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Research Outputs

  1. 2022
  2. 2021
  3. The Effects of Acute Δ9-Tetrahydrocannabinol on Striatal Glutamatergic Function: A Proton Magnetic Resonance Spectroscopy Study

    Bloomfield, M. A. P., Petrilli, K., Lees, R., Hindocha, C., Beck, K., Turner, R. J., Onwordi, E. C., Rane, N., Lythgoe, D. J., Stone, J. M., Curran, H. V., Howes, O. D. & Freeman, T. P., Jun 2021, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 6, 6, p. 660-667 8 p.

    Research output: Contribution to journalArticlepeer-review

  4. Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study

    Rogdaki, M., Devroye, C., Ciampoli, M., Veronese, M., Ashok, A., McCutcheon, R. A., Jauhar, S., Bonoldi, I., Gudbrandsen, M., Daly, E., van Amelsvoort, T., Van Den Bree, M., Owen, M. J., Turkheimer, F., Papaleo, F. & Howes, O. D., 12 May 2021, (E-pub ahead of print) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  5. 2020
  6. The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders

    Cheng, P. W. C., Chang, W. C., Lo, G. G., Chan, K. W. S., Lee, H. M. E., Hui, L. M. C., Suen, Y. N., Leung, Y. L. E., Au Yeung, K. M. P., Chen, S., Mak, K. F. H., Sham, P. C., Santangelo, B., Veronese, M., Ho, C-L., Chen, Y. H. E. & Howes, O. D., 1 Oct 2020, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 45, 11, p. 1870-1876 7 p.

    Research output: Contribution to journalArticlepeer-review

  7. Dopamine dysregulation in psychotic relapse after antipsychotic discontinuation: an [18F]DOPA and [11C]raclopride PET study in first-episode psychosis

    Kim, S., Shin, S. H., Santangelo, B., Veronese, M., Kang, S. K., Lee, J. S., Cheon, G. J., Lee, W., Kwon, J. S., Howes, O. D. & Kim, E., 14 Sep 2020, (E-pub ahead of print) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  8. Variability in action selection relates to striatal dopamine 2/3 receptor availability in humans: A PET neuroimaging study using reinforcement learning and active inference models

    Adams, R. A., Moutoussis, M., Nour, M. M., Dahoun, T., Lewis, D., Illingworth, B., Veronese, M., Mathys, C., De Boer, L., Guitart-Masip, M., Friston, K. J., Howes, O. D. & Roiser, J. P., 18 May 2020, In: Cerebral Cortex. 30, 6, p. 3573-3589

    Research output: Contribution to journalArticlepeer-review

  9. Heterogeneity of Striatal Dopamine Function in Schizophrenia: Meta-analysis of Variance

    Brugger, S. P., Angelescu, I., Abi-Dargham, A., Mizrahi, R., Shahrezaei, V. & Howes, O. D., 1 Feb 2020, In: Biological psychiatry. 87, 3, p. 215-224 10 p.

    Research output: Contribution to journalArticlepeer-review

  10. 2019
  11. Disrupted-in-schizophrenia 1 functional polymorphisms and D2/D3 receptor availability: A [11C]-(+)-PHNO imaging study

    Dahoun, T., Nour, M. M., Adams, R. A., Trossbach, S., Lee, S. H., Patel, H., Curtis, C., Korth, C. & Howes, O. D., 1 Nov 2019, In: Genes, Brain and Behavior. 18, 8, e12596.

    Research output: Contribution to journalArticlepeer-review

  12. In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis

    METSY Group, 1 Oct 2019, In: JAMA Psychiatry. 76, 10, p. 1074-1084 11 p.

    Research output: Contribution to journalArticlepeer-review

  13. The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis

    McCutcheon, R. A., Pillinger, T., Mizuno, Y., Montgomery, A., Pandian, H., Vano, L., Marques, T. R. & Howes, O. D., 30 Aug 2019, In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  14. Cannabinoid 1 receptor levels and cognition in patients with first episode psychosis: a positron emission tomography study in two independent cohorts of patients

    Borgan, F., Laurikainen, H., Veronese, M., Reis Marques, T., Haaparanta-Solin, M., Solin, O., Dahoun, T., Rogdaki, M., Salokangas, R. KR., Karukivi, M., Di Forti, M., Turkheimer, F., Hietala, J. & Howes, O., 23 Apr 2019, (Accepted/In press) In: JAMA Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  15. Clinical guidance on the identification and management of treatment-resistant schizophrenia

    Kane, J. M., Agid, O., Baldwin, M. L., Howes, O., Lindenmayer, J. P., Marder, S., Olfson, M., Potkin, S. G. & Correll, C. U., 1 Mar 2019, In: Journal of Clinical Psychiatry. 80, 2, 18com12123.

    Research output: Contribution to journalArticlepeer-review

  16. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

    Erritzoe, D., Ashok, A. H., Searle, G. E., Colasanti, A., Turton, S., Lewis, Y., Huiban, M., Moz, S., Passchier, J., Saleem, A., Beaver, J., Lingford-Hughes, A., Nutt, D. J., Howes, O. D., Gunn, R. N., Knudsen, G. M. & Rabiner, E. A., 1 Jan 2019, In: Neuropsychopharmacology.

    Research output: Contribution to journalArticlepeer-review

  17. 2018
  18. Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study

    Kim, S., Jung, W. H., Howes, O. D., Veronese, M., Turkheimer, F. E., Lee, Y-S., Lee, J. S., Kim, E. & Kwon, J. S., 21 Nov 2018, (E-pub ahead of print) In: Psychological Medicine. p. 1-10 10 p.

    Research output: Contribution to journalArticlepeer-review

  19. Association of hippocampal glutamate levels with adverse outcomes in individuals at clinical high risk for psychosis

    Bossong, M. G., Antoniades, M., Azis, M., Samson, C. A., Quinn, B., Bonoldi, I., Modinos, G., Perez, J., Howes, O. D., Stone, J. M., Allen, P. & McGuire, P., 14 Nov 2018, In: JAMA Psychiatry. 76, 2, p. 199-207

    Research output: Contribution to journalArticlepeer-review

  20. Comment on " in Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates"

    McGinnity, C. J., Årstad, E., Beck, K., Brooks, D. J., Coles, J. P., Duncan, J. S., Galovic, M., Hinz, R., Hirani, E., Howes, O. D., Jones, P. A., Koepp, M. J., Luo, F., Riaño Barros, D. A., Singh, N., Trigg, W. & Hammers, A., 11 Oct 2018, (E-pub ahead of print) In: Acs chemical neuroscience. 0, 0

    Research output: Contribution to journalArticlepeer-review

  21. Correction: Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis

    Winton-Brown, T., Schmidt, A., Roiser, J. P., Howes, O. D., Egerton, A., Fusar-Poli, P., Bunzeck, N., Grace, A. A., Duzel, E., Kapur, S. & McGuire, P., 31 Aug 2018, In: Translational psychiatry. 8, 1, p. 170

    Research output: Contribution to journalArticlepeer-review

  22. Platform for systems medicine research and diagnostic applications in psychotic disorders—The METSY project

    Frank, E., Maier, D., Pajula, J., Suvitaival, T., Borgan, F., Butz-Ostendorf, M., Fischer, A., Hietala, J., Howes, O., Hyötyläinen, T., Janssen, J., Laurikainen, H., Moreno, C., Suvisaari, J., Van Gils, M. & Orešič, M., 1 Feb 2018, (E-pub ahead of print) In: European Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  23. Higher serotonin transporter availability in early-onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study

    Lee, J., Kim, B. H., Kim, E., Howes, O. D., Cho, K. I. K., Yoon, Y. B. & Kwon, J. S., 1 Jan 2018, In: Human Psychopharmacology. 33, 1, e2642.

    Research output: Contribution to journalArticlepeer-review

  24. 2017
  25. Impaired glucose homeostasis in first-episode schizophrenia: A systematic review and meta-analysis

    Pillinger, T., Beck, K., Gobjila, C., Donocik, J. G., Jauhar, S. & Howes, O. D., 1 Mar 2017, In: JAMA Psychiatry. 74, 3, p. 261-269 9 p.

    Research output: Contribution to journalArticlepeer-review

  26. 2016
  27. Fronto-limbic engagement during moral processing in stimulant users

    Blackwood, N. J. & Howes, O. D., 1 Sep 2016, In: Psychopharmacology. 233, 17, p. 3075-3076 2 p.

    Research output: Contribution to journalArticlepeer-review

  28. Regional Differences in Serotonin Transporter Occupancy by Escitalopram: An [(11)C]DASB PK-PD Study

    Kim, E., Howes, O. D., Kim, B-H., Chon, M-W., Seo, S., Turkheimer, F. E., Lee, J. S., Lee, Y-S. & Kwon, J. S., 24 Aug 2016, (E-pub ahead of print) In: Clinical Pharmacokinetics.

    Research output: Contribution to journalArticlepeer-review

  29. O Contexto Holandês-Africano: As Províncias Unidas Entre África e Brasil, 1600-1650”

    Green, T. & Domingues de Souza, C., 9 Aug 2016, In: Revista do Instituto Arqueológico, Histórico e Geográfico Pernambucano. 69, p. 41-86 46 p.

    Research output: Contribution to journalArticlepeer-review

  30. Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology

    Goodwin, G. M., Haddad, P. M., Ferrier, I. N., Aronson, J. K., Barnes, T. R. H., Cipriani, A., Coghill, D. R., Fazel, S., Geddes, J. R., Grunze, H., Holmes, E. A., Howes, O., Hudson, S., Hunt, N., Jones, I., MacMillan, I. C., McAllister-Williams, H., Miklowitz, D. R., Morriss, R., Munafò, M. & 7 others, Paton, C., Saharkian, B. J., Saunders, K. E. A., Sinclair, J. M. A., Taylor, D., Vieta, E. & Young, A. H., 1 Jun 2016, In: Journal of psychopharmacology (Oxford, England). 30, 6, p. 495-553 59 p.

    Research output: Contribution to journalArticlepeer-review

  31. 2015
  32. Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study

    Kim, E., Howes, O. D., Park, J. W., Kim, S. N., Shin, S. A., Kim, B. H., Turkheimer, F. E., Lee, Y. S. & Kwon, J. S., 1 Oct 2015, (Accepted/In press) In: Psychological Medicine. 10 p.

    Research output: Contribution to journalArticlepeer-review

  33. Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum

    Bossong, M., Mehta, M., van Berckel, B., Howes, O., Kahn, R. S. & Stokes, P., Aug 2015, In: Psychopharmacology. 232, 15, p. 2723-2729 7 p.

    Research output: Contribution to journalArticlepeer-review

  34. Treatment resistant or resistant to treatment? Antipsychotic plasma levels in patients with poorly controlled psychotic symptoms

    McCutcheon, R., Beck, K., Bloomfield, M. A. P., Marques, T. R., Rogdaki, M. & Howes, O. D., Aug 2015, In: Journal of psychopharmacology (Oxford, England). 29, 8, p. 892-7 6 p.

    Research output: Contribution to journalArticlepeer-review

  35. 2014
  36. The practical management of refractory schizophrenia: the Maudsley Treatment REview and Assessment Team service approach

    Beck, K., Mccutcheon, R., Bloomfield, M. A. P., Gaughran, F., Reis Marques, T., Maccabe, J., Selvaraj, S., Taylor, D. & Howes, O. D., Dec 2014, In: Acta Psychiatrica Scandinavica. 130, 6, p. 427-438 12 p.

    Research output: Contribution to journalArticlepeer-review

  37. Three Encounters with W.G. Sebald (February 1992-July 2013)

    Green, T., Sontag, S., Wertheimer, J. & Sheppard, R. (ed.), Dec 2014, In: JOURNAL OF EUROPEAN STUDIES. 44, 4, p. 378-414 37 p.

    Research output: Contribution to journalArticlepeer-review

  38. Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies

    Selvaraj, S., Arnone, D., Cappai, A. & Howes, O., Sep 2014, In: Neuroscience and biobehavioral reviews. 45, p. 233-45 13 p.

    Research output: Contribution to journalArticlepeer-review

  39. Cannabis use and transition to psychosis in people at ultra-high risk

    Valmaggia, L. R., Day, F. L., Jones, C., Bissoli, S., Pugh, C., Hall, D., Bhattacharyya, S., Howes, O., Stone, J., Fusar-Poli, P., Byrne, M. & Mcguire, P. K., Sep 2014, In: Psychological Medicine. 44, 12, p. 2503-2512 10 p.

    Research output: Contribution to journalArticlepeer-review

  40. Dopamine Function in Cigarette Smokers: an [(18)F]-DOPA PET Study

    Bloomfield, M. A. P., Pepper, F., Egerton, A., Demjaha, A., Tomasi, G., Mouchlianitis, E., Maximen, L., Veronese, M., Turkheimer, F., Selvaraj, S. & Howes, O., Sep 2014, In: Neuropsychopharmacology. 39, 10, p. 2397-2404 8 p.

    Research output: Contribution to journalArticlepeer-review

  41. Practitioner attitudes to clozapine initiation

    Gee, S., Vergunst, F., Howes, O. & Taylor, D., Jul 2014, In: Acta Psychiatrica Scandinavica. 130, 1, p. 16-24 9 p.

    Research output: Contribution to journalArticlepeer-review

  42. Neuropathological changes in the substantia nigra in schizophrenia but not depression

    Williams, M. R., Galvin, K., O'Sullivan, B., MacDonald, C. D., Ching, E. W. K., Turkheimer, F., Howes, O. D., Pearce, R. K. B., Hirsch, S. R. & Maier, M., 1 Jun 2014, In: European Archives Of Psychiatry And Clinical Neuroscience. 264, 4, p. 285-296 12 p.

    Research output: Contribution to journalArticlepeer-review

  43. The link between dopamine function and apathy in cannabis users: an [F-18]-DOPA PET imaging study

    Bloomfield, M. A. P., Morgan, C. J. A., Kapur, S., Curran, H. V. & Howes, O. D., Jun 2014, In: Psychopharmacology. 231, 11, p. 2251-2259 9 p.

    Research output: Contribution to journalArticlepeer-review

  44. Dopaminergic Function in Cannabis Users and Its Relationship to Cannabis-Induced Psychotic Symptoms

    Bloomfield, M. A. P., Morgan, C. J. A., Egerton, A., Kapur, S., Curran, H. V. & Howes, O. D., 15 Mar 2014, In: Biological psychiatry. 75, 6, p. 470-478 9 p.

    Research output: Contribution to journalArticlepeer-review

  45. Spatial working memory ability in individuals at ultra high risk for psychosis

    Goghari, V. M., Brett, C., Tabraham, P., Johns, L., Valmaggia, L., Broome, M., Woolley, J., Bramon, E., Howes, O., Byrne, M. & McGuire, P., Mar 2014, In: Journal of Psychiatric Research. 50, p. 100-105 6 p.

    Research output: Contribution to journalArticlepeer-review

  46. Dopaminergic basis of salience dysregulation in psychosis

    Winton-Brown, T., Fusar-Poli, P., Ungless, M. A. & Howes, O., Feb 2014, In: Trends in Neurosciences. 37, 2, p. 85-94 10 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  47. Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study

    Selvaraj, S., Mouchlianitis, E., Faulkner, P., Turkheimer, F., Cowen, P. J., Roiser, J. P. & Howes, O., 2014, (E-pub ahead of print) In: Biological psychiatry. 8 p.

    Research output: Contribution to journalArticlepeer-review

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