Howes, O & Onwordi, EC 2023, 'The Synaptic Hypothesis of Schizophrenia Version III: A Master Mechanism', Molecular Psychiatry.

Howes, OD, Cummings, C, Chapman, GE & Shatalina, E 2023, 'Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes', Neuropsychopharmacology, vol. 48, no. 1, pp. 151-167. https://doi.org/10.1038/s41386-022-01426-x

Butler, E, Pillinger, T, Brown, K, Borgan, F, Bowen, A, Beck, K, D'Ambrosio, E, Jauhar, S, Kaar, S, McCutcheon, R, Rogdaki, M, Gaughran, F, Maccabe, J, Ramsay, R, McCrone, P, Egerton, A & Howes, O 2022, 'Real-world clinical and cost-effectiveness of community clozapine initiation: mirror cohort study', British Journal of Psychiatry, vol. 221, no. 6, pp. 740-747. https://doi.org/10.1192/bjp.2022.47

Halff, E, Natesan, S, Bonsall, DR, Veronese, M, Garcia-Hidalgo, A, Kokkinou, M, Tang, S-P, Riggall , L, Gunn, R, Irvine, E, Withers, D, Wells, L & Howes, O 2022, 'Evaluation of intraperitoneal [¹⁸F]-FDOPA administration for micro-PET imaging in mice and assessment of the effect of sub-chronic ketamine dosing on dopamine synthesis capacity', Molecular Imaging.

Howes, OD & Shatalina, E 2022, 'Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance', Biological psychiatry, vol. 92, no. 6, pp. 501-513. https://doi.org/10.1016/j.biopsych.2022.06.017

Angelescu, I, Kaar, SJ, Marques, TR, Borgan, F, Veronesse, M, Sharman, A, Sajjala, A, Deakin, B, Hutchison, J, Large, C & Howes, OD 2022, 'The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [¹⁸F]-FDOPA imaging in schizophrenia', Journal of psychopharmacology (Oxford, England), vol. 36, no. 9, pp. 1061-1069. https://doi.org/10.1177/02698811221122031

Harvey, PD, Bosia, M, Cavallaro, R, Howes, OD, Kahn, RS, Leucht, S, Müller, DR, Penadés, R & Vita, A 2022, 'Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art', Schizophrenia Research: Cognition, vol. 29, 100249. https://doi.org/10.1016/j.scog.2022.100249

Beck, K, Arumuham, A, Brugger, S, McCutcheon, RA, Veronese, M, Santangelo, B, McGinnity, CJ, Dunn, J, Kaar, S, Singh, N, Pillinger, T, Borgan, F, Sementa, T, Neji, R, Jauhar, S, Aigbirhio, F, Boros, I, Turkheimer, F, Hammers, A, Lythgoe, D, Stone, J & Howes, OD 2022, 'The association between N-methyl-d-aspartate receptor availability and glutamate levels: A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls', Journal of psychopharmacology (Oxford, England), vol. 36, no. 9, pp. 1051-1060. https://doi.org/10.1177/02698811221099643

Rogeau, A, Nordio, G, Veronese, M, Brown, K, Nour, MM, Osugo, M, Jauhar, S, Howes, OD & McCutcheon, RA 2022, 'The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study', Molecular Psychiatry, vol. 27, no. 8, pp. 3493-3500. https://doi.org/10.1038/s41380-022-01596-6

D'Ambrosio, E, Pergola, G, Pardiñas, AF, Dahoun, T, Veronese, M, Sportelli, L, Taurisano, P, Griffiths, K, Jauhar, S, Rogdaki, M, Bloomfield, MAP, Froudist-Walsh, S, Walters, JTR, Blasi, G, Bertolino, A & Howes, O 2022, 'A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function', Scientific Reports, vol. 12, no. 1, 12610. https://doi.org/10.1038/s41598-022-16442-6

Shin, S, Jung, WH, McCutcheon, R, Veronese, M, Beck, K, Lee, JS, Lee, YS, Howes, OD, Kim, E & Kwon, JS 2022, 'The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An¹⁸F-DOPA PET and Diffusion Tensor Imaging Study in Treatment Responsive and Resistant Patients', Psychiatry Investigation, vol. 19, no. 7, pp. 570-579. https://doi.org/10.30773/pi.2022.0033

Griffiths, K, Egerton, A, Millgate, E, Anton, A, Barker, GJ, Deakin, B, Drake, R, Eliasson, E, Gregory, CJ, Howes, OD, Kravariti, E, Lawrie, SM, Lewis, S, Lythgoe, DJ, Murphy, A, McGuire, P, Semple, S, Stockton-Powdrell, C, Walters, JTR, Williams, SR & MacCabe, JH 2022, 'Impaired verbal memory function is related to anterior cingulate glutamate levels in schizophrenia: findings from the STRATA study', Schizophrenia, vol. 8, no. 1, 60, pp. 60. https://doi.org/10.1038/s41537-022-00265-5

Nour, MM, Beck, K, Liu, Y, Arumuham, A, Veronese, M, Howes, OD & Dolan, RJ 2022, 'Relationship Between Replay-Associated Ripples and Hippocampal N-Methyl-D-Aspartate Receptors: Preliminary Evidence From a PET-MEG Study in Schizophrenia', Schizophrenia Bulletin Open, vol. 3, no. 1, sgac044, pp. gac044. https://doi.org/10.1093/schizbullopen/sgac044

Howes, OD, Barnes, TRE, Lennox, BR, Markham, S & Natesan, S 2022, 'Time to re-evaluate the risks and benefits of valproate and a call for action', British Journal of Psychiatry. https://doi.org/10.1192/bjp.2022.94

Correll, CU, Agid, O, Crespo-Facorro, B, de Bartolomeis, A, Fagiolini, A, Seppälä, N & Howes, OD 2022, 'A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia', CNS Drugs, vol. 36, no. 7, pp. 659-679. https://doi.org/10.1007/s40263-022-00932-2

McCutcheon, RA, Pillinger, T, Efthimiou, O, Maslej, M, Mulsant, BH, Young, AH, Cipriani, A & Howes, OD 2022, 'Reappraising the variability of effects of antipsychotic medication in schizophrenia: a meta-analysis', World Psychiatry, vol. 21, no. 2, pp. 287-294. https://doi.org/10.1002/wps.20977

Carreira Figueiredo, I, Borgan, F, Pasternak, O, Turkheimer, F & Howes, O 2022, 'White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis', Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol. 47, no. 7, pp. 1413-1420. https://doi.org/10.1038/s41386-022-01272-x

Bloomfield, MAP, Yamamori, Y, Hindocha, C, Jones, APM, Yim, JLL, Walker, HR, Statton, B, Wall, MB, Lees, RH, Howes, OD, Curran, VH, Roiser, JP & Freeman, TP 2022, 'The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study', Psychopharmacology, vol. 239, no. 5, pp. 1539-1549. https://doi.org/10.1007/s00213-022-06070-3

Arumuham, A, O’Brien, O, Ahmad, Z, Nikbin, K & Howes, OD 2022, 'Low COVID-19 vaccination rates in people with severe mental illness and reasons for this: An out-patient study', Acta Psychiatrica Scandinavica, vol. 145, no. 4, pp. 416-418. https://doi.org/10.1111/acps.13400

Osimo, EF, Brugger, SP, Thomas, EL & Howes, OD 2022, 'A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia', NPJ SCHIZOPHRENIA, vol. 8, no. 1, 24. https://doi.org/10.1038/s41537-022-00233-z

Krajner, F, Hadaya, L, McQueen, G, Sendt, K-V, Gillespie, A, Avila, A, Lally, J, Hedges, M, Diederen, K, Howes, O, Barker, G, Lythgoe, D, Kempton, M, McGuire, P, Maccabe, J & Egerton, A 2022, 'Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia', NPJ SCHIZOPHRENIA, vol. 8, no. 1, 13. https://doi.org/10.1038/s41537-022-00230-2

Ribeiro, D, Hallett, W, Howes, O, McCutcheon, R, Nour, MM & Tavares, AAS 2022, 'Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [¹¹C]PHNO brain PET-MR studies', EJNMMI Research, vol. 12, no. 1, 11. https://doi.org/10.1186/s13550-022-00883-1

Manchia, M, Gathier, AW, Yapici-Eser, H, Schmidt, MV, de Quervain, D, van Amelsvoort, T, Bisson, JI, Cryan, JF, Howes, OD, Pinto, L, van der Wee, NJ, Domschke, K, Branchi, I & Vinkers, CH 2022, 'The impact of the prolonged COVID-19 pandemic on stress resilience and mental health: A critical review across waves', European Neuropsychopharmacology, vol. 55, pp. 22-83. https://doi.org/10.1016/j.euroneuro.2021.10.864

Lobo, MC, Whitehurst, TS, Kaar, SJ & Howes, OD 2022, 'New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics', Neuroscience and Biobehavioral Reviews, vol. 132, pp. 324-361. https://doi.org/10.1016/j.neubiorev.2021.11.032

Dedic, N, Dworak, H, Zeni, C, Rutigliano, G & Howes, OD 2021, 'Therapeutic potential of taar1 agonists in schizophrenia: Evidence from preclinical models and clinical studies', International Journal of Molecular Sciences, vol. 22, no. 24, 13185. https://doi.org/10.3390/ijms222413185

Osimo, EF, Sweeney, M, de Marvao, A, Berry, A, Statton, B, Perry, BI, Pillinger, T, Whitehurst, T, Cook, SA, O’Regan, DP, Thomas, EL & Howes, OD 2021, 'Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case–control study', Translational psychiatry, vol. 11, no. 1, 614. https://doi.org/10.1038/s41398-021-01741-9

Petty, A, Cui, X, Ali, A, Du, Z, Srivastav, S, Kesby, JP, Kirik, D, Howes, O & Eyles, D 2021, 'Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome', Scientific Reports, vol. 11, no. 1, 4294. https://doi.org/10.1038/s41598-021-83681-4

Pillinger, T, McCutcheon, R & Howes, O 2021, 'Variability of glucose, insulin, and lipid disturbances in first-episode psychosis: a meta-analysis', Psychological Medicine.

McCutcheon, RA, Merritt, K & Howes, OD 2021, 'Dopamine and glutamate in individuals at high risk for psychosis: a meta-analysis of in vivo imaging findings and their variability compared to controls', World Psychiatry, vol. 20, no. 3, pp. 405-416. https://doi.org/10.1002/wps.20893

Marques, TR, Veronese, M, Owen, DR, Rabiner, EA, Searle, GE & Howes, OD 2021, 'Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study', European Journal of Nuclear Medicine and Molecular Imaging, vol. 48, no. 11, pp. 3530-3539. https://doi.org/10.1007/s00259-021-05327-x

Beck, K, Arumuham, A, Veronese, M, Santangelo, B, McGinnity, CJ, Dunn, J, McCutcheon, RA, Kaar, SJ, Singh, N, Pillinger, T, Borgan, F, Stone, J, Jauhar, S, Sementa, T, Turkheimer, F, Hammers, A & Howes, OD 2021, 'N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study', Translational psychiatry, vol. 11, no. 1, 425. https://doi.org/10.1038/s41398-021-01540-2

Chesters, RA, Pepper, F, Morgan, C, Cooper, JD, Howes, OD, Vernon, AC & Stone, JM 2021, 'Brain volume in chronic ketamine users - relationship to sub-threshold psychotic symptoms and relevance to schizophrenia', Psychopharmacology. https://doi.org/10.1007/s00213-021-05873-0

Godlewska, BR, Minichino, A, Emir, U, Angelescu, I, Lennox, B, Micunovic, M, Howes, O & Cowen, PJ 2021, 'Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case-control study at 7 T', Translational psychiatry, vol. 11, no. 1, 367, pp. 367. https://doi.org/10.1038/s41398-021-01477-6

Merritt, K, McGuire, PK, Egerton, A, Aleman, A, Block, W, Bloemen, OJN, Borgan, F, Bustillo, JR, Capizzano, AA, Coughlin, JM, De La Fuente-Sandoval, C, Demjaha, A, Dempster, K, Do, KQ, Du, F, Falkai, P, Galinska-Skok, B, Gallinat, J, Gasparovic, C, Ginestet, CE, Goto, N, Graff-Guerrero, A, Ho, BC, Howes, OD, Jauhar, S, Jeon, P, Kato, T, Kaufmann, CA, Kegeles, LS, Keshavan, M, Kim, SY, Kunugi, H, Lauriello, J, Liemburg, EJ, McIlwain, ME, Modinos, G, Mouchlianitis, ED, Nakamura, J, Nenadic, I, Öngür, D, Ota, M, Palaniyappan, L, Pantelis, C, Plitman, E, Posporelis, S, Purdon, SE, Reichenbach, JR, Renshaw, PF, Russell, BR, Sawa, A, Schaefer, M, Shungu, DC, Smesny, S, Stanley, JA, Stone, JM, Szulc, A, Taylor, R, Thakkar, K, Théberge, J, Tibbo, PG, Van Amelsvoort, T, Walecki, J, Williamson, PC, Wood, SJ, Xin, L & Yamasue, H 2021, 'Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia with Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data', JAMA Psychiatry, vol. 78, no. 6, pp. 667-681. https://doi.org/10.1001/jamapsychiatry.2021.0380

Modinos, G, Richter, A, Egerton, A, Bonoldi, I, Azis, M, Antoniades, M, Bossong, M, Crossley Karmelic, N, Perez, J, Stone, J, Veronese, M, Zelaya, F, Grace, AA, Howes, O, Allen, P & McGuire, P 2021, 'Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to adverse outcomes', Neuropsychopharmacology, vol. 46, no. 8, pp. 1468-1474. https://doi.org/10.1038/s41386-021-01019-0

McQueen, G, Sendt, K-V, Gillespie, A, Avila, A, Lally, J, Vallianatou, K, Chang, N, Ferreira, D, Borgan, F, Howes, O, Barker, G, Stone, J, McGuire, P, Maccabe, J & Egerton, A 2021, 'Changes in Brain Glutamate on Switching to Clozapine in Treatment Resistant Schizophrenia', Schizophrenia Bulletin, vol. 47, no. 3, pp. 662-671. https://doi.org/10.1093/schbul/sbaa156

Howes, OD & Mehta, MA 2021, 'Challenges in CNS drug development and the role of imaging', Psychopharmacology, vol. 238, no. 5, pp. 1229-1230. https://doi.org/10.1007/s00213-021-05838-3

D'Ambrosio, E, Jauhar, S, Kim, S, Veronese, M, Rogdaki, M, Pepper, F, Bonoldi, I, Kotoula, V, Kempton, MJ, Turkheimer, F, Kwon, JS, Kim, E & Howes, OD 2021, 'The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal 18F-DOPA PET and voxel-based morphometry study', Molecular Psychiatry, vol. 26, no. 4, pp. 1332–1345. https://doi.org/10.1038/s41380-019-0570-6

Gifford, G, Crossley, N, Morgan, S, Kempton, MJ, Dazzan, P, Modinos, G, Azis, M, Samson, C, Bonoldi, I, Quinn, B, Smart, SE, Antoniades, M, Bossong, MG, Broome, MR, Perez, J, Howes, OD, Stone, JM, Allen, P, Grace, AA & McGuire, P 2021, 'Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis', Human Brain Mapping, vol. 42, no. 2, pp. 439-451. https://doi.org/10.1002/hbm.25235

Marques, TR, Natesan, S, Rabiner, EA, Searle, GE, Gunn, R, Howes, OD & Kapur, S 2021, 'Adenosine A_2A receptor in schizophrenia: an in vivo brain PET imaging study', Psychopharmacology. https://doi.org/10.1007/s00213-021-05900-0

Chen, KC, Yang, YK, Howes, OD, Lee, IH, Yeh, TL, Chiu, NT, Chen, PS, David, AS & Bramon, E 2021, 'Striatal dopamine D_2/3receptors in medication-naïve schizophrenia: An [¹²³I] IBZM SPECT study', Psychological Medicine. https://doi.org/10.1017/S0033291720005413

Eap, CB, Gründer, G, Baumann, P, Ansermot, N, Conca, A, Corruble, E, Crettol, S, Dahl, ML, de Leon, J, Greiner, C, Howes, O, Kim, E, Lanzenberger, R, Meyer, JH, Moessner, R, Mulder, H, Müller, DJ, Reis, M, Riederer, P, Ruhe, HG, Spigset, O, Spina, E, Stegman, B, Steimer, W, Stingl, J, Suzen, S, Uchida, H, Unterecker, S, Vandenberghe, F & Hiemke, C 2021, 'Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants', World Journal of Biological Psychiatry, vol. 22, no. 8, pp. 561-628. https://doi.org/10.1080/15622975.2021.1878427

Potkin, SG, Kane, JM, Correll, CU, Lindenmayer, JP, Agid, O, Marder, SR, Olfson, M & Howes, OD 2020, 'The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research', NPJ SCHIZOPHRENIA, vol. 6, no. 1, 1. https://doi.org/10.1038/s41537-019-0090-z

McCutcheon, RA, Jauhar, S, Pepper, F, Nour, MM, Rogdaki, M, Veronese, M, Turkheimer, FE, Egerton, A, McGuire, P, Mehta, MM & Howes, OD 2020, 'The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 5, no. 11, pp. 1040-1051. https://doi.org/10.1016/j.bpsc.2020.04.004

Howes, O, Whitehurst, T, Shatalina, E, Townsend, L, Onwordi, EC, Allenis Mak, TL, Arumuham, A, O'brien, O, Vano, L, Lobo, M, Zahid, U, Butler, E & Osugo, M 2020, 'The clinical significance of duration of untreated psychosis: an umbrella review and random-effects meta-analysis', World Psychiatry.

Wright, P, Veronese, M, Mazibuko, N, Turkheimer, FE, Rabiner, EA, Ballard, CG, Williams, SCR, Hari Narayanan, AK, Osrah, B, Williams, R, Marques, TR, Howes, OD, Roncaroli, F & O'Sullivan, MJ 2020, 'Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison', Frontiers in Neurology, vol. 11, 541377, pp. 541377. https://doi.org/10.3389/fneur.2020.541377, https://doi.org/10.3389/fneur.2020.541377

Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Emily, L, Lawrie, S, Lees, J, Lewis, SW, Lythgoe, D, Matthews, JC, McGuire, P, Lily, M, Semple, S, Shaw, A, Singh, K, Stockton-Powdrell, C, Talbot, PS, Veronese, M, Wagner, E, Walters, J, Williams, S, Maccabe, J & Howes, O 2020, 'Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis: A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA).', Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbaa128

Lawn, W, Hill, J, Hindocha, C, Yim, J, Yamamori, Y, Jones, G, Walker, H, Green, SF, Wall, MB, Howes, OD, Curran, HV, Freeman, TP & Bloomfield, MAP 2020, 'The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers', Journal of Psychopharmacology, vol. 34, no. 9, pp. 969-980. https://doi.org/10.1177/0269881120944148

Rogdaki, M, Gudbrandsen, M, McCutcheon, RA, Blackmore, CE, Brugger, S, Ecker, C, Craig, MC, Daly, E, Murphy, DGM & Howes, O 2020, 'Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis', Molecular Psychiatry, vol. 25, no. 8, pp. 1704–1717. https://doi.org/10.1038/s41380-019-0638-3

Osimo, EF, Pillinger, T, Rodriguez, IM, Khandaker, GM, Pariante, CM & Howes, OD 2020, 'Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls', Brain, Behavior, and Immunity, vol. 87, pp. 901-909. https://doi.org/10.1016/j.bbi.2020.02.010