. & Soininen, H., Jul 2011, In : Neurobiology of Aging. 32, 7, p. 1198 - 1206 9 p.

    Research output: Contribution to journalArticle

  33. Pregnancy Outcome in Women with Chronic Kidney Disease: A Prospective Cohort Study

    Bramham, K., Briley, A. L., Seed, P. T., Poston, L., Shennan, A. H. & Chappell, L. C., Jul 2011, In : Reproductive Sciences. 18, 7, p. 623 - 630 8 p.

    Research output: Contribution to journalArticle

  34. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

    Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J-C., Carrasquillo, M. M., Abraham, R., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Jones, N., Stretton, A., Thomas, C., Richards, A., Ivanov, D., Widdowson, C., Chapman, J., Lovestone, S., Powell, J. & 152 others, Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., Smith, A. D., Beaumont, H., Warden, D., Wilcock, G., Love, S., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Hardy, J., Mead, S., Fox, N. C., Rossor, M., Collinge, J., Maier, W., Jessen, F., Ruether, E., Schuermann, B., Heun, R., Koelsch, H., van den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Froelich, L., Hampel, H., Gallacher, J., Huell, M., Rujescu, D., Giegling, I., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Sleegers, K., Bettens, K., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Tsolaki, M., Singleton, A. B., Guerreiro, R., Muehleisen, T. W., Noethen, M. M., Moebus, S., Joeckel, K-H., Klopp, N., Wichmann, H-E., Pankratz, V. S., Sando, S. B., Aasly, J. O., Barcikowska, M., Wszolek, Z. K., Dickson, D. W., Graff-Radford, N. R., Petersen, R. C., van Duijn, C. M., Breteler, M. M. B., Ikram, M. A., DeStefano, A. L., Fitzpatrick, A. L., Lopez, O., Launer, L. J., Seshadri, S., Berr, C., Campion, D., Epelbaum, J., Dartigues, J-F., Tzourio, C., Alperovitch, A., Lathrop, M., Feulner, T. M., Friedrich, P., Riehle, C., Krawczak, M., Schreiber, S., Mayhaus, M., Nicolhaus, S., Wagenpfeil, S., Steinberg, S., Stefansson, H., Stefansson, K., Snaedal, J., Bjornsson, S., Jonsson, P. V., Chouraki, V., Genier-Boley, B., Hiltunen, M., Soininen, H., Combarros, O., Zelenika, D., Delepine, M., Bullido, M. J., Pasquier, F., Mateo, I., Frank-Garcia, A., Porcellini, E., Hanon, O., Coto, E., Alvarez, V., Bosco, P., Siciliano, G., Mancuso, M., Panza, F., Solfrizzi, V., Nacmias, B., Sorbi, S., Bossu, P., Piccardi, P., Arosio, B., Annoni, G., Seripa, D., Pilotto, A., Scarpini, E., Galimberti, D., Brice, A., Hannequin, D., Licastro, F., Jones, L., Holmans, P. A., Jonsson, T., Riemenschneider, M., Morgan, K., Younkin, S. G., Owen, M. J., O'Donovan, M., Amouyel, P. & Williams, J., May 2011, In : Nature Genetics. 43, 5, p. 429-435 7 p.

    Research output: Contribution to journalArticle

  35. A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD)

    Proitsi, P., Hamilton, G., Tsolaki, M., Lupton, M., Daniilidou, M., Hollingworth, P., Archer, N., Foy, C., Stylios, F., McGuinness, B., Todd, S., Lawlor, B., Gill, M., Brayne, C., Rubinsztein, D. C., Owen, M., Williams, J., Craig, D., Passmore, P., Lovestone, S. & 1 others, Powell, J. F., Mar 2011, In : Neurobiology of Aging. 32, 3, p. 434 - 442 9 p.

    Research output: Contribution to journalArticle

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