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Research Outputs

  1. 2016
  2. Midwife-led continuity models versus other models of care for childbearing women

    Sandall, J., Soltani, H., Gates, S., Shennan, A. H. & Devane, D., 28 Apr 2016, In : Cochrane Database of Systematic Reviews. 2015, 9, p. 1-122 CD004667.

    Research output: Contribution to journalLiterature review

  3. A clinical opinion on how to manage the risk of preterm birth in twins based on literature review

    Collins, A. & Shennan, A., 2 Apr 2016, In : The Journal of Maternal-Fetal & Neonatal Medicine. 29, 7, p. 1125-1130 6 p.

    Research output: Contribution to journalReview article

  4. Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

    Abu-Hayyeh, S., Ovadia, C., Lieu, T., Jensen, D. D., Chambers, J., Dixon, P. H., Lövgren-Sandblom, A., Bolier, R., Tolenaars, D., Kremer, A. E., Syngelaki, A., Noori, M., Williams, D., Marin, J. J. G., Monte, M. J., Nicolaides, K. H., Beuers, U., Oude-Elferink, R., Seed, P. T., Chappell, L. & 3 others, Marschall, H-U., Bunnett, N. W. & Williamson, C., Apr 2016, In : Hepatology. 63, 4

    Research output: Contribution to journalArticle

  5. The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

    Krais, A. M., Speksnijder, E. N., Melis, J. P. M., Indra, R., Moserova, M., Godschalk, R. W., van Schooten, F-J., Seidel, A., Kopka, K., Schmeiser, H. H., Stiborova, M., Phillips, D. H., Luijten, M. & Arlt, V. M., Apr 2016, In : Archives of Toxicology. 90, 4, p. 839-851 13 p.

    Research output: Contribution to journalArticle

  6. Vital Sign Prediction of Adverse Maternal Outcomes in Women with Hypovolemic Shock: The Role of Shock Index

    El Ayadi, A. M., Nathan, H. L., Seed, P. T., Butrick, E. A., Hezelgrave, N. L., Shennan, A. H. & Miller, S., 22 Feb 2016, In : PLoS ONE. 11, 2, p. e0148729

    Research output: Contribution to journalArticle

  7. Metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and DNA adduct formation depends on p53: studies in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

    Krais, A. M., Speksnijder, E. N., Melis, J. P. M., Singh, R., Caldwell, A., Gamboa da Costa, G., Luijten, M., Phillips, D. H. & Arlt, V. M., 15 Feb 2016, In : International Journal of Cancer. 138, 4, p. 976–982

    Research output: Contribution to journalArticle

  8. Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

    Wohak, L., Krais, A. M., Kucab, J. E., Stertmann, J., Ovrebø, S., Seidel, A., Phillips, D. H. & Arlt, V. M., 1 Feb 2016, In : Archives of Toxicology. 90, 2, p. 291-304 14 p.

    Research output: Contribution to journalArticle

  9. Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women

    Hezelgrave Elliott, N., Abbott, D. S., Radford, S. K., Seed, P. T., Girling, J. C., Filmer, J., Tribe, R. M. & Shennan, A. H., 1 Feb 2016, In : Obstetrics and Gynecology. 127, 2, p. 255-263 9 p.

    Research output: Contribution to journalArticle

  10. Quantitative fetal fibronectin to predict spontaneous preterm birth: A review

    Hezelgrave, N. L. & Shennan, A. H., 1 Jan 2016, In : BMC Women's Health. 12, 1, p. 121-128 8 p.

    Research output: Contribution to journalArticle

  11. Transcriptional profiling of dibenzo[def, p]chrysene-induced spleen atrophy provides mechanistic insights into its immunotoxicity in mutamouse

    Chepelev, N. L., Long, A. S., Williams, A., Kuo, B., Gagné, R., Kennedy, D. A., Phillips, D. H., Arlt, V. M., White, P. A. & Yauk, C. L., 1 Jan 2016, In : Toxicological Sciences. 149, 1, p. 251-268 18 p.

    Research output: Contribution to journalArticle

  12. 2015
  13. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

    Kucab, J. E., Zwart, E. P., van Steeg, H., Luijten, M., Schmeiser, H. H., Phillips, D. H. & Arlt, V. M., 8 Dec 2015, In : DNA REPAIR.

    Research output: Contribution to journalArticle

  14. Antenatal steroids for fetal lung maturity: Time to target more frequent doses to fewer women?

    Freeman, C. I., Hezelgrave, N. L. & Shennan, A. H., Dec 2015, In : Obstetric Medicine. 8, 4, p. 172-176 5 p.

    Research output: Contribution to journalArticle

  15. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

    Coomarasamy, A., Williams, H., Truchanowicz, E., Seed, P. T., Small, R., Quenby, S., Gupta, P., Dawood, F., Koot, Y. E. M., Bender Atik, R., Bloemenkamp, K. W. M., Brady, R., Briley, A. L., Cavallaro, R., Cheong, Y. C., Chu, J. J., Eapen, A., Ewies, A., Hoek, A., Kaaijk, E. M. & 15 others, Koks, C. A. M., Li, T-C., MacLean, M., Mol, B. W., Moore, J., Ross, J. A., Sharpe, L., Stewart, J., Vaithilingam, N., Farquharson, R. G., Kilby, M. D., Khalaf, Y., Goddijn, M., Regan, L. & Rai, R., 26 Nov 2015, In : New England Journal of Medicine. 373, 22, p. 2141-8 8 p.

    Research output: Contribution to journalArticle

  16. The genome as a record of environmental exposure

    Nik-Zainal, S., Kucab, J. E., Morganella, S., Glodzik, D., Alexandrov, L. B., Arlt, V. M., Weninger, A., Hollstein, M., Stratton, M. R. & Phillips, D. H., Nov 2015, In : Mutagenesis. 30, 6, p. 763-770 8 p.

    Research output: Contribution to journalArticle

  17. Moving beyond silos: How do we provide distributed personalized medicine to pregnant women everywhere at scale? Insights from PRE-EMPT

    von Dadelszen, P., Magee, L. A., Payne, B. A., Dunsmuir, D. T., Drebit, S., Dumont, G. A., Miller, S., Norman, J., Pyne-Mercier, L., Shennan, A. H., Donnay, F., Bhutta, Z. A. & Ansermino, J. M., 1 Oct 2015, In : International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 131, p. S10-S15

    Research output: Contribution to journalArticle

  18. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial

    Poston, L., Bell, R., Croker, H., Flynn, A. C., Godfrey, K. M., Goff, L., Hayes, L., Khazaezadeh, N., Nelson, S. M., Oteng-Ntim, E., Pasupathy, D., Patel, N., Robson, S. C., Sandall, J., Sanders, T. A. B., Sattar, N., Seed, P. T., Wardle, J., Whitworth, M. K., Briley, A. L. & 1 others, UPBEAT Trial Consortium, Oct 2015, In : The Lancet Diabetes and Endocrinology. 3, 10, p. 767-777 11 p.

    Research output: Contribution to journalArticle

  19. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development

    Perera, F., Phillips, D. H., Wang, Y., Roen, E., Herbstman, J., Rauh, V., Wang, S. & Tang, D., 21 Aug 2015, In : Environmental Research. 142, p. 602-608 7 p., 6575.

    Research output: Contribution to journalArticle

  20. Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height

    Griffin, M., Seed, P. T., Webster, L., Myers, J., Mackillop, L., Simpson, N., Anumba, D., Khalil, A., Denbow, M., Sau, A., Hinshaw, K., Von Dadelszen, P., Benton, S., Girling, J., Redman, C. W. G., Chappell, L. C. & Shennan, A. H., 1 Aug 2015, In : Ultrasound in Obstetrics and Gynecology. 46, 2, p. 182-190 9 p.

    Research output: Contribution to journalArticle

  21. Relevance of individual participant data meta-analysis for studies in obstetrics: Delivery versus expectant monitoring for hypertensive disorders of pregnancy

    Broekhuijsen, K., Bernardes, T., Van Baaren, G. J., Tajik, P., Novikova, N., Thangaratinam, S., Boers, K., Koopmans, C. M., Wallace, K., Shennan, A., Langenveld, J., Groen, H., Van Den Berg, P. P., Mol, B. W. J. & Franssen, M. T. M., 1 Aug 2015, In : European Journal of Obstetrics Gynecology and Reproductive Biology. 191, p. 80-83 4 p.

    Research output: Contribution to journalReview article

  22. A mismatch between population health literacy and the complexity of health information: An observational study

    Rowlands, G., Protheroe, J., Winkley, J., Richardson, M., Seed, P. T. & Rudd, R., 1 Jun 2015, In : The British journal of general practice : the journal of the Royal College of General Practitioners. 65, 635, p. 379-386 8 p.

    Research output: Contribution to journalArticle

  23. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: Systematic review and meta-analysis

    Oteng-Ntim, E., Meeks, D., Seed, P. T., Webster, L., Howard, J., Doyle, P. & Chappell, L. C., 21 May 2015, In : Blood. 125, 21, p. 3316-3325 10 p.

    Research output: Contribution to journalArticle

  24. Tests to predict imminent delivery in threatened preterm labour

    Hezelgrave Elliott, N., Shennan, A. H. & David, A. L., 21 May 2015, In : BMJ (Clinical research ed.). 350, p. h2183

    Research output: Contribution to journalArticle

  25. RIPOSTE: A framework for improving the design and analysis of laboratory-based research

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Dawn Teare, M., 7 May 2015, In : eLife. 4, p. 1-27 27 p.

    Research output: Contribution to journalArticle

  26. Preeclampsia: An old disease with new tools for better diagnosis and risk management

    El Hassan, M. A., Diamandis, E. P., Karumanchi, S. A., Shennan, A. H. & Taylor, R. N., 1 May 2015, In : Clinical Chemistry. 61, 5, p. 694-698 5 p.

    Research output: Contribution to journalComment/debate

  27. Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk

    Abbott, D. S., Hezelgrave, N. L., Seed, P. T., Norman, J. E., David, A. L., Bennett, P. R., Girling, J. C., Chandirimani, M., Stock, S. J., Carter, J., Cate, R., Kurtzman, J., Tribe, R. M. & Shennan, A. H., 1 May 2015, In : Obstetrics and Gynecology. 125, 5, p. 1168-1176 9 p.

    Research output: Contribution to journalArticle

  28. The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Stiborova, M. & Phillips, D. H., 1 May 2015, In : Toxicology Research. 4, 3, p. 548-562 15 p.

    Research output: Contribution to journalLiterature review

  29. Variation in management of women with threatened preterm labour

    Stock, S. J., Morris, R. K., Chandiramani, M., Shennan, A. H. & Norman, J. E., 1 May 2015, In : ADC Fetal & Neonatal. 100, 3, p. F276

    Research output: Contribution to journalLetter

  30. Pulmonary inflammation impacts on CYP1A1-mediated respiratory tract DNA damage induced by the carcinogenic air pollutant benzo[a]pyrene

    Arlt, V. M., Krais, A., Godschalk, R. W., Riffo-Vasquez, Y., Mrizova, I., Roufosse, C. A., Corbin, C., Shi, Q., Frei, E., Stiborova, M., van Schooten, F-J., Phillips, D. H. & Spina, D., 23 Apr 2015, In : Toxicological sciences : an official journal of the Society of Toxicology. 146, 2, p. 213-225 13 p.

    Research output: Contribution to journalArticle

  31. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

    Kucab, J. E., van Steeg, H., Luijten, M., Schmeiser, H. H., White, P. A., Phillips, D. H. & Arlt, V. M., 1 Mar 2015, In : Mutation Research. 773, p. 48-62 15 p.

    Research output: Contribution to journalArticle

  32. Dalteparin for pregnant women with thrombophilia

    Hunt, B. J., Seed, P. T. & Lefkou, E., 21 Feb 2015, In : Lancet. 385, 9969, p. 689 1 p.

    Research output: Contribution to journalLiterature review

  33. Recent advances in the diagnosis and management of pre-eclampsia

    Duhig, K. E. & Shennan, A. H., 3 Feb 2015, In : F1000Prime Reports. 7, 24.

    Research output: Contribution to journalArticle

  34. Endothelial and platelet microparticles in patients with antiphospholipid antibodies

    Breen, K. A., Sanchez, K., Kirkman, N., Seed, P. T., Parmar, K., Moore, G. W. & Hunt, B. J., 1 Feb 2015, In : Thrombosis Research. 135, 2, p. 368-374 7 p.

    Research output: Contribution to journalArticle

  35. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

    Krais, A. M., Mühlbauer, K-R., Kucab, J. E., Chinbuah, H., Cornelius, M. G., Wei, Q-X., Hollstein, M., Phillips, D. H., Arlt, V. M. & Schmeiser, H. H., Feb 2015, In : Toxicology in Vitro. 29, 1, p. 34-43 10 p.

    Research output: Contribution to journalArticle

  36. Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop pre-eclampsia

    Mistry, H. D., Gill, C. A., Kurlak, L. O., Seed, P. T., Hesketh, J. E., Méplan, C., Schomburg, L., Chappell, L. C., Morgan, L., Poston, L. & on behalf of SCOPE consortium, 1 Jan 2015, In : Free Radical Biology and Medicine. 78, p. 147-155 9 p.

    Research output: Contribution to journalArticle

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